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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2022
Income Tax Disclosure [Abstract] |
Schedule of Income Before Income Tax, Domestic and Foreign | Loss before provision for income taxes includes the following components (in thousands):
| Year Ended December 31,
| 2022 |  | 2021 |  | 2020
Domestic | $ | (371,900) |  |  | $ | (524,440) |  |  | $ | (445,370) |
Foreign | 6,917 |  |  | 1,160 |  |  | 1,423 |
Loss before provision for income taxes | $ | (364,983) |  |  | $ | (523,280) |  |  | $ | (443,947) |
Schedule of Provision for Income Taxes | The provision for income taxes consists of the following (in thousands):
| Year Ended December 31,
| 2022 |  | 2021 |  | 2020
Current: |  |  |  |  |
Federal | $ | — |  |  | $ | — |  |  | $ | — |
State | (608) |  |  | 50 |  |  | 165 |
Foreign | 1,115 |  |  | 609 |  |  | 364 |
Total current income tax expense | 507 |  |  | 659 |  |  | 529 |
Deferred: |  |  |  |  |
Federal | — |  |  | — |  |  | — |
State | — |  |  | — |  |  | — |
Foreign | 2,708 |  |  | (102) |  |  | (36) |
Total deferred income tax expense | 2,708 |  |  | (102) |  |  | (36) |
Provision for income taxes | $ | 3,215 |  |  | $ | 557 |  |  | $ | 493 |
Schedule of Income Tax Provision Related to Continuing Operations | Our income tax provision related to continuing operations differs from the amount computed by applying the statutory income tax rate of 21% to our pretax loss as follows (in thousands):
| Year Ended December 31,
| 2022 |  | 2021 |  | 2020
Income tax benefit at federal statutory rate | $ | (76,647) |  |  | $ | (109,889) |  |  | $ | (93,229) |
Research credits | (987) |  |  | (4,727) |  |  | (3,081) |
Change in valuation allowance | 51,108 |  |  | 97,914 |  |  | 87,060 |
Expiration of net operating loss carryforwards | 12,348 |  |  | 286 |  |  | 286 |
Stock-based compensation | 15,778 |  |  | 6,627 |  |  | 7,929 |
Non-cash interest expense on liability related to sales of future royalties | 6,071 |  |  | 9,936 |  |  | 6,356 |
Non-cash royalty revenue related to sales of future royalties | (7,112) |  |  | (7,891) |  |  | (7,967) |
Loss on revaluation of liability related to the sale of future royalties | — |  |  | 4,940 |  |  | — |
Other | 2,656 |  |  | 3,361 |  |  | 3,139 |
Provision for income taxes | $ | 3,215 |  |  | $ | 557 |  |  | $ | 493 |
Schedule of Significant Components of Deferred Tax Assets and Liabilities | We measure deferred tax assets and liabilities based on the rates at which they are expected to reverse in the future. Significant components of our deferred tax assets for federal and state income taxes are as follows (in thousands):
| December 31,
| 2022 |  | 2021
Deferred tax assets: |  |  |
Net operating loss carryforwards | $ | 545,508 |  |  | $ | 564,712 |
Research and other credits | 142,198 |  |  | 139,996 |
Net capital loss carryforwards | 38,445 |  |  | — |
Operating lease liabilities | 28,254 |  |  | 34,680 |
Stock-based compensation | 22,110 |  |  | 33,408 |
Capitalized research and development costs | 24,134 |  |  | — |
Liability related to the sale of future royalties | 13,424 |  |  | 23,757 |
Other | 13,935 |  |  | 17,290 |
Deferred tax assets before valuation allowance | 828,008 |  |  | 813,843 |
Valuation allowance for deferred tax assets | (816,235) |  |  | (785,748) |
Total deferred tax assets | 11,773 |  |  | 28,095 |
Deferred tax liabilities: |  |  |
Operating lease right-of-use assets | (11,335) |  |  | (27,204) |
Investment in foreign subsidiary | (2,451) |  |  | — |
Other | (392) |  |  | (564) |
Total deferred tax liabilities | (14,178) |  |  | (27,768) |
Net deferred tax assets (liabilities) | $ | (2,405) |  |  | $ | 327 |
Schedule of Unrecognized Tax Benefits | We have the following activity relating to unrecognized tax benefits (in thousands):
| Year Ended December 31,
| 2022 |  | 2021 |  | 2020
Beginning balance | $ | 80,604 |  |  | $ | 78,665 |  |  | $ | 77,410 |
Tax positions related to current year: |  |  |  |  |
Additions | 378 |  |  | 2,371 |  |  | 2,512 |
Reductions | — |  |  | — |  |  | — |
Tax positions related to prior years: |  |  |  |  |
Additions | 5,272 |  |  | 58 |  |  | 193 |
Reductions | — |  |  | (490) |  |  | (1,450) |
Settlements | — |  |  | — |  |  | — |
Lapses in statute of limitations | (409) |  |  | — |  |  | — |
Ending balance | $ | 85,845 |  |  | $ | 80,604 |  |  | $ | 78,665 |

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