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Organization and Summary of Significant Accounting Policies - Impact of Adoption of ASC 606 on Condensed Consolidated Balance Sheet and Condensed Consolidated Statement of Operations (Detail) - USD ($) $ in Thousands | 3 Months Ended |
--- | --- | ---
Mar. 31, 2018 | Mar. 31, 2017 | Dec. 31, 2017
Condensed Consolidated Balance Sheet data |  |  |
Accounts receivable, net | $ 15,607 |  | $ 5,014
Deferred revenue, current portion | 19,531 |  | 18,949
Deferred revenue, less current portion | 12,808 |  | 19,021
Accumulated deficit | (2,201,156) |  | $ (2,117,941)
Condensed Consolidated Statement of Operations data |  |  |
Royalty revenue | 11,076 | $ 7,217 |
License, collaboration and other revenue | 13,727 | 6,092 |
Total revenue | 38,018 | $ 24,728 |
ASC 606 [Member] | Adjustments [Member] |  |  |
Condensed Consolidated Balance Sheet data |  |  |
Accounts receivable, net | (11,077) |  |
Deferred revenue, current portion | 600 |  |
Deferred revenue, less current portion | 1,140 |  |
Accumulated deficit | (12,817) |  |
Condensed Consolidated Statement of Operations data |  |  |
Royalty revenue | (332) |  |
License, collaboration and other revenue | 213 |  |
Total revenue | (119) |  |
ASC 606 [Member] | Calculated under Revenue Guidance in Effect before Topic 606 [Member] |  |  |
Condensed Consolidated Balance Sheet data |  |  |
Accounts receivable, net | 4,530 |  |
Deferred revenue, current portion | 20,131 |  |
Deferred revenue, less current portion | 13,948 |  |
Accumulated deficit | (2,213,973) |  |
Condensed Consolidated Statement of Operations data |  |  |
Royalty revenue | 10,744 |  |
License, collaboration and other revenue | 13,940 |  |
Total revenue | $ 37,899 |  |

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