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v3.19.1

Condensed Consolidated Statements of Operations (Unaudited) - USD ($) shares in Thousands, $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2019 | Mar. 31, 2018
Revenue: |  |
Total revenue | $ 28,222 | $ 38,018
Operating costs and expenses: |  |
Cost of goods sold | $ 5,440 | $ 6,646
Type of Cost, Good or Service [Extensible List] | us-gaap:ProductMember | us-gaap:ProductMember
Research and development | $ 118,463 | $ 99,424
General and administrative | 25,006 | 18,687
Total operating costs and expenses | 148,909 | 124,757
Loss from operations | (120,687) | (86,739)
Non-operating income (expense): |  |
Interest expense | (5,226) | (5,340)
Non-cash interest expense on liability related to sale of future royalties | (6,065) | (5,019)
Interest income and other income (expense), net | 12,483 | 1,571
Total non-operating income (expense), net | 1,192 | (8,788)
Loss before provision for income taxes | (119,495) | (95,527)
Provision (benefit) for income taxes | (983) | 265
Net loss | $ (118,512) | $ (95,792)
Basic and diluted net loss per share | $ (0.68) | $ (0.60)
Weighted average shares outstanding used in computing basic and diluted net loss per share | 173,859 | 160,884
Product Sales [Member] |  |
Revenue: |  |
Total revenue | $ 4,398 | $ 6,295
Royalty Revenue [Member] |  |
Revenue: |  |
Total revenue | 11,390 | 11,076
Non-cash Royalty Revenue Related to Sale of Future Royalties [Member] |  |
Revenue: |  |
Total revenue | 8,230 | 6,920
License, Collaboration and Other Revenue [Member] |  |
Revenue: |  |
Total revenue | $ 4,204 | $ 13,727

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