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Stock-Based Compensation - Stock-Based Compensation Expense (Detail) - USD ($) $ in Thousands | 3 Months Ended
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Mar. 31, 2020 | Mar. 31, 2019
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |
Total stock-based compensation | $ 25,236 | $ 25,385
Cost of goods sold |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |
Total stock-based compensation | 761 | 820
Research and development |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |
Total stock-based compensation | 15,453 | 16,623
General and administrative |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |
Total stock-based compensation | 7,997 | 7,942
Impairment of assets and other costs for terminated program |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |
Total stock-based compensation | $ 1,025 | $ 0

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- Definition Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. + References No definition available. + Details
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