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Selected Quarterly Financial Data - Quarterly Financial Data (Detail) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2017	Sep. 30, 2017	Jun. 30, 2017	Mar. 31, 2017	Dec. 31, 2016	Sep. 30, 2016	Jun. 30, 2016	Mar. 31, 2016	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Income Statement [Abstract]
Product sales	$ 7,791	$ 4,448	$ 15,693	$ 4,756	$ 13,690	$ 14,698	$ 12,867	$ 14,099	$ 32,688	$ 55,354	$ 40,155
Total revenue	95,466	152,928	34,589	24,728	37,450	36,336	32,768	58,882	307,711	165,436	230,784
Cost of goods sold	9,753	5,674	8,989	6,131	6,604	7,033	7,708	8,870	30,547	30,215	34,102
Research and development expenses	81,429	65,714	60,260	61,058	50,232	51,951	52,350	49,268	268,461	203,801	182,787
Operating income (loss)	(24,034)	69,485	(50,656)	(54,437)	(32,145)	(32,901)	(38,325)	(9,484)	(59,642)	(112,855)	(29,371)
Net income (loss)	$ (33,826)	$ 60,871	$ (59,871)	$ (63,866)	$ (42,199)	$ (43,224)	$ (48,603)	$ (19,498)	$ (96,692)	$ (153,524)	$ (81,177)
Net income (loss) per share
Basic	$ (0.21)	$ 0.39	$ (0.39)	$ (0.42)	$ (0.28)	$ (0.32)	$ (0.36)	$ (0.14)
Diluted	$ (0.21)	$ 0.37	$ (0.39)	$ (0.42)	$ (0.28)	$ (0.32)	$ (0.36)	$ (0.14)

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Total costs related to goods produced and sold during the reporting period.

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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