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v3.20.2

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) | 9 Months Ended
--- | ---
Sep. 30, 2020 | Sep. 30, 2019
Cash flows from operating activities: |  |
Net loss | $ (327,237,000) | $ (328,503,000)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Non-cash royalty revenue related to sale of future royalties | (28,001,000) | (27,585,000)
Non-cash interest expense on liability related to sale of future royalties | 22,084,000 | 17,853,000
Stock-based compensation | 72,274,000 | 74,787,000
Depreciation and amortization | 10,937,000 | 9,582,000
Impairment of advance payments to contract manufacturers and equipment for terminated program | 20,351,000 | 0
Accretion of premiums (discounts), net and other non-cash transactions | 1,150,000 | (9,147,000)
Changes in operating assets and liabilities: |  |
Accounts receivable | (6,123,000) | 2,008,000
Inventory | (227,000) | (2,339,000)
Operating leases, net | 4,316,000 | 11,550,000
Other assets | (5,588,000) | 18,127,000
Accounts payable | (3,337,000) | 16,109,000
Accrued compensation | 20,478,000 | 13,164,000
Other accrued expenses | 9,340,000 | 10,401,000
Deferred revenue | (5,070,000) | (9,465,000)
Net cash used in operating activities | (214,653,000) | (203,458,000)
Cash flows from investing activities: |  |
Purchases of investments | (791,445,000) | (1,028,883,000)
Maturities of investments | 1,158,722,000 | 1,122,902,000
Sales of investments | 41,700,000 | 0
Purchases of property, plant and equipment | (5,504,000) | (22,614,000)
Net cash provided by investing activities | 403,473,000 | 71,405,000
Cash flows from financing activities: |  |
Proceeds from shares issued under equity compensation plans | 20,651,000 | 18,449,000
Repayment of senior notes | (250,000,000) | 0
Net cash provided by (used in) financing activities | (229,349,000) | 18,449,000
Effect of foreign exchange rates on cash and cash equivalents | 9,000 | (77,000)
Net decrease in cash and cash equivalents | (40,520,000) | (113,681,000)
Cash and cash equivalents at beginning of period | 96,363,000 | 194,905,000
Cash and cash equivalents at end of period | 55,843,000 | 81,224,000
Supplemental disclosures of cash flow information: |  |
Cash paid for interest | 9,742,000 | 14,299,000
Operating lease right-of-use asset recognized in exchange for lease liabilities | $ 2,133,000 | $ 56,025,000

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