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Selected Quarterly Financial Data | 12 Months Ended
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Dec. 31, 2021
Quarterly Financial Information Disclosure [Abstract] |
Selected Quarterly Financial Data | Selected Quarterly Financial Data (Unaudited) The following table sets forth certain unaudited quarterly financial data. In our opinion, the unaudited information set forth below has been prepared on the same basis as our audited information and includes all adjustments necessary to present fairly the information set forth herein. We have experienced fluctuations in our quarterly results and expect these fluctuations to continue in the future. Due to these and other factors, we believe that quarter-to-quarter comparisons of our operating results will not be meaningful, and the results for any one quarter may not be indicative of our future performance. All data is in thousands except per share information.
| Year Ended December 31, 2021 |  | Year Ended December 31, 2020
| Q1 |  | Q2 |  | Q3 |  | Q4 |  | Q1 |  | Q2 |  | Q3 |  | Q4
Product sales | $ | 4,795 |  |  | $ | 7,846 |  |  | $ | 5,194 |  |  | $ | 5,890 |  |  | $ | 3,444 |  |  | $ | 5,485 |  |  | $ | 5,691 |  |  | $ | 2,884 |
Total revenue | $ | 23,647 |  |  | $ | 28,330 |  |  | $ | 24,921 |  |  | $ | 25,009 |  |  | $ | 50,573 |  |  | $ | 48,847 |  |  | $ | 30,033 |  |  | $ | 23,462 |
Cost of goods sold | $ | 5,756 |  |  | $ | 7,667 |  |  | $ | 5,311 |  |  | $ | 6,163 |  |  | $ | 3,811 |  |  | $ | 5,773 |  |  | $ | 5,570 |  |  | $ | 4,323 |
Research and development expenses | $ | 95,604 |  |  | $ | 101,313 |  |  | $ | 103,738 |  |  | $ | 99,614 |  |  | $ | 108,987 |  |  | $ | 96,436 |  |  | $ | 100,531 |  |  | $ | 102,724 |
Operating loss | $ | (109,392) |  |  | $ | (110,205) |  |  | $ | (113,596) |  |  | $ | (112,910) |  |  | $ | (133,631) |  |  | $ | (77,709) |  |  | $ | (103,050) |  |  | $ | (110,721) |
Net loss | $ | (122,967) |  |  | $ | (125,519) |  |  | $ | (129,706) |  |  | $ | (145,645) |  |  | $ | (138,651) |  |  | $ | (80,000) |  |  | $ | (108,586) |  |  | $ | (117,203) |
Net loss per share, basic and diluted(1) | $ | (0.68) |  |  | $ | (0.69) |  |  | $ | (0.70) |  |  | $ | (0.79) |  |  | $ | (0.78) |  |  | $ | (0.45) |  |  | $ | (0.61) |  |  | $ | (0.65) |
_______________________________________________________________ (1)Quarterly loss per share amounts may not total to the year-to-date loss per share due to rounding.

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- Definition The entire disclosure for quarterly financial data. Includes, but is not limited to, tabular presentation of financial information for fiscal quarters, effect of year-end adjustments, and an explanation of matters or transactions that affect comparability of the information. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 270 -URI http://asc.fasb.org/topic&trid=2126967 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 270 -SubTopic 10 -Section 50 -Paragraph 1B -URI http://asc.fasb.org/extlink&oid=124502072&loc=SL124452896-108306 + Details
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