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v3.21.2

Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2021 | Jun. 30, 2020
Cash flows from operating activities: |  |
Net loss | $ (248,486) | $ (218,651)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Non-cash royalty revenue related to sale of future royalties | (39,254) | (17,579)
Non-cash interest expense on liability related to sale of future royalties | 26,385 | 13,659
Change in fair value of development derivative liability | 4,312 | 0
Non-cash research and development expense | 5,795 | 0
Stock-based compensation | 47,612 | 48,607
Depreciation and amortization | 7,090 | 7,692
Impairment of advance payments to contract manufacturers and equipment for terminated program | 0 | 20,351
Amortization of premiums (discounts), net and other non-cash transactions | 4,090 | (782)
Changes in operating assets and liabilities: |  |
Accounts receivable | 10,018 | (10,443)
Inventory | 676 | 81
Operating leases, net | 2,260 | 4,245
Other assets | 11,585 | (27,214)
Accounts payable | (2,101) | 425
Accrued compensation | 14,133 | 12,469
Other accrued expenses | (3,496) | 8,952
Deferred revenue | (605) | (3,790)
Net cash used in operating activities | (159,986) | (161,978)
Cash flows from investing activities: |  |
Purchases of investments | (527,887) | (543,631)
Maturities of investments | 612,419 | 860,330
Sales of investments | 5,035 | 41,700
Purchases of property, plant and equipment | (6,157) | (3,594)
Net cash provided by investing activities | 83,410 | 354,805
Cash flows from financing activities: |  |
Proceeds from shares issued under equity compensation plans | 28,523 | 19,120
Cash receipts from development derivative liability | 1,500 | 0
Repayment of senior notes | 0 | (250,000)
Net cash provided by (used in) financing activities | 30,023 | (230,880)
Effect of foreign exchange rates on cash and cash equivalents | (57) | (104)
Net decrease in cash and cash equivalents | (46,610) | (38,157)
Cash and cash equivalents at beginning of period | 198,955 | 96,363
Cash and cash equivalents at end of period | 152,345 | 58,206
Supplemental disclosures of cash flow information: |  |
Cash paid for interest | 0 | 9,742
Operating lease right-of-use asset recognized in exchange for lease liabilities | $ 1,057 | $ 2,133

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