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v3.19.1

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) | 3 Months Ended
--- | ---
Mar. 31, 2019 | Mar. 31, 2018
Cash flows from operating activities: |  |
Net loss | $ (118,512,000) | $ (95,792,000)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Non-cash royalty revenue related to sale of future royalties | (8,230,000) | (6,920,000)
Non-cash interest expense on liability related to sale of future royalties | 6,065,000 | 5,019,000
Stock-based compensation | 25,385,000 | 19,949,000
Depreciation and amortization | 3,077,000 | 2,541,000
Accretion of discounts, net and other non-cash transactions | (4,303,000) | (370,000)
Changes in operating assets and liabilities: |  |
Accounts receivable | 319,000 | 151,000
Inventory | (397,000) | 51,000
Other assets | 4,209,000 | 1,853,000
Accounts payable | 5,156,000 | 6,492,000
Accrued compensation | 8,434,000 | 6,867,000
Other accrued expenses | 774,000 | 10,826,000
Deferred revenue | (4,204,000) | (3,678,000)
Other liabilities | 1,332,000 | 545,000
Net cash used in operating activities | (80,895,000) | (52,466,000)
Cash flows from investing activities: |  |
Purchases of investments | (368,739,000) |
Maturities of investments | 362,249,000 | 37,232,000
Sales of investments | 0 | 11,963,000
Purchases of property, plant and equipment | (5,648,000) | (985,000)
Net cash provided by (used in) investing activities | (12,138,000) | 48,210,000
Cash flows from financing activities: |  |
Proceeds from shares issued under equity compensation plans | 4,894,000 | 34,352,000
Net cash provided by financing activities | 4,894,000 | 34,352,000
Effect of exchange rates on cash and cash equivalents | (14,000) | (53,000)
Net increase (decrease) in cash and cash equivalents | (88,153,000) | 30,043,000
Cash and cash equivalents at beginning of period | 194,905,000 | 4,762,000
Cash and cash equivalents at end of period | 106,752,000 | 34,805,000
Supplemental disclosure of cash flow information: |  |
Cash paid for interest | $ 4,805,000 | $ 4,952,000

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