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v3.21.2

Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2021 | Sep. 30, 2020
Cash flows from operating activities: |  |
Net loss | $ (378,192) | $ (327,237)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Non-cash royalty revenue related to sales of future royalties | (58,667) | (28,001)
Non-cash interest expense on liabilities related to sales of future royalties | 39,186 | 22,084
Change in fair value of development derivative liability | 7,640 | 0
Non-cash research and development expense | 11,497 | 0
Stock-based compensation | 72,269 | 72,274
Depreciation and amortization | 10,710 | 10,937
Impairment of advance payments to contract manufacturers and equipment for terminated program | 0 | 20,351
Amortization of premiums (discounts), net and other non-cash transactions | 5,677 | 1,150
Changes in operating assets and liabilities: |  |
Accounts receivable | 9,895 | (6,123)
Inventory | (38) | (227)
Operating leases, net | 2,932 | 4,316
Other assets | 814 | (5,588)
Accounts payable | 1,247 | (3,337)
Accrued compensation | 18,350 | 20,478
Other accrued expenses | (3,837) | 9,340
Deferred revenue | (605) | (5,070)
Net cash used in operating activities | (261,122) | (214,653)
Cash flows from investing activities: |  |
Purchases of investments | (816,049) | (791,445)
Maturities of investments | 902,687 | 1,158,722
Sales of investments | 5,035 | 41,700
Purchases of property, plant and equipment | (9,093) | (5,504)
Net cash provided by investing activities | 82,580 | 403,473
Cash flows from financing activities: |  |
Proceeds from shares issued under equity compensation plans | 31,436 | 20,651
Cash receipts from development derivative liability | 2,250 | 0
Repayment of senior notes | 0 | (250,000)
Net cash provided by (used in) financing activities | 33,686 | (229,349)
Effect of foreign exchange rates on cash and cash equivalents | (82) | 9
Net decrease in cash and cash equivalents | (144,938) | (40,520)
Cash and cash equivalents at beginning of period | 198,955 | 96,363
Cash and cash equivalents at end of period | 54,017 | 55,843
Supplemental disclosures of cash flow information: |  |
Cash paid for interest | 0 | 9,742
Operating lease right-of-use asset recognized in exchange for lease liabilities | $ 1,057 | $ 2,133

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