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Organization and Summary of Significant Accounting Policies - Impact of Adoption of ASC 606 on Condensed Consolidated Balance Sheet and Condensed Consolidated Statement of Operations (Detail) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended |
--- | --- | --- | ---
Jun. 30, 2018 | Jun. 30, 2017 | Jun. 30, 2018 | Jun. 30, 2017 | Dec. 31, 2017
Condensed Consolidated Balance Sheet data |  |  |  |  |
Accounts receivable, net | $ 35,315 |  | $ 35,315 |  | $ 5,014
Deferred revenue, current portion | 17,988 |  | 17,988 |  | 18,949
Deferred revenue, less current portion | 13,780 |  | 13,780 |  | 19,021
Accumulated deficit | (1,229,696) |  | (1,229,696) |  | $ (2,117,941)
Condensed Consolidated Statement of Operations data |  |  |  |  |
Total revenue | 1,087,717 | $ 34,589 | 1,125,735 | $ 59,317 |
Royalty [Member] |  |  |  |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |
Total revenue | 8,563 | 7,434 | 19,639 | 14,651 |
License, Collaboration and Other Revenue [Member] |  |  |  |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |
Total revenue | 1,064,246 | 4,824 | 1,077,973 | 10,916 |
Product Sales [Member] |  |  |  |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |
Total revenue | 5,863 | $ 15,693 | 12,158 | $ 20,449 |
ASC 606 [Member] | Adjustments [Member] |  |  |  |  |
Condensed Consolidated Balance Sheet data |  |  |  |  |
Accounts receivable, net | (9,875) |  | (9,875) |  |
Deferred revenue, current portion | 650 |  | 650 |  |
Deferred revenue, less current portion | 978 |  | 978 |  |
Accumulated deficit | (11,503) |  | (11,503) |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |
Total revenue | 1,314 |  | 1,195 |  |
ASC 606 [Member] | Adjustments [Member] | Royalty [Member] |  |  |  |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |
Total revenue | 1,201 |  | 869 |  |
ASC 606 [Member] | Adjustments [Member] | License, Collaboration and Other Revenue [Member] |  |  |  |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |
Total revenue | 305 |  | 518 |  |
ASC 606 [Member] | Adjustments [Member] | Product Sales [Member] |  |  |  |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |
Total revenue | (192) |  | (192) |  |
ASC 606 [Member] | Calculated under Revenue Guidance in Effect before Topic 606 [Member] |  |  |  |  |
Condensed Consolidated Balance Sheet data |  |  |  |  |
Accounts receivable, net | 25,440 |  | 25,440 |  |
Deferred revenue, current portion | 18,638 |  | 18,638 |  |
Deferred revenue, less current portion | 14,758 |  | 14,758 |  |
Accumulated deficit | (1,241,199) |  | (1,241,199) |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |
Total revenue | 1,089,031 |  | 1,126,930 |  |
ASC 606 [Member] | Calculated under Revenue Guidance in Effect before Topic 606 [Member] | Royalty [Member] |  |  |  |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |
Total revenue | 9,764 |  | 20,508 |  |
ASC 606 [Member] | Calculated under Revenue Guidance in Effect before Topic 606 [Member] | License, Collaboration and Other Revenue [Member] |  |  |  |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |
Total revenue | 1,064,551 |  | 1,078,491 |  |
ASC 606 [Member] | Calculated under Revenue Guidance in Effect before Topic 606 [Member] | Product Sales [Member] |  |  |  |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |
Total revenue | $ 5,671 |  | $ 11,966 |  |

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