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v3.10.0.1

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) | 9 Months Ended
--- | ---
Sep. 30, 2018 | Sep. 30, 2017
Cash flows from operating activities: |  |
Net income (loss) | $ 779,525,000 | $ (62,866,000)
Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities: |  |
Non-cash royalty revenue related to sale of future royalties | (24,337,000) | (21,367,000)
Non-cash interest expense on liability related to sale of future royalties | 14,808,000 | 13,535,000
Stock-based compensation | 63,895,000 | 25,118,000
Depreciation and amortization | 7,799,000 | 12,081,000
Other non-cash transactions | (8,136,000) | (1,370,000)
Changes in operating assets and liabilities: |  |
Accounts receivable, net | (16,179,000) | 12,364,000
Inventory | (2,570,000) | (2,545,000)
Other assets | (22,087,000) | (2,036,000)
Accounts payable | 2,611,000 | 5,729,000
Accrued compensation | 19,659,000 | 808,000
Accrued clinical trial expenses | 12,505,000 | (958,000)
Other accrued expenses | 14,098,000 | 4,971,000
Deferred revenue | (10,931,000) | 15,477,000
Other liabilities | 5,104,000 | 1,046,000
Net cash provided by (used in) operating activities | 835,764,000 | (13,000)
Cash flows from investing activities: |  |
Purchases of investments | (1,944,178,000) | (314,439,000)
Maturities of investments | 467,658,000 | 261,112,000
Sales of investments | 11,963,000 | 8,823,000
Purchases of property, plant and equipment | (5,552,000) | (7,283,000)
Sales of property, plant and equipment | 2,633,000 | 0
Net cash used in investing activities | (1,467,476,000) | (51,787,000)
Cash flows from financing activities: |  |
Payment of capital lease obligations | 0 | (2,159,000)
Issuance of common stock | 790,231,000 | 0
Proceeds from shares issued under equity compensation plans | 59,067,000 | 32,275,000
Net cash provided by financing activities | 849,298,000 | 30,116,000
Effect of exchange rates on cash and cash equivalents | (87,000) | 11,000
Net increase (decrease) in cash and cash equivalents | 217,499,000 | (21,673,000)
Cash and cash equivalents at beginning of period | 4,762,000 | 59,640,000
Cash and cash equivalents at end of period | 222,261,000 | 37,967,000
Supplemental disclosure of cash flow information: |  |
Cash paid for interest | $ 14,701,000 | $ 14,989,000

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