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License and Collaboration Agreements - Changes in Deferred Revenue Balance from Collaboration Agreements (Detail) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2018	Jan. 01, 2018
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Deferred revenue, Beginning balance	$ 37,970
Additions to deferred revenue	4,000
Recognition of previously unearned revenue	(12,931)
Deferred revenue, Ending balance	$ 27,086
ASC 606 [Member]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Transition adjustment related to adoption of ASC 606		$ (1,953)

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Amount of obligation to transfer good or service to customer for which consideration has been received or is receivable.

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