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License and Collaboration Agreements - Changes in Deferred Revenue Balance from Collaboration Agreements (Detail) - USD ($) $ in Thousands | 12 Months Ended |
--- | --- | ---
Dec. 31, 2018 | Jan. 01, 2018
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |
Deferred revenue, Beginning balance | $ 37,970 |
Additions to deferred revenue | 5,950 |
Recognition of previously unearned revenue | (17,331) |
Deferred revenue, Ending balance | $ 24,636 |
ASC 606 [Member] |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |
Transition adjustment related to adoption of ASC 606 |  | $ (1,953)

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