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Liabilities Related to the Sales of Future Royalties - Additional Information (Details) $ in Thousands |  |  |  | 1 Months Ended | 3 Months Ended | 12 Months Ended
--- | --- | --- | --- | --- | --- | ---
Dec. 30, 2020 USD ($) | Dec. 16, 2020 USD ($) | Feb. 24, 2012 USD ($) | Mar. 31, 2014 USD ($) | Mar. 31, 2013 USD ($) | Dec. 31, 2021 USD ($) | Dec. 31, 2021 USD ($) | Dec. 31, 2020 USD ($) | Dec. 31, 2019 USD ($)
Liability Related to the Sale of Future Royalties [Line Items] |  |  |  |  |  |  |  |  |
Loss on revaluation of liability related to the sale of future royalties |  |  |  |  |  |  | $ 24,410 | $ 0 | $ 0
2012 Purchase and Sale Agreement |  |  |  |  |  |  |  |  |
Liability Related to the Sale of Future Royalties [Line Items] |  |  |  |  |  |  |  |  |
Proceeds from sale of royalty rights |  |  | $ 124,000 |  |  |  |  |  |
2012 Purchase and Sale Agreement | Future Royalties |  |  |  |  |  |  |  |  |
Liability Related to the Sale of Future Royalties [Line Items] |  |  |  |  |  |  |  |  |
Fair value of liabilities |  |  |  |  |  | $ 84,700 | $ 84,700 |  |
Loss on revaluation of liability related to the sale of future royalties |  |  |  |  |  | 23,500 |  |  |
Transaction costs related to revised royalty payments |  |  |  |  |  | $ 900 |  |  |
2012 Purchase and Sale Agreement | Future Royalties | Measurement Input, Discount Rate |  |  |  |  |  |  |  |  |
Liability Related to the Sale of Future Royalties [Line Items] |  |  |  |  |  |  |  |  |
Royalties liability, measurement input |  |  |  |  |  | 0.160 | 0.160 |  |
2020 Purchase and Sale Agreement |  |  |  |  |  |  |  |  |
Liability Related to the Sale of Future Royalties [Line Items] |  |  |  |  |  |  |  |  |
Proceeds from sale of royalty rights | $ 150,000 |  |  |  |  |  |  |  |
Payment of transaction related to purchase and sale agreement |  | $ 210,000 |  |  |  |  |  |  |
Payment of transaction related to purchase and sale agreement if threshold is not achieved |  | 240,000 |  |  |  |  |  |  |
Minimum transaction royalties payments needed to pay the difference between the 2025 threshold and 2020 transaction royalties |  | $ 208,000 |  |  |  |  |  |  |
Transaction costs related to sale of potential future royalties | $ 3,800 |  |  |  |  |  |  |  |
2020 Purchase and Sale Agreement | Measurement Input, Interest Rate |  |  |  |  |  |  |  |  |
Liability Related to the Sale of Future Royalties [Line Items] |  |  |  |  |  |  |  |  |
Royalties liability, measurement input |  |  |  |  |  | 0.15 | 0.15 |  |
Pursuant to the 2012 Purchase and Sale Agreement |  |  |  |  |  |  |  |  |
Liability Related to the Sale of Future Royalties [Line Items] |  |  |  |  |  |  |  |  |
Payment made for milestone not achieved year two |  |  |  | $ 7,000 |  |  |  |  |
Payment made for milestone not achieved year one |  |  |  |  | $ 3,000 |  |  |  |

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