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Cash and Investments in Marketable Securities (Tables)
9 Months Ended
Sep. 30, 2021
Fair Value Disclosures [Abstract]  
Cash and Investments in Marketable Securities, Including Cash Equivalents Cash and investments in marketable securities, including cash equivalents, are as follows (in thousands):
Estimated Fair Value at
September 30, 2021December 31, 2020
Cash and cash equivalents$54,017 $198,955 
Short-term investments867,063 862,941 
Long-term investments34,219 136,662 
Total cash and investments in marketable securities$955,299 $1,198,558 
Portfolio of Cash and Investments in Marketable Securities Our portfolio of cash and investments in marketable securities includes (in thousands):
September 30, 2021December 31, 2020
Amortized CostGross Unrealized GainsGross Unrealized LossesFair ValueFair Value
Corporate notes and bonds$329,376 $53 $(90)$329,339 $687,469 
Corporate commercial paper555,989 35 (100)555,924 313,497 
Obligations of U.S. government agencies5,880 — 5,882 2,382 
Available-for-sale investments$891,245 $90 $(190)$891,145 $1,003,348 
Money market funds48,336 179,302 
Certificates of deposit10,137 9,623 
Cash5,681 6,285 
Total cash and investments in marketable securities$955,299 $1,198,558