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Liabilities Related to Sales of Future Royalties - Activity Within the Liability Account (Details) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended | 126 Months Ended |
--- | --- | --- | --- | ---
Jun. 30, 2022 | Jun. 30, 2021 | Jun. 30, 2022 | Jun. 30, 2021 | Jun. 30, 2022 | Dec. 31, 2021
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Royalty monetization proceeds |  |  |  |  | $ 274,000 |
Non-cash royalty revenue |  |  | $ 33,825 | $ 39,254 | (367,277) |
Non-cash interest expense | $ 7,228 | $ 13,089 | 14,757 | $ 26,385 | 259,030 |
Payments to RPI |  |  |  |  | (10,000) |
Loss on revaluation of liability related to the sale of future royalties |  |  |  |  | 23,522 |
Liabilities related to the sales of future royalties – ending balance | 179,275 |  | 179,275 |  | 179,275 |
Less: unamortized transaction costs | (2,500) |  | (2,500) |  | (2,500) |
Liabilities related to the sales of future royalties, net | 176,775 |  | 176,775 |  | 176,775 | $ 195,427
2012 Purchase and Sale Agreement |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Royalty monetization proceeds |  |  |  |  | 124,000 |
Non-cash royalty revenue |  |  |  |  | (297,507) |
Non-cash interest expense |  |  |  |  | 229,474 |
Payments to RPI |  |  |  |  | (10,000) |
Loss on revaluation of liability related to the sale of future royalties |  |  |  |  | 23,522 |
Liabilities related to the sales of future royalties – ending balance | 69,489 |  | 69,489 |  | 69,489 |
Less: unamortized transaction costs | 0 |  | 0 |  | 0 |
Liabilities related to the sales of future royalties, net | 69,489 |  | 69,489 |  | 69,489 |
2020 Purchase and Sale Agreement |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Royalty monetization proceeds |  |  | 150,000 |  |  |
Non-cash royalty revenue |  |  | (69,770) |  |  |
Non-cash interest expense |  |  | 29,556 |  |  |
Payments to RPI |  |  | 0 |  |  |
Loss on revaluation of liability related to the sale of future royalties |  |  | 0 |  |  |
Liabilities related to the sales of future royalties – ending balance | 109,786 |  | 109,786 |  | 109,786 |
Less: unamortized transaction costs | (2,500) |  | (2,500) |  | (2,500) |
Liabilities related to the sales of future royalties, net | $ 107,286 |  | $ 107,286 |  | $ 107,286 |

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