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Income Taxes - Income Tax Provision Related to Continuing Operations (Detail) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Income Tax Disclosure [Abstract] |  |  |
Income tax expense (benefit) at federal statutory rate | $ (93,229) | $ (92,411) | $ 143,372
Research credits | (3,081) | (10,511) | (17,295)
Premium on equity issuance | 0 | 0 | (12,551)
Change in valuation allowance | 87,060 | 104,440 | (46,885)
Stock-based compensation | 7,929 | (672) | (66,716)
Non-cash royalty revenue related to sale of future royalties | (7,967) | (7,624) | (6,995)
Non-cash interest expense on liability related to sale of future royalties | 6,356 | 5,259 | 4,451
Other | 3,425 | 2,132 | 4,031
Provision for income taxes | $ 493 | $ 613 | $ 1,412

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- Definition Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to other nondeductible expenses. + References No definition available. + Details
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