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Organization and Summary of Significant Accounting Policies - Additional Information (Detail) - USD ($) |  | 3 Months Ended |
--- | --- | --- | ---
Apr. 25, 2022 | Mar. 31, 2022 | Mar. 31, 2021 | Dec. 31, 2021
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Cash and investments in marketable securities |  | $ 704,388,000 |  | $ 798,783,000
Accounts receivable |  | 30,220,000 |  | 22,492,000
Allowance for credit loss |  | 0 |  | 0
Revenue, excluding assessed tax |  | 24,822,000 | $ 23,647,000 |
Non-cash royalty revenue related to the sales of future royalties |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Revenue, excluding assessed tax |  | 17,561,000 | $ 18,798,000 |
Subsequent Event | Employee Severance |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Workforce termination, percentage | 70.00% |  |  |
Bristol Myers Squibb Collaboration Agreement |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |
Accounts receivable |  | $ 26,900,000 |  | $ 21,400,000

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