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Income Taxes - Significant Components of Deferred Tax Assets and Liabilities (Detail) - USD ($) $ in Thousands | Dec. 31, 2020 | Dec. 31, 2019
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 456,284 | $ 399,361
Research and other credits | 132,994 | 128,015
Operating lease liabilities | 35,672 | 36,907
Liability related to the sale of future royalties | 32,737 | 0
Stock-based compensation | 32,517 | 30,875
Other | 11,688 | 13,568
Deferred tax assets before valuation allowance | 701,892 | 608,726
Valuation allowance for deferred tax assets | (670,103) | (575,087)
Total deferred tax assets | 31,789 | 33,639
Deferred tax liabilities: |  |
Operating lease right-of-use assets | (29,707) | (31,718)
Other | (1,856) | (1,725)
Total deferred tax liabilities | (31,563) | (33,443)
Net deferred tax assets | $ 226 | $ 196

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