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Organization and Summary of Significant Accounting Policies - Additional Information (Detail) | 6 Months Ended |  |
--- | --- | --- | ---
Jun. 30, 2021 USD ($) segment | Dec. 31, 2020 USD ($) | Mar. 31, 2020 USD ($)
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |
Cash and investments in marketable securities | $ 1,057,462,000 | $ 1,198,558,000 |
Number of business segment | segment | 1 |  |
Accounts receivable | $ 28,871,000 | 38,889,000 |
Allowance for credit loss | 0 | 0 |
Aggregate offering price | 300,000,000.0 |  |
NKTR - 181 |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |
Write off of prepayment |  |  | $ 19,700,000
Purchase commitment, remaining minimum amount committed |  |  | $ 25,500,000
Bristol Myers Squibb Collaboration Agreement |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |
Accounts receivable | 25,000,000.0 | 38,700,000 |
Collaboration Partner |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |
Accounts receivable | $ 3,400,000 | $ 200,000 |

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