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v3.20.2

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) | 6 Months Ended
--- | ---
Jun. 30, 2020 | Jun. 30, 2019
Cash flows from operating activities: |  |
Net loss | $ (218,651,000) | $ (229,918,000)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Non-cash royalty revenue related to sale of future royalties | (17,579,000) | (17,321,000)
Non-cash interest expense on liability related to sale of future royalties | 13,659,000 | 12,040,000
Stock-based compensation | 48,607,000 | 49,907,000
Depreciation and amortization | 7,692,000 | 6,132,000
Impairment of advance payments to contract manufacturers and equipment for terminated program | 20,351,000 | 0
Accretion of premiums (discounts), net and other non-cash transactions | (782,000) | (6,329,000)
Changes in operating assets and liabilities: |  |
Accounts receivable | (10,443,000) | 5,914,000
Inventory | 81,000 | (1,807,000)
Operating leases, net | 4,245,000 | 8,415,000
Other assets | (27,214,000) | 15,818,000
Accounts payable | 425,000 | 3,480,000
Accrued compensation | 12,469,000 | 9,773,000
Other accrued expenses | 8,952,000 | 15,794,000
Deferred revenue | (3,790,000) | (6,715,000)
Net cash used in operating activities | (161,978,000) | (134,817,000)
Cash flows from investing activities: |  |
Purchases of investments | (543,631,000) | (603,702,000)
Maturities of investments | 860,330,000 | 634,145,000
Sales of investments | 41,700,000 | 0
Purchases of property, plant and equipment | (3,594,000) | (17,291,000)
Net cash provided by investing activities | 354,805,000 | 13,152,000
Cash flows from financing activities: |  |
Proceeds from shares issued under equity compensation plans | 19,120,000 | 12,200,000
Repayment of senior notes | (250,000,000) | 0
Net cash provided by (used in) financing activities | (230,880,000) | 12,200,000
Effect of foreign exchange rates on cash and cash equivalents | (104,000) | (16,000)
Net decrease in cash and cash equivalents | (38,157,000) | (109,481,000)
Cash and cash equivalents at beginning of period | 96,363,000 | 194,905,000
Cash and cash equivalents at end of period | 58,206,000 | 85,424,000
Supplemental disclosures of cash flow information: |  |
Cash paid for interest | 9,742,000 | 9,455,000
Operating lease right-of-use asset recognized in exchange for lease liabilities | $ 2,133,000 | $ 1,289,000

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