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Organization and Summary of Significant Accounting Policies - Impact of Adoption of ASC 606 on Condensed Consolidated Balance Sheet and Condensed Consolidated Statement of Operations (Detail) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended |
--- | --- | --- | ---
Sep. 30, 2018 | Sep. 30, 2017 | Sep. 30, 2018 | Sep. 30, 2017 | Dec. 31, 2017
Condensed Consolidated Balance Sheet data |  |  |  |  |
Accounts receivable, net | $ 31,937 |  | $ 31,937 |  | $ 5,014
Deferred revenue, current portion | 15,676 |  | 15,676 |  | 18,949
Deferred revenue, less current portion | 11,410 |  | 11,410 |  | 19,021
Accumulated deficit | (1,325,839) |  | (1,325,839) |  | $ (2,117,941)
Condensed Consolidated Statement of Operations data |  |  |  |  |
Total revenue | 27,762 | $ 152,928 | 1,153,497 | $ 212,245 |
Royalty [Member] |  |  |  |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |
Total revenue | 10,259 | 9,302 | 29,898 | 23,953 |
License, Collaboration and Other Revenue [Member] |  |  |  |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |
Total revenue | 4,875 | 131,112 | 1,082,848 | 142,028 |
Product Sales [Member] |  |  |  |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |
Total revenue | 4,256 | $ 4,448 | 16,414 | $ 24,897 |
ASC 606 [Member] | Adjustments [Member] |  |  |  |  |
Condensed Consolidated Balance Sheet data |  |  |  |  |
Accounts receivable, net | (10,549) |  | (10,549) |  |
Deferred revenue, current portion | 1,191 |  | 1,191 |  |
Deferred revenue, less current portion | 187 |  | 187 |  |
Accumulated deficit | (11,927) |  | (11,927) |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |
Total revenue | (375) |  | 770 |  |
ASC 606 [Member] | Adjustments [Member] | Royalty [Member] |  |  |  |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |
Total revenue | (674) |  | 195 |  |
ASC 606 [Member] | Adjustments [Member] | License, Collaboration and Other Revenue [Member] |  |  |  |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |
Total revenue | 299 |  | 767 |  |
ASC 606 [Member] | Adjustments [Member] | Product Sales [Member] |  |  |  |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |
Total revenue | 0 |  | (192) |  |
ASC 606 [Member] | Calculated under Revenue Guidance in Effect before Topic 606 [Member] |  |  |  |  |
Condensed Consolidated Balance Sheet data |  |  |  |  |
Accounts receivable, net | 21,388 |  | 21,388 |  |
Deferred revenue, current portion | 16,867 |  | 16,867 |  |
Deferred revenue, less current portion | 11,597 |  | 11,597 |  |
Accumulated deficit | (1,337,766) |  | (1,337,766) |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |
Total revenue | 27,387 |  | 1,154,267 |  |
ASC 606 [Member] | Calculated under Revenue Guidance in Effect before Topic 606 [Member] | Royalty [Member] |  |  |  |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |
Total revenue | 9,585 |  | 30,093 |  |
ASC 606 [Member] | Calculated under Revenue Guidance in Effect before Topic 606 [Member] | License, Collaboration and Other Revenue [Member] |  |  |  |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |
Total revenue | 5,174 |  | 1,083,615 |  |
ASC 606 [Member] | Calculated under Revenue Guidance in Effect before Topic 606 [Member] | Product Sales [Member] |  |  |  |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |
Total revenue | $ 4,256 |  | $ 16,222 |  |

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