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Cash and Investments in Marketable Securities - Schedule of Cash and Investments in Marketable Securities, Including Cash Equivalents (Details) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020
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Estimated Fair Value at |  |
Cash and cash equivalents | $ 25,218 | $ 198,955
Short-term investments | 708,737 | 862,941
Long-term investments | 64,828 | 136,662
Total cash and investments in marketable securities | $ 798,783 | $ 1,198,558

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