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Income Taxes - Schedule of Significant Components of Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2022 | Dec. 31, 2021
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Deferred tax assets: |  |
Net operating loss carryforwards | $ 545,508 | $ 564,712
Research and other credits | 142,198 | 139,996
Net capital loss carryforwards | 38,445 | 0
Operating lease liabilities | 28,254 | 34,680
Stock-based compensation | 22,110 | 33,408
Capitalized research and development costs | 24,134 | 0
Liability related to the sale of future royalties | 13,424 | 23,757
Other | 13,935 | 17,290
Deferred tax assets before valuation allowance | 828,008 | 813,843
Valuation allowance for deferred tax assets | (816,235) | (785,748)
Total deferred tax assets | 11,773 | 28,095
Deferred tax liabilities: |  |
Operating lease right-of-use assets | (11,335) | (27,204)
Investment in foreign subsidiary | (2,451) | 0
Other | (392) | (564)
Total deferred tax liabilities | (14,178) | (27,768)
Total deferred tax liabilities | $ (2,405) |
Net deferred tax assets (liabilities) |  | $ 327

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