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Consolidated Statements of Cash Flows - USD ($) | 12 Months Ended | 106 Months Ended
--- | --- | ---
Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2020
Cash flows from operating activities: |  |  |  |
Net income (loss) | $ (444,440,000) | $ (440,667,000) | $ 681,313,000 |
Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities: |  |  |  |
Non-cash royalty revenue related to sale of future royalties | (48,563,000) | (36,303,000) | (33,308,000) | $ (255,705,000)
Non-cash interest expense on liability related to sale of future royalties | 30,267,000 | 25,044,000 | 21,196,000 | 196,960,000
Stock-based compensation | 94,261,000 | 99,795,000 | 88,101,000 |
Depreciation and amortization | 14,182,000 | 13,156,000 | 10,870,000 |
Impairment of advance payments to contract manufacturers and equipment for terminated program | 20,351,000 | 0 | 0 |
Accretion of premiums (discounts), net and other non-cash transactions | 3,943,000 | (11,394,000) | (10,952,000) |
Changes in operating assets and liabilities |  |  |  |
Accounts receivable | 1,913,000 | 6,411,000 | (25,505,000) |
Inventory | (2,627,000) | (1,284,000) | (655,000) |
Operating leases, net | 2,743,000 | 13,090,000 | 0 |
Other assets | 4,476,000 | 1,190,000 | (31,652,000) |
Accounts payable | 2,382,000 | 12,967,000 | 971,000 |
Accrued compensation | 4,697,000 | 1,530,000 | 1,674,000 |
Other accrued expenses | 8,644,000 | 4,349,000 | 31,492,000 |
Deferred revenue | (5,516,000) | (16,565,000) | (15,331,000) |
Net cash provided by (used in) operating activities | (313,287,000) | (328,681,000) | 718,214,000 |
Cash flows from investing activities: |  |  |  |
Purchases of investments | (987,533,000) | (1,380,865,000) | (2,271,250,000) |
Maturities of investments | 1,449,304,000 | 1,614,036,000 | 890,957,000 |
Sales of investments | 41,700,000 | 0 | 11,963,000 |
Purchases of property, plant and equipment | (7,258,000) | (26,285,000) | (14,239,000) |
Sales of property and plant | 0 | 0 | 2,633,000 |
Net cash provided by (used in) investing activities | 496,213,000 | 206,886,000 | (1,379,936,000) |
Cash flows from financing activities: |  |  |  |
Issuance of common stock to Bristol-Myers Squibb (Note 10) | 0 | 0 | 790,231,000 |
Proceeds from sale of future royalties, net of $3.8 million of transaction costs | 146,250,000 | 0 | 0 |
Repayment of senior notes | (250,000,000) | 0 | 0 |
Proceeds from shares issued under equity compensation plans | 23,396,000 | 23,355,000 | 61,735,000 |
Net cash provided by (used in) financing activities | (80,354,000) | 23,355,000 | 851,966,000 |
Effect of exchange rates on cash and cash equivalents | 20,000 | (102,000) | (101,000) |
Net increase (decrease) in cash and cash equivalents | 102,592,000 | (98,542,000) | 190,143,000 |
Cash and cash equivalents at beginning of year | 96,363,000 | 194,905,000 | 4,762,000 |
Cash and cash equivalents at end of year | 198,955,000 | 96,363,000 | 194,905,000 | $ 198,955,000
Supplemental disclosure of cash flow information: |  |  |  |
Cash paid for interest | 9,742,000 | 19,199,000 | 19,471,000 |
Cash paid for income taxes | 539,000 | 555,000 | 618,000 |
Operating lease right-of-use assets recognized in exchange for lease liabilities | $ 2,133,000 | $ 57,691,000 | $ 0 |

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