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License and Collaboration Agreements - License, Collaboration and Other Revenue (Detail) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
License And Collaboration Agreements [Line Items]    
License, collaboration and other revenue $ 13,727 $ 6,092
Baxalta Incorporated/Shire [Member] | ADYNOVATE [Member]    
License And Collaboration Agreements [Line Items]    
License, collaboration and other revenue 10,011 0
Eli Lilly and Company [Member] | NKTR-358 [Member]    
License And Collaboration Agreements [Line Items]    
License, collaboration and other revenue 2,354 0
Amgen, Inc. [Member] | Neulasta [Member]    
License And Collaboration Agreements [Line Items]    
License, collaboration and other revenue 1,250 1,250
AstraZeneca AB [Member] | MOVANTIK and MOVANTIK fixed-dose combination program [Member]    
License And Collaboration Agreements [Line Items]    
License, collaboration and other revenue 0 3,000
Other [Member]    
License And Collaboration Agreements [Line Items]    
License, collaboration and other revenue $ 112 $ 1,842