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Organization and Summary of Significant Accounting Policies - Additional Information (Detail) $ in Thousands |  | 3 Months Ended |  |
--- | --- | --- | --- | ---
Apr. 13, 2020 USD ($) | Mar. 31, 2020 USD ($) Segment | Mar. 31, 2019 USD ($) | Dec. 31, 2019 USD ($) | Oct. 05, 2015 USD ($)
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |
Cash and investments in marketable securities |  | $ 1,531,782 |  | $ 1,603,981 |
Senior secured notes |  | $ 254,800 |  |  |
Tax provision on unrealized gain on available-for-sale securities, offset by benefit in continuing operations |  |  | $ 1,100 |  |
Number of business segment | Segment |  | 1 |  |  |
Accounts receivable for expense reimbursements from collaboration partner |  | $ 42,031 |  | 36,802 |
Operating lease, right-of-use assets |  | 133,901 |  | 134,177 |
7.75% Senior Secured Notes Due October 2020 | Senior Notes |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |
Senior secured notes |  |  |  |  | $ 250,000
7.75% Senior Secured Notes Due October 2020 | Senior Notes | Subsequent Event |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |
Repayments of long term debt, including interest | $ 254,800 |  |  |  |
NKTR - 181 |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |
Write off of prepayment |  | 19,700 |  |  |
Purchase commitment, remaining minimum amount committed |  | 25,500 |  |  |
Collaboration Partner |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |
Accounts receivable for expense reimbursements from collaboration partner |  | 10,900 |  | 12,800 |
BMS Collaboration Agreement |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |
Accounts receivable for expense reimbursements from collaboration partner |  | $ 31,200 |  | $ 24,000 |

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