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Property, Plant and Equipment - Schedule of Property, Plant and Equipment (Details) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020
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Property, Plant and Equipment [Line Items] |  |
Depreciable property, plant and equipment at cost | $ 201,386 | $ 193,450
Less: accumulated depreciation | (148,039) | (138,488)
Depreciable property, plant and equipment, net | 53,347 | 54,962
Construction-in-progress | 7,163 | 4,700
Property, plant and equipment, net | 60,510 | 59,662
Building and leasehold improvements |  |
Property, Plant and Equipment [Line Items] |  |
Depreciable property, plant and equipment at cost | 97,385 | 92,977
Laboratory equipment |  |
Property, Plant and Equipment [Line Items] |  |
Depreciable property, plant and equipment at cost | 42,704 | 40,121
Computer equipment and software |  |
Property, Plant and Equipment [Line Items] |  |
Depreciable property, plant and equipment at cost | 28,829 | 28,684
Manufacturing equipment |  |
Property, Plant and Equipment [Line Items] |  |
Depreciable property, plant and equipment at cost | 22,374 | 21,796
Furniture, fixtures, and other |  |
Property, Plant and Equipment [Line Items] |  |
Depreciable property, plant and equipment at cost | $ 10,094 | $ 9,872

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