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Income Taxes - Schedule of Income Tax Provision Related to Continuing Operations (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Income Tax Disclosure [Abstract] |  |  |
Income tax benefit at federal statutory rate | $ (76,647) | $ (109,889) | $ (93,229)
Research credits | (987) | (4,727) | (3,081)
Change in valuation allowance | 51,108 | 97,914 | 87,060
Expiration of net operating loss carryforwards | 12,348 | 286 | 286
Stock-based compensation | 15,778 | 6,627 | 7,929
Non-cash interest expense on liability related to sales of future royalties | 6,071 | 9,936 | 6,356
Non-cash royalty revenue related to sales of future royalties | (7,112) | (7,891) | (7,967)
Loss on revaluation of liability related to the sale of future royalties | 0 | 4,940 | 0
Other | 2,656 | 3,361 | 3,139
Provision for income taxes | $ 3,215 | $ 557 | $ 493

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- Definition Effective Income Tax Rate Reconciliation, Non-cash Royalty Revenue Related To Sales Of Future Royalties, Amount + References No definition available. + Details
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- Definition Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to other nondeductible expenses. + References No definition available. + Details
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- Definition Amount of difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying domestic federal statutory income tax rate to pretax income (loss) from continuing operation, attributable to expense for award under share-based payment arrangement. Excludes expense determined to be nondeductible upon grant or after for award under share-based payment arrangement. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI https://asc.fasb.org/extlink&oid=121826272&loc=d3e32687-109319 Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 740 -Section 35 -Paragraph 2 -URI https://asc.fasb.org/extlink&oid=126970579&loc=d3e23163-113944 + Details
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