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Operating Leases - Additional Information (Details) $ in Thousands | 12 Months Ended
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Dec. 31, 2022 USD ($) ft² | Dec. 31, 2021 USD ($) | Dec. 31, 2020 USD ($)
Leases [Line Items] |  |  |
Impairment of right-of-use assets and property, plant and equipment | $ 65,761 | $ 0 | $ 0
Operating lease, payments | $ 20,100 | $ 16,800 | $ 16,200
Weighted average remaining lease term | 7 years 1 month 6 days |  |
Weighted average discount rate, percent | 5.80% |  |
Subleases aggregate lease payments | $ 10,500 |  |
Sublease Property, Plant And Equipment |  |  |
Leases [Line Items] |  |  |
Impairment of right-of-use assets and property, plant and equipment | $ 54,590 |  |
Mission Bay Facility |  |  |
Leases [Line Items] |  |  |
Lease space (in sq ft) | ft² | 155,215 |  |
Third Street Facility |  |  |
Leases [Line Items] |  |  |
Lease space (in sq ft) | ft² | 135,936 |  |

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- Definition Amount of cash outflow from operating lease, excluding payments to bring another asset to condition and location necessary for its intended use. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 842 -SubTopic 20 -Section 45 -Paragraph 5 -Subparagraph (c) -URI https://asc.fasb.org/extlink&oid=123391704&loc=SL77918643-209977 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 842 -SubTopic 20 -Section 50 -Paragraph 4 -Subparagraph (g)(1) -URI https://asc.fasb.org/extlink&oid=128292326&loc=SL77918686-209980 + Details
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- Definition Weighted average remaining lease term for operating lease, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days. + References Reference 1: http://www.xbrl.org/2003/role/exampleRef -Publisher FASB -Name Accounting Standards Codification -Topic 842 -SubTopic 20 -Section 55 -Paragraph 53 -URI https://asc.fasb.org/extlink&oid=123414884&loc=SL77918982-209971 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 842 -SubTopic 20 -Section 50 -Paragraph 4 -Subparagraph (g)(3) -URI https://asc.fasb.org/extlink&oid=128292326&loc=SL77918686-209980 + Details
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