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Organization and Summary of Significant Accounting Policies - Additional Information (Detail) - USD ($) | 1 Months Ended | 3 Months Ended | 6 Months Ended |
--- | --- | --- | --- | ---
Apr. 30, 2022 | Jun. 30, 2022 | Jun. 30, 2021 | Jun. 30, 2022 | Jun. 30, 2021 | Dec. 31, 2021
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |
Cash and investments in marketable securities |  | $ 628,244,000 |  | $ 628,244,000 |  | $ 798,783,000
Accounts receivable |  | 10,006,000 |  | 10,006,000 |  | 22,492,000
Accounts receivable, credit loss expense (reversal) |  | 0 | $ 0 | 0 | $ 0 |
Employee Severance |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |
Workforce termination, percentage | 70.00% |  |  |  |  |
Bristol Myers Squibb Collaboration Agreement |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |
Accounts receivable |  | $ 7,400,000 |  | $ 7,400,000 |  | $ 21,400,000

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