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v3.8.0.1

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2018 | Mar. 31, 2017
Cash flows from operating activities: |  |
Net loss | $ (95,792) | $ (63,866)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Non-cash royalty revenue related to sale of future royalties | (6,920) | (6,663)
Non-cash interest expense on liability related to sale of future royalties | 5,019 | 4,552
Stock-based compensation | 19,949 | 8,184
Depreciation and amortization | 2,541 | 4,033
Other non-cash transactions | (370) | (731)
Changes in operating assets and liabilities: |  |
Accounts receivable, net | 151 | 14,113
Inventory | 51 | (1,907)
Other assets | 1,853 | 2,134
Accounts payable | 6,492 | 4,117
Accrued compensation | 6,867 | (6,817)
Accrued clinical trial expenses | 10,329 | (515)
Other accrued expenses | 605 | 1,798
Interest payable | (108) | (108)
Deferred revenue | (3,678) | 9,619
Other liabilities | 545 | (2,509)
Net cash used in operating activities | (52,466) | (34,566)
Cash flows from investing activities: |  |
Purchases of investments | 0 | (75,857)
Maturities of investments | 37,232 | 58,053
Sales of investments | 11,963 | 8,823
Purchases of property, plant and equipment | (985) | (4,089)
Net cash provided by (used in) investing activities | 48,210 | (13,070)
Cash flows from financing activities: |  |
Payment of capital lease obligations | 0 | (613)
Proceeds from shares issued under equity compensation plans | 34,352 | 11,792
Net cash provided by financing activities | 34,352 | 11,179
Effect of exchange rates on cash and cash equivalents | (53) | 297
Net increase (decrease) in cash and cash equivalents | 30,043 | (36,160)
Cash and cash equivalents at beginning of period | 4,762 | 59,640
Cash and cash equivalents at end of period | 34,805 | 23,480
Supplemental disclosure of cash flow information: |  |
Cash paid for interest | $ 4,952 | $ 5,067

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