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v3.21.1

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2021 | Mar. 31, 2020
Cash flows from operating activities: |  |
Net loss | $ (122,967) | $ (138,651)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Non-cash royalty revenue related to sale of future royalties | (18,798) | (9,895)
Change in fair value of development derivative liability | 13,296 | 6,968
Change in fair value of development derivative liability | 1,599 | 0
Non-cash research and development expense | 2,248 | 0
Stock-based compensation | 23,898 | 25,236
Depreciation and amortization | 3,543 | 4,502
Impairment of advance payments to contract manufacturers and equipment for terminated program | 0 | 20,351
Amortization of premiums (discounts), net and other non-cash transactions | 2,345 | (1,289)
Changes in operating assets and liabilities: |  |
Accounts receivable | 9,733 | (5,229)
Inventory | (1,516) | (1,655)
Operating leases, net | 1,541 | 2,940
Other assets | 6,183 | 1,067
Accounts payable | 779 | 2,687
Accrued compensation | 8,981 | 9,920
Other accrued expenses | (7,345) | 7,483
Deferred revenue | (605) | (2,510)
Net cash used in operating activities | (77,085) | (78,075)
Cash flows from investing activities: |  |
Purchases of investments | (295,314) | (241,068)
Maturities of investments | 303,612 | 439,735
Sales of investments | 5,036 | 0
Purchases of property, plant and equipment | (2,876) | (900)
Net cash provided by investing activities | 10,458 | 197,767
Cash flows from financing activities: |  |
Proceeds from shares issued under equity compensation plans | 17,106 | 11,077
Cash receipts from development derivative liability | 750 | 0
Net cash provided by financing activities | 17,856 | 11,077
Effect of foreign exchange rates on cash and cash equivalents | (20) | (97)
Net increase (decrease) in cash and cash equivalents | (48,791) | 130,672
Cash and cash equivalents at beginning of period | 198,955 | 96,363
Cash and cash equivalents at end of period | 150,164 | 227,035
Supplemental disclosures of cash flow information: |  |
Cash paid for interest | 0 | 4,951
Operating lease right-of-use asset recognized in exchange for lease liabilities | $ 1,057 | $ 2,133

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