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Income Taxes - Additional Information (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Income Taxes Disclosure [Line Items] |  |  |
Valuation allowance, increase (decrease) amount | $ (115,600) | $ 95,000 |
Income tax research credits | 4,727 | 3,081 | $ 10,511
Unrecognized tax benefits, interest recognized | 0 | 0 | 0
Unrecognized tax benefits, penalties recognized | $ 0 | $ 0 | $ 0
Unrecognized tax benefits, period may increase or decrease due to tax examination | 12 months |  |
Federal |  |  |
Income Taxes Disclosure [Line Items] |  |  |
Net operating loss carryforward for income tax | $ 2,400,000 |  |
Income tax research credits | 103,300 |  |
Federal orphan drug credits | 19,400 |  |
State |  |  |
Income Taxes Disclosure [Line Items] |  |  |
Net operating loss carryforward for income tax | 1,500,000 |  |
Income tax research credits | $ 47,000 |  |

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- Definition Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to research tax credit. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=121826272&loc=d3e32687-109319 + Details
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- Definition Amount of expense for penalties related to a tax position claimed or expected to be claimed in the tax return. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 15 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=121826272&loc=d3e32718-109319 + Details
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