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Organization and Summary of Significant Accounting Policies - Additional Information (Detail) $ in Thousands, shares in Millions |  | 3 Months Ended | 12 Months Ended
--- | --- | --- | ---
Jan. 01, 2018 USD ($) | Dec. 31, 2018 USD ($) Customer | Sep. 30, 2018 USD ($) | Jun. 30, 2018 USD ($) | Mar. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) Customer | Sep. 30, 2017 USD ($) | Jun. 30, 2017 USD ($) | Mar. 31, 2017 USD ($) | Dec. 31, 2018 USD ($) Customer Reporting_Unit shares | Dec. 31, 2017 USD ($) Customer shares | Dec. 31, 2016 USD ($) shares
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Cash and investments in marketable securities |  | $ 1,918,239 |  |  |  | $ 353,220 |  |  |  | $ 1,918,239 | $ 353,220 |
Senior secured notes |  | $ 250,000 |  |  |  |  |  |  |  | $ 250,000 |  |
Senior secured notes, maturity date |  |  |  |  |  |  |  |  |  | Oct. 05, 2020 |  |
Contract with customer, asset, reclassified to receivable |  |  |  |  |  |  |  |  |  | $ 24,200 | 3,300 |
Net expense reimbursements from collaboration partner |  |  |  |  |  |  |  |  |  | $ 19,000 | $ 1,700 |
Number of customers accounted for major accounts receivable | Customer |  | 3 |  |  |  | 4 |  |  |  | 3 | 4 |
Percentage of accounts receivable customers one |  |  |  |  |  |  |  |  |  | 44.00% | 43.00% |
Percentage of accounts receivable customers two |  |  |  |  |  |  |  |  |  | 36.00% | 20.00% |
Percentage of accounts receivable customers three |  |  |  |  |  |  |  |  |  | 12.00% | 19.00% |
Percentage of accounts receivable customers four |  |  |  |  |  |  |  |  |  |  | 14.00% |
Number of reporting unit evaluated for goodwill | Reporting_Unit |  |  |  |  |  |  |  |  |  | 1 |  |
Customer payment period from receipt of invoice |  |  |  |  |  |  |  |  |  | 30 days |  |
Weighted-average of potentially dilutive securities (stock options and RSUs) included in calculation of diluted securities under treasury stock method | shares |  |  |  |  |  |  |  |  |  | 10.5 |  |
Minimum percentage of amount realized upon ultimate settlement |  |  |  |  |  |  |  |  |  | 50.00% |  |
Revenue recognized from contracts with customers |  | $ 39,826 | $ 27,762 | $ 1,087,717 | $ 38,018 | $ 95,466 | $ 152,928 | $ 34,589 | $ 24,728 | $ 1,193,323 | $ 307,711 | $ 165,436
Deferred rent |  | 9,300 |  |  |  | 6,000 |  |  |  | 9,300 | 6,000 |
Royalty [Member] |  |  |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Revenue recognized from contracts with customers |  |  |  |  |  |  |  |  |  | 41,976 | $ 33,527 | $ 19,542
ASC 606 [Member] |  |  |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Adjustment to retained earnings | $ 12,700 |  |  |  |  |  |  |  |  |  |  |
Reduction of deferred revenue | (2,000) |  |  |  |  |  |  |  |  |  |  |
ASC 606 [Member] | MOVANTIK and ADYNOVATE [Member] |  |  |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Revenue recognized from contracts with customers |  |  |  |  | $ 11,100 | $ 9,600 |  |  |  |  |  |
Type of Revenue [Extensible List] |  |  |  |  | us-gaap:RoyaltyMember | us-gaap:RoyaltyMember |  |  |  |  |  |
ASC 606 [Member] | Calculated under Revenue Guidance in Effect before Topic 606 [Member] |  |  |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Revenue recognized from contracts with customers |  |  |  |  |  |  |  |  |  | 1,183,911 |  |
ASC 606 [Member] | Royalty [Member] | Calculated under Revenue Guidance in Effect before Topic 606 [Member] |  |  |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Adjustment to retained earnings | 10,700 |  |  |  |  |  |  |  |  |  |  |
Revenue recognized from contracts with customers |  |  |  |  |  |  |  |  |  | $ 41,690 |  |
ASC 606 [Member] | Royalty [Member] | Calculated under Revenue Guidance in Effect before Topic 606 [Member] | MOVANTIK and ADYNOVATE [Member] |  |  |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Adjustment to retained earnings | $ 10,700 |  |  |  |  |  |  |  |  |  |  |
Stock Options and Restricted Stock Units [Member] |  |  |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Weighted average antidilutive securities excluded from computation of earnings per share | shares |  |  |  |  |  |  |  |  |  |  | 20.6 | 19.9
Shares of Common Stock Underlying Outstanding Stock Options [Member] |  |  |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Weighted average antidilutive securities excluded from computation of earnings per share | shares |  |  |  |  |  |  |  |  |  | 3.3 |  |
Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Operating Lease, Right-of-Use Asset |  | 87,000 |  |  |  |  |  |  |  | $ 87,000 |  |
Operating Lease, Liability |  | 96,000 |  |  |  |  |  |  |  | 96,000 |  |
Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Operating Lease, Right-of-Use Asset |  | 97,000 |  |  |  |  |  |  |  | 97,000 |  |
Operating Lease, Liability |  | $ 106,000 |  |  |  |  |  |  |  | $ 106,000 |  |
Buildings [Member] |  |  |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Property and equipment estimated useful lives |  |  |  |  |  |  |  |  |  | 20 years |  |
Manufacturing Laboratory and Other Equipment [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Property and equipment estimated useful lives |  |  |  |  |  |  |  |  |  | 3 years |  |
Manufacturing Laboratory and Other Equipment [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Property and equipment estimated useful lives |  |  |  |  |  |  |  |  |  | 10 years |  |

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