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Condensed Consolidated Statements of Operations - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2021
Sep. 30, 2020
Sep. 30, 2021
Sep. 30, 2020
Revenue:        
Total revenue $ 24,921 $ 30,033 $ 76,898 $ 129,453
Operating costs and expenses:        
Cost of goods sold 5,311 5,570 18,734 15,154
Research and development 103,738 100,531 300,655 305,954
General and administrative 29,468 26,982 90,702 77,546
Impairment of assets and other costs for terminated program 0 0 0 45,189
Total operating costs and expenses 138,517 133,083 410,091 443,843
Loss from operations (113,596) (103,050) (333,193) (314,390)
Non-operating income (expense):        
Non-cash interest expense on liabilities related to sales of future royalties (12,801) (8,425) (39,186) (22,084)
Change in fair value of development derivative liability (3,328) 0 (7,640) 0
Interest income and other income (expense), net 131 2,910 2,388 16,453
Interest expense 0 0 0 (6,851)
Total non-operating income (expense), net (15,998) (5,515) (44,438) (12,482)
Loss before provision for income taxes (129,594) (108,565) (377,631) (326,872)
Provision for income taxes 112 21 561 365
Net loss $ (129,706) $ (108,586) $ (378,192) $ (327,237)
Basic net loss per share (in dollars per share) $ (0.70) $ (0.61) $ (2.07) $ (1.84)
Diluted net loss per share (in dollars per share) $ (0.70) $ (0.61) $ (2.07) $ (1.84)
Weighted average shares outstanding used in computing basic net loss per share (in shares) 184,110 179,090 182,736 178,203
Weighted average shares outstanding used in computing diluted net loss per share (in shares) 184,110 179,090 182,736 178,203
Product sales        
Revenue:        
Total revenue $ 5,194 $ 5,691 $ 17,835 $ 14,620
Royalty revenue        
Revenue:        
Total revenue 0 12,289 0 31,411
Non-cash royalty revenue related to sales of future royalties        
Revenue:        
Total revenue 19,413 10,422 58,667 28,001
License, collaboration and other revenue        
Revenue:        
Total revenue $ 314 $ 1,631 $ 396 $ 55,421