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Organization and Summary of Significant Accounting Policies (Detail) $ in Thousands, shares in Millions |  | 12 Months Ended |
--- | --- | --- | ---
Apr. 13, 2020 USD ($) | Dec. 31, 2020 USD ($) reporting_unit shares | Dec. 31, 2019 USD ($) shares | Dec. 31, 2018 shares | Mar. 31, 2020 USD ($)
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |
Cash and investments in marketable securities |  | $ 1,198,558 | $ 1,603,981 |  |
Net expense reimbursements from collaboration partner |  | 38,700 | 24,000 |  |
Contract with customer, asset, reclassified to receivable |  | $ 200 | 12,800 |  |
Estimate for royalties resulting from net sales |  |  | $ 11,600 |  |
Number of reporting unit evaluated for goodwill | reporting_unit |  | 1 |  |  |
Purchase commitments related to contract manufacturing, clinical development and certain other items |  | $ 8,000 |  |  |
Weighted-average of potentially dilutive securities (stock options and RSUs) included in calculation of diluted securities under treasury stock method (in shares) | shares |  |  |  | 10.5 |
Accounts Receivable | Customer Concentration Risk | Partner One |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |
Percentage revenue from customers |  |  | 65.00% |  |
Accounts Receivable | Customer Concentration Risk | Partner Two |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |
Percentage revenue from customers |  |  | 17.00% |  |
Accounts Receivable | Customer Concentration Risk | Partner Three |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |
Percentage revenue from customers |  |  | 14.00% |  |
NKTR - 181 |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |
Write off of prepayment |  |  |  |  | $ 19,700
Purchase commitments related to contract manufacturing, clinical development and certain other items |  |  |  |  | $ 25,500
7.75 Percent Senior Secured Notes Due October 2020 | Senior Notes |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |
Principal and interest repaid on senior notes | $ 254,800 |  |  |  |
Shares of Common Stock Underlying Outstanding Stock Options |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |
Weighted average antidilutive securities excluded from computation of earnings per share | shares |  |  |  | 3.3 |
Stock Options and Restricted Stock Units |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |
Weighted average antidilutive securities excluded from computation of earnings per share | shares |  | 17.4 | 17.9 |  |
Manufacturing equipment | Minimum |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |
Property and equipment estimated useful lives |  | 3 years |  |  |
Manufacturing equipment | Maximum |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |
Property and equipment estimated useful lives |  | 10 years |  |  |
Buildings |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |
Property and equipment estimated useful lives |  | 20 years |  |  |

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