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Income Taxes - Significant Components of Deferred Tax Assets and Liabilities (Detail) - USD ($) $ in Thousands | Dec. 31, 2018 | Dec. 31, 2017
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 300,693 | $ 364,864
Research and other credits | 116,955 | 94,103
Stock-based compensation | 21,518 | 14,552
Capitalized research expenses | 8,072 | 5,497
Reserves and accruals | 8,066 | 5,659
Deferred revenue | 4,467 | 3,796
Property, plant and equipment | 2,124 | 6,848
Other | (1,270) | 1,156
Deferred tax assets before valuation allowance | 460,625 | 496,475
Valuation allowance for deferred tax assets | (460,455) | (496,191)
Total deferred tax assets | 170 | 284
Total deferred tax liabilities | 0 | 0
Net deferred tax assets | $ 170 | $ 284

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