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Organization and Summary of Significant Accounting Policies - Impact of Adoption of ASC 606 on Condensed Consolidated Balance Sheet and Condensed Consolidated Statement of Operations (Detail) - USD ($) $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2018 | Sep. 30, 2018 | Jun. 30, 2018 | Mar. 31, 2018 | Dec. 31, 2017 | Sep. 30, 2017 | Jun. 30, 2017 | Mar. 31, 2017 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Condensed Consolidated Balance Sheet data |  |  |  |  |  |  |  |  |  |  |
Accounts receivable, net | $ 43,213 |  |  |  | $ 5,014 |  |  |  | $ 43,213 | $ 5,014 |
Deferred revenue, current portion | 13,892 |  |  |  | 18,949 |  |  |  | 13,892 | 18,949 |
Deferred revenue, less current portion | 10,744 |  |  |  | 19,021 |  |  |  | 10,744 | 19,021 |
Accumulated deficit | (1,424,051) |  |  |  | (2,117,941) |  |  |  | (1,424,051) | (2,117,941) |
Condensed Consolidated Statement of Operations data |  |  |  |  |  |  |  |  |  |  |
Total revenue | 39,826 | $ 27,762 | $ 1,087,717 | $ 38,018 | 95,466 | $ 152,928 | $ 34,589 | $ 24,728 | 1,193,323 | 307,711 | $ 165,436
Product Sales [Member] |  |  |  |  |  |  |  |  |  |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |  |  |  |  |  |  |
Total revenue | 4,360 | $ 4,256 | $ 5,863 | $ 6,295 | $ 7,791 | $ 4,448 | $ 15,693 | $ 4,756 | 20,774 | 32,688 | 55,354
Royalty [Member] |  |  |  |  |  |  |  |  |  |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |  |  |  |  |  |  |
Total revenue |  |  |  |  |  |  |  |  | 41,976 | 33,527 | 19,542
License, Collaboration and Other Revenue [Member] |  |  |  |  |  |  |  |  |  |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |  |  |  |  |  |  |
Total revenue |  |  |  |  |  |  |  |  | 1,097,265 | $ 210,965 | $ 60,382
ASC 606 [Member] | Adjustments [Member] |  |  |  |  |  |  |  |  |  |  |
Condensed Consolidated Balance Sheet data |  |  |  |  |  |  |  |  |  |  |
Accounts receivable, net | (21,030) |  |  |  |  |  |  |  | (21,030) |  |
Deferred revenue, current portion | 1,191 |  |  |  |  |  |  |  | 1,191 |  |
Deferred revenue, less current portion | (112) |  |  |  |  |  |  |  | (112) |  |
Accumulated deficit | (22,109) |  |  |  |  |  |  |  | (22,109) |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |  |  |  |  |  |  |
Total revenue |  |  |  |  |  |  |  |  | (9,412) |  |
ASC 606 [Member] | Adjustments [Member] | Product Sales [Member] |  |  |  |  |  |  |  |  |  |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |  |  |  |  |  |  |
Total revenue |  |  |  |  |  |  |  |  | (192) |  |
ASC 606 [Member] | Adjustments [Member] | Royalty [Member] |  |  |  |  |  |  |  |  |  |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |  |  |  |  |  |  |
Total revenue |  |  |  |  |  |  |  |  | (286) |  |
ASC 606 [Member] | Adjustments [Member] | License, Collaboration and Other Revenue [Member] |  |  |  |  |  |  |  |  |  |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |  |  |  |  |  |  |
Total revenue |  |  |  |  |  |  |  |  | (8,934) |  |
ASC 606 [Member] | Calculated under Revenue Guidance in Effect before Topic 606 [Member] |  |  |  |  |  |  |  |  |  |  |
Condensed Consolidated Balance Sheet data |  |  |  |  |  |  |  |  |  |  |
Accounts receivable, net | 22,183 |  |  |  |  |  |  |  | 22,183 |  |
Deferred revenue, current portion | 15,083 |  |  |  |  |  |  |  | 15,083 |  |
Deferred revenue, less current portion | 10,632 |  |  |  |  |  |  |  | 10,632 |  |
Accumulated deficit | $ (1,446,160) |  |  |  |  |  |  |  | (1,446,160) |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |  |  |  |  |  |  |
Total revenue |  |  |  |  |  |  |  |  | 1,183,911 |  |
ASC 606 [Member] | Calculated under Revenue Guidance in Effect before Topic 606 [Member] | Product Sales [Member] |  |  |  |  |  |  |  |  |  |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |  |  |  |  |  |  |
Total revenue |  |  |  |  |  |  |  |  | 20,582 |  |
ASC 606 [Member] | Calculated under Revenue Guidance in Effect before Topic 606 [Member] | Royalty [Member] |  |  |  |  |  |  |  |  |  |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |  |  |  |  |  |  |
Total revenue |  |  |  |  |  |  |  |  | 41,690 |  |
ASC 606 [Member] | Calculated under Revenue Guidance in Effect before Topic 606 [Member] | License, Collaboration and Other Revenue [Member] |  |  |  |  |  |  |  |  |  |  |
Condensed Consolidated Statement of Operations data |  |  |  |  |  |  |  |  |  |  |
Total revenue |  |  |  |  |  |  |  |  | $ 1,088,331 |  |

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