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Income Taxes - Income Tax Provision Related to Continuing Operations (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
U.S. federal provision (benefit)
At statutory rate	$ (33,627)	$ (53,427)	$ (28,235)
Tax law changes	248,155	0	0
Non-cash interest expense on liability related to sale of future royalties	6,604	6,899	7,217
Non-deductible officers' compensation	2,547	220	184
Change in valuation allowance	(186,124)	51,981	22,210
Stock-based compensation	(20,665)	528	674
Sale of future royalties	(8,236)	0	0
Research credits	(8,038)	(4,543)	(4,529)
Foreign tax deduction	0	0	1,773
Other	0	(782)	1,212
Provision for income taxes	$ 616	$ 876	$ 506

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Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.

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