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CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Revenue: |  |  |
Total revenue | $ 92,055 | $ 101,907 | $ 152,915
Operating costs and expenses: |  |  |
Cost of goods sold | 21,635 | 24,897 | 19,477
Research and development | 218,323 | 400,269 | 408,678
General and administrative | 92,333 | 122,844 | 104,682
Restructuring, impairment and other costs of terminated program | 135,930 | 0 | 45,189
Total operating costs and expenses | 468,221 | 548,010 | 578,026
Loss from operations | (376,166) | (446,103) | (425,111)
Non-operating income (expense): |  |  |
Change in fair value of development derivative liability | 33,427 | (8,023) | 0
Non-cash interest expense on liabilities related to the sales of future royalties | (28,911) | (47,313) | (30,267)
Loss on revaluation of liability related to the sale of future royalties | 0 | (24,410) | 0
Interest income and other income (expense), net | 6,667 | 2,569 | 18,282
Interest expense | 0 | 0 | (6,851)
Total non-operating income (expense), net | 11,183 | (77,177) | (18,836)
Loss before provision for income taxes | (364,983) | (523,280) | (443,947)
Provision for income taxes | 3,215 | 557 | 493
Net loss | $ (368,198) | $ (523,837) | $ (444,440)
Basic net loss per share (in dollars per share) | $ (1.97) | $ (2.86) | $ (2.49)
Diluted net loss per share (in dollars per share) | $ (1.97) | $ (2.86) | $ (2.49)
Weighted average shares outstanding used in computing basic net loss per share (in shares) | 187,138 | 183,298 | 178,581
Weighted average shares outstanding used in computing diluted net loss per share (in shares) | 187,138 | 183,298 | 178,581
Product sales |  |  |
Revenue: |  |  |
Total revenue | $ 20,348 | $ 23,725 | $ 17,504
Royalty revenue |  |  |
Revenue: |  |  |
Total revenue | 0 | 0 | 30,999
Non-cash royalty revenue related to the sales of future royalties |  |  |
Revenue: |  |  |
Total revenue | 69,794 | 77,746 | 48,563
License, collaboration and other revenue |  |  |
Revenue: |  |  |
Total revenue | $ 1,913 | $ 436 | $ 55,849

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