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Organization and Summary of Significant Accounting Policies - Additional Information (Detail) |  | 3 Months Ended |
--- | --- | --- | ---
Jan. 01, 2019 USD ($) | Mar. 31, 2019 USD ($) Segment | Mar. 31, 2018 USD ($) | Dec. 31, 2018 USD ($)
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Cash and investments in marketable securities |  | $ 1,844,532,000 |  | $ 1,918,239,000
Senior secured notes |  | $ 250,000,000 |  |
Senior secured notes, maturity date |  | Oct. 05, 2020 |  |
Number of business segment | Segment |  | 1 |  |
Accounts receivable from contracts with customers |  | $ 14,500,000 |  | 24,200,000
Accounts receivable for expense reimbursements from collaboration partner |  | 42,894,000 |  | 43,213,000
Operating lease, right-of-use assets | $ 83,500,000 | 83,475,000 |  |
Operating lease, lease liabilities | 96,200,000 | 96,673,000 |  |
Cumulative effect adjustment to accumulated deficit |  |  | $ 12,577,000 |
Tax provision on unrealized gain on available-for-sale securities, offset by benefit in continuing operations |  | $ 1,100,000 |  |
India |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Effective income tax rate |  | 29.00% | 31.00% |
ASC 842 [Member] |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Cumulative effect adjustment to accumulated deficit | $ 0 |  |  |
Collaboration Partner [Member] |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Accounts receivable for expense reimbursements from collaboration partner |  | $ 28,400,000 |  | $ 19,000,000

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- Definition Amount due from customers or clients, within one year of the balance sheet date (or the normal operating cycle, whichever is longer), for goods or services (including trade receivables) that have been delivered or sold in the normal course of business, reduced to the estimated net realizable fair value by an allowance established by the entity of the amount it deems uncertain of collection. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 606 -SubTopic 10 -Section 50 -Paragraph 8 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109196051&loc=SL49130549-203045 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02(3)) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
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