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Liabilities Related to the Sales of Future Royalties - Summary of Liability Related to Potential Future Royalties (Detail) - USD ($) $ in Thousands |  | 12 Months Ended | 106 Months Ended
--- | --- | --- | ---
Dec. 31, 2020 | Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2020
Liability Related to the Sale of Future Royalties [Line Items] |  |  |  |  |
Liability related to the sale of future royalties—beginning balance |  | $ 73,551 |  |  | $ 0
Royalty monetization proceeds |  | 150,000 |  |  | 274,000
Non-cash royalty revenue |  | 48,563 | $ 36,303 | $ 33,308 | 255,705
Non-cash interest expense |  | 30,267 | 25,044 | $ 21,196 | 196,960
Payments to RPI |  | 0 |  |  | (10,000)
Liability related to the sale of future royalties – ending balance | $ 205,255 | 205,255 | 73,551 |  | 205,255
Less: unamortized transaction costs | (4,915) | (4,915) |  |  | (4,915)
Liability related to the sale of future royalties, net | 200,340 | 200,340 | 72,020 |  | 200,340
Purchase and Sale Agreement 2012 |  |  |  |  |
Liability Related to the Sale of Future Royalties [Line Items] |  |  |  |  |
Liability related to the sale of future royalties—beginning balance |  | 73,551 |  |  | 0
Royalty monetization proceeds |  | 0 |  |  | 124,000
Non-cash royalty revenue |  | 37,938 |  |  | 245,080
Non-cash interest expense |  | 30,267 |  |  | 196,960
Payments to RPI |  | 0 |  |  | (10,000)
Liability related to the sale of future royalties – ending balance | 65,880 | 65,880 | $ 73,551 |  | 65,880
Less: unamortized transaction costs | (1,165) | (1,165) |  |  | (1,165)
Liability related to the sale of future royalties, net | 64,715 | $ 64,715 |  |  | 64,715
Implicit interest rate over the life of the agreement |  | 20.20% | 19.50% | 18.70% |
Prospective effective interest rate |  | 48.00% | 38.00% | 29.00% |
Purchase and Sale Agreement 2020 |  |  |  |  |
Liability Related to the Sale of Future Royalties [Line Items] |  |  |  |  |
Liability related to the sale of future royalties—beginning balance | 0 | $ 0 |  |  |
Royalty monetization proceeds | 150,000 | 150,000 |  |  |
Non-cash royalty revenue | 10,625 | 10,625 |  |  |
Non-cash interest expense | 0 | 0 |  |  |
Payments to RPI | 0 | 0 |  |  |
Liability related to the sale of future royalties – ending balance | 139,375 | 139,375 | $ 0 |  | 139,375
Less: unamortized transaction costs | (3,750) | (3,750) |  |  | (3,750)
Liability related to the sale of future royalties, net | $ 135,625 | $ 135,625 |  |  | $ 135,625
Implicit interest rate over the life of the agreement |  |  |  | 16.00% |
Prospective effective interest rate |  |  |  | 16.00% |

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- Definition Liability related to sale of future royalties. + References No definition available. + Details
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