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Liabilities Related to Sales of Future Royalties - Estimates of Annual Interest Rate (Details)	3 Months Ended		9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
2012 Purchase and Sale Agreement
Liability Related to Sale of Future Royalties [Line Items]
Implicit interest rate over the life of the agreement	20.20%	20.20%	20.20%	20.20%
Prospective effective interest rate	48.00%	48.00%	48.00%	48.00%
2020 Purchase and Sale Agreement
Liability Related to Sale of Future Royalties [Line Items]
Implicit interest rate over the life of the agreement	16.00%		16.00%
Prospective effective interest rate	16.00%		16.00%