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Property, Plant and Equipment | 12 Months Ended
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Dec. 31, 2022
Property, Plant and Equipment [Abstract] |
Property, Plant and Equipment | Property, Plant and Equipment Property, plant and equipment consists of the following (in thousands):
| December 31,
| 2022 |  | 2021
Building and leasehold improvements | $ | 74,889 |  |  | $ | 97,385 |
Laboratory equipment | 24,243 |  |  | 42,704 |
Computer equipment and software | 26,205 |  |  | 28,829 |
Manufacturing equipment | 25,052 |  |  | 22,374 |
Furniture, fixtures, and other | 4,263 |  |  | 10,094 |
Depreciable property, plant and equipment at cost | 154,652 |  |  | 201,386 |
Less: accumulated depreciation | (124,731) |  |  | (148,039) |
Depreciable property, plant and equipment, net | 29,921 |  |  | 53,347 |
Construction-in-progress | 2,530 |  |  | 7,163 |
Property, plant and equipment, net | $ | 32,451 |  |  | $ | 60,510 |
Laboratory and manufacturing equipment, including construction-in-process, include assets that support both our manufacturing and research and development activities. Property, plant and equipment decreased significantly for the year ended December 31, 2022 as a result of our 2022 Restructuring Plan. As further disclosed in Note 11, we sold our research and development facility in India, we sold or disposed of laboratory equipment and certain computer software, and we recognized impairment charges for leasehold improvements and certain furniture and fixtures for spaces we seek to sublease. Depreciation and amortization expense for property, plant and equipment for the years ended December 31, 2022, 2021, and 2020 was $12.2 million, $13.0 million, and $12.5 million, respectively.

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- Definition The entire disclosure for long-lived, physical asset used in normal conduct of business and not intended for resale. Includes, but is not limited to, work of art, historical treasure, and similar asset classified as collections. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 958 -SubTopic 360 -Section 50 -Paragraph 6 -URI https://asc.fasb.org/extlink&oid=126982197&loc=d3e99893-112916 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 360 -URI https://asc.fasb.org/topic&trid=2155823 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 958 -SubTopic 360 -Section 50 -Paragraph 7 -URI https://asc.fasb.org/extlink&oid=126982197&loc=SL120174063-112916 Reference 4: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 958 -SubTopic 360 -Section 50 -Paragraph 1 -Subparagraph (d) -URI https://asc.fasb.org/extlink&oid=126982197&loc=d3e99779-112916 + Details
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