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v3.10.0.1

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) | 6 Months Ended
--- | ---
Jun. 30, 2018 | Jun. 30, 2017
Cash flows from operating activities: |  |
Net income (loss) | $ 875,668,000 | $ (123,737,000)
Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities: |  |
Non-cash royalty revenue related to sale of future royalties | (15,965,000) | (13,301,000)
Non-cash interest expense on liability related to sale of future royalties | 9,994,000 | 9,064,000
Stock-based compensation | 40,608,000 | 16,283,000
Depreciation and amortization | 5,115,000 | 8,287,000
Other non-cash transactions | (3,991,000) | (1,089,000)
Changes in operating assets and liabilities: |  |
Accounts receivable, net | (19,557,000) | 11,564,000
Inventory | (1,158,000) | 101,000
Other assets | (14,282,000) | 2,280,000
Accounts payable | 5,791,000 | 3,221,000
Accrued compensation | 10,717,000 | (3,934,000)
Accrued clinical trial expenses | 10,567,000 | (1,275,000)
Other accrued expenses | 4,904,000 | 2,388,000
Interest payable | (54,000) | (54,000)
Deferred revenue | (6,249,000) | (3,887,000)
Other liabilities | 5,068,000 | 1,000,000
Net cash provided by (used in) operating activities | 907,176,000 | (93,089,000)
Cash flows from investing activities: |  |
Purchases of investments | (989,850,000) | (121,135,000)
Maturities of investments | 132,779,000 | 147,558,000
Sales of investments | 11,963,000 | 8,823,000
Purchases of property, plant and equipment | (3,730,000) | (6,344,000)
Sales of property, plant and equipment | 2,633,000 | 0
Net cash (used in) provided by investing activities | (846,205,000) | 28,902,000
Cash flows from financing activities: |  |
Payment of capital lease obligations | 0 | (1,369,000)
Issuance of common stock | 790,231,000 | 0
Proceeds from shares issued under equity compensation plans | 55,208,000 | 22,016,000
Net cash provided by financing activities | 845,439,000 | 20,647,000
Effect of exchange rates on cash and cash equivalents | (47,000) | 49,000
Net increase (decrease) in cash and cash equivalents | 906,363,000 | (43,491,000)
Cash and cash equivalents at beginning of period | 4,762,000 | 59,640,000
Cash and cash equivalents at end of period | 911,125,000 | 16,149,000
Supplemental disclosure of cash flow information: |  |
Cash paid for interest | $ 9,795,000 | $ 10,010,000

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