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Income Taxes - Income Tax Provision Related to Continuing Operations (Detail) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017
Income Tax Disclosure [Abstract] |  |  |
Income tax expense (benefit) at federal statutory rate | $ (92,411) | $ 143,372 | $ (33,627)
Research credits | (10,511) | (17,295) | (8,038)
Sale of future royalties | (7,624) | (6,995) | (8,236)
Stock-based compensation | (672) | (66,716) | (20,665)
Premium on equity issuance | 0 | (12,551) | 0
Change in valuation allowance | 104,440 | (46,885) | (186,124)
Non-cash interest expense on liability related to sale of future royalties | 5,259 | 4,451 | 6,604
Non-deductible officers’ compensation | 737 | 3,182 | 2,547
Tax law changes | 23 | 45 | 248,155
Other | 1,372 | 804 | 0
Provision for income taxes | $ 613 | $ 1,412 | $ 616

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- Definition Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to other nondeductible expenses. + References No definition available. + Details
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