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Stock-Based Compensation - Stock-Based Compensation Expense (Detail) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended
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Jun. 30, 2022 | Jun. 30, 2021 | Jun. 30, 2022 | Jun. 30, 2021
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |  |
Stock-based compensation | $ 11,103 | $ 23,714 | $ 32,064 | $ 47,612
Cost of goods sold |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |  |
Stock-based compensation | 649 | 716 | 1,317 | 1,443
Research and development |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |  |
Stock-based compensation | 4,751 | 13,479 | 16,793 | 27,641
General and administrative |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |  |
Stock-based compensation | 4,781 | 9,519 | 13,032 | 18,528
Restructuring, impairment and other costs of terminated program |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] |  |  |  |
Stock-based compensation | $ 922 | $ 0 | $ 922 | $ 0

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