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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2021
Sep. 30, 2020
Cash flows from operating activities:    
Net loss $ (378,192) $ (327,237)
Adjustments to reconcile net loss to net cash used in operating activities:    
Non-cash royalty revenue related to sales of future royalties (58,667) (28,001)
Non-cash interest expense on liabilities related to sales of future royalties 39,186 22,084
Change in fair value of development derivative liability 7,640 0
Non-cash research and development expense 11,497 0
Stock-based compensation 72,269 72,274
Depreciation and amortization 10,710 10,937
Impairment of advance payments to contract manufacturers and equipment for terminated program 0 20,351
Amortization of premiums (discounts), net and other non-cash transactions 5,677 1,150
Changes in operating assets and liabilities:    
Accounts receivable 9,895 (6,123)
Inventory (38) (227)
Operating leases, net 2,932 4,316
Other assets 814 (5,588)
Accounts payable 1,247 (3,337)
Accrued compensation 18,350 20,478
Other accrued expenses (3,837) 9,340
Deferred revenue (605) (5,070)
Net cash used in operating activities (261,122) (214,653)
Cash flows from investing activities:    
Purchases of investments (816,049) (791,445)
Maturities of investments 902,687 1,158,722
Sales of investments 5,035 41,700
Purchases of property, plant and equipment (9,093) (5,504)
Net cash provided by investing activities 82,580 403,473
Cash flows from financing activities:    
Proceeds from shares issued under equity compensation plans 31,436 20,651
Cash receipts from development derivative liability 2,250 0
Repayment of senior notes 0 (250,000)
Net cash provided by (used in) financing activities 33,686 (229,349)
Effect of foreign exchange rates on cash and cash equivalents (82) 9
Net decrease in cash and cash equivalents (144,938) (40,520)
Cash and cash equivalents at beginning of period 198,955 96,363
Cash and cash equivalents at end of period 54,017 55,843
Supplemental disclosures of cash flow information:    
Cash paid for interest 0 9,742
Operating lease right-of-use asset recognized in exchange for lease liabilities $ 1,057 $ 2,133