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Organization and Summary of Significant Accounting Policies (Details) shares in Millions | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2021 USD ($) | Sep. 30, 2021 USD ($) | Jun. 30, 2021 USD ($) | Mar. 31, 2021 USD ($) | Dec. 31, 2020 USD ($) | Sep. 30, 2020 USD ($) | Jun. 30, 2020 USD ($) | Mar. 31, 2020 USD ($) | Dec. 31, 2021 USD ($) reporting_unit shares | Dec. 31, 2020 USD ($) shares | Dec. 31, 2019 USD ($) shares
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |
Cash and investments in marketable securities | $ 798,783,000 |  |  |  | $ 1,198,558,000 |  |  |  | $ 798,783,000 | $ 1,198,558,000 |
Net expense reimbursements from collaboration partner |  |  |  |  |  |  |  |  | $ 21,400,000 | 38,700,000 |
Number of reporting unit evaluated for goodwill | reporting_unit |  |  |  |  |  |  |  |  | 1 |  |
Total revenue | 25,009,000 | $ 24,921,000 | $ 28,330,000 | $ 23,647,000 | $ 23,462,000 | $ 30,033,000 | $ 48,847,000 | $ 50,573,000 | $ 101,907,000 | 152,915,000 | $ 114,617,000
Purchase commitments related to contract manufacturing, clinical development and certain other items | $ 8,200,000 |  |  |  |  |  |  |  | $ 8,200,000 |  |
BMS Collaboration Agreement |  |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |
Sales milestone revenue |  |  |  |  |  |  |  |  |  | $ 50,000,000 |
Stock Options, RSUs and PSUs |  |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |
Weighted average antidilutive securities excluded from computation of earnings per share (in shares) | shares |  |  |  |  |  |  |  |  | 18.4 | 17.4 | 17.9
NKTR - 181 |  |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |
Write off of prepayment |  |  |  |  |  |  |  | 19,700,000 |  |  |
Purchase commitments related to contract manufacturing, clinical development and certain other items |  |  |  |  |  |  |  | $ 25,500,000 |  |  |
Non-cash royalty revenue related to the sales of future royalties |  |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |
Total revenue |  |  |  |  |  |  |  |  | $ 77,746,000 | $ 48,563,000 | $ 36,303,000
Cash And NonCash Royalties |  |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |
Total revenue |  |  |  |  |  |  |  |  | $ 77,700,000 | $ 79,600,000 | $ 77,500,000
Buildings |  |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |
Property and equipment estimated useful lives |  |  |  |  |  |  |  |  | 20 years |  |
Minimum | Manufacturing equipment |  |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |
Property and equipment estimated useful lives |  |  |  |  |  |  |  |  | 3 years |  |
Maximum | Manufacturing equipment |  |  |  |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |
Property and equipment estimated useful lives |  |  |  |  |  |  |  |  | 10 years |  |

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