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Fair Value Measurement (Details) - USD ($) $ in Thousands | Mar. 31, 2021 | Dec. 31, 2020
--- | --- | ---
Level 2 |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Available-for-sale investments | $ 993,989 | $ 1,003,348
Recurring |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Total assets | 1,117,596 | 1,182,650
Development derivative liability | 4,597 | 0
Recurring | Corporate notes and bonds |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Available-for-sale investments | 510,663 | 687,469
Recurring | Corporate commercial paper |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Available-for-sale investments | 478,442 | 313,497
Recurring | Obligations of U.S. government agencies |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Available-for-sale investments | 4,884 | 2,382
Recurring | Money market funds |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Investments in marketable securities | 123,607 | 179,302
Recurring | Level 1 |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Total assets | 123,607 | 179,302
Development derivative liability | 0 | 0
Recurring | Level 1 | Corporate notes and bonds |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Available-for-sale investments | 0 | 0
Recurring | Level 1 | Corporate commercial paper |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Available-for-sale investments | 0 | 0
Recurring | Level 1 | Obligations of U.S. government agencies |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Available-for-sale investments | 0 | 0
Recurring | Level 1 | Money market funds |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Investments in marketable securities | 123,607 | 179,302
Recurring | Level 2 |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Total assets | 993,989 | 1,003,348
Development derivative liability | 0 | 0
Recurring | Level 2 | Corporate notes and bonds |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Available-for-sale investments | 510,663 | 687,469
Recurring | Level 2 | Corporate commercial paper |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Available-for-sale investments | 478,442 | 313,497
Recurring | Level 2 | Obligations of U.S. government agencies |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Available-for-sale investments | 4,884 | 2,382
Recurring | Level 2 | Money market funds |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Investments in marketable securities | 0 | 0
Recurring | Level 3 |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Total assets | 0 | 0
Development derivative liability | 4,597 | 0
Recurring | Level 3 | Corporate notes and bonds |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Available-for-sale investments | 0 | 0
Recurring | Level 3 | Corporate commercial paper |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Available-for-sale investments | 0 | 0
Recurring | Level 3 | Obligations of U.S. government agencies |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Available-for-sale investments | 0 | 0
Recurring | Level 3 | Money market funds |  |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] |  |
Investments in marketable securities | $ 0 | $ 0

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