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Organization and Summary of Significant Accounting Policies - Impact of Adoption of ASC 606 on Condensed Consolidated Balance Sheet and Condensed Consolidated Statement of Operations (Detail) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017	Dec. 31, 2017
Condensed Consolidated Balance Sheet data
Accounts receivable, net	$ 15,607		$ 5,014
Deferred revenue, current portion	19,531		18,949
Deferred revenue, less current portion	12,808		19,021
Accumulated deficit	(2,201,156)		$ (2,117,941)
Condensed Consolidated Statement of Operations data
Royalty revenue	11,076	$ 7,217
License, collaboration and other revenue	13,727	6,092
Total revenue	38,018	$ 24,728
ASC 606 [Member] | Adjustments [Member]
Condensed Consolidated Balance Sheet data
Accounts receivable, net	(11,077)
Deferred revenue, current portion	600
Deferred revenue, less current portion	1,140
Accumulated deficit	(12,817)
Condensed Consolidated Statement of Operations data
Royalty revenue	(332)
License, collaboration and other revenue	213
Total revenue	(119)
ASC 606 [Member] | Calculated under Revenue Guidance in Effect before Topic 606 [Member]
Condensed Consolidated Balance Sheet data
Accounts receivable, net	4,530
Deferred revenue, current portion	20,131
Deferred revenue, less current portion	13,948
Accumulated deficit	(2,213,973)
Condensed Consolidated Statement of Operations data
Royalty revenue	10,744
License, collaboration and other revenue	13,940
Total revenue	$ 37,899

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