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v3.20.4

Consolidated Statements of Stockholders' Equity - USD ($) shares in Thousands, $ in Thousands | Total | Cumulative Effect, Period of Adoption, Adjustment | Common Stock | Capital in Excess of Par Value | Accumulated Other Comprehensive Income/(Loss) | Accumulated Deficit | Accumulated Deficit Cumulative Effect, Period of Adoption, Adjustment
--- | --- | --- | --- | --- | --- | --- | ---
Beginning Balance (in shares) at Dec. 31, 2017 |  |  | 159,524 |  |  |  |
Beginning Balance at Dec. 31, 2017 | $ 87,828 | $ 12,577 | $ 15 | $ 2,207,865 | $ (2,111) | $ (2,117,941) | $ 12,577
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |
Shares issued under equity compensation plans (in shares) |  |  | 5,721 |  |  |  |
Shares issued under equity compensation plans | 61,729 |  | $ 1 | 61,728 |  |  |
Stock-based compensation | 88,101 |  |  | 88,101 |  |  |
Sale of stock to Bristol-Myers Squibb (Note 10) (in shares) |  |  | 8,285 |  |  |  |
Sale of stock to Bristol-Myers Squibb (Note 10) | 790,232 |  | $ 1 | 790,231 |  |  |
Comprehensive income (loss) | 677,108 |  |  |  | (4,205) | 681,313 |
Ending Balance (in shares) at Dec. 31, 2018 |  |  | 173,530 |  |  |  |
Ending Balance at Dec. 31, 2018 | 1,717,575 |  | $ 17 | 3,147,925 | (6,316) | (1,424,051) |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |
Shares issued under equity compensation plans (in shares) |  |  | 2,975 |  |  |  |
Shares issued under equity compensation plans | 23,377 |  |  | 23,377 |  |  |
Stock-based compensation | 99,795 |  |  | 99,795 |  |  |
Comprehensive income (loss) | (435,356) |  |  |  | 5,311 | (440,667) |
Ending Balance (in shares) at Dec. 31, 2019 |  |  | 176,505 |  |  |  |
Ending Balance at Dec. 31, 2019 | 1,405,391 |  | $ 17 | 3,271,097 | (1,005) | (1,864,718) |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |
Shares issued under equity compensation plans (in shares) |  |  | 3,586 |  |  |  |
Shares issued under equity compensation plans | 23,373 |  | $ 1 | 23,372 |  |  |
Stock-based compensation | 94,261 |  |  | 94,261 |  |  |
Comprehensive income (loss) | (445,730) |  |  |  | (1,290) | (444,440) |
Ending Balance (in shares) at Dec. 31, 2020 |  |  | 180,091 |  |  |  |
Ending Balance at Dec. 31, 2020 | $ 1,077,295 |  | $ 18 | $ 3,388,730 | $ (2,295) | $ (2,309,158) |

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