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Property, Plant and Equipment - Schedule of Property, Plant and Equipment (Details) - USD ($) $ in Thousands | Dec. 31, 2022 | Dec. 31, 2021
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Property, Plant and Equipment [Line Items] |  |
Depreciable property, plant and equipment at cost | $ 154,652 | $ 201,386
Less: accumulated depreciation | (124,731) | (148,039)
Depreciable property, plant and equipment, net | 29,921 | 53,347
Construction-in-progress | 2,530 | 7,163
Property, plant and equipment, net | 32,451 | 60,510
Building and leasehold improvements |  |
Property, Plant and Equipment [Line Items] |  |
Depreciable property, plant and equipment at cost | 74,889 | 97,385
Laboratory equipment |  |
Property, Plant and Equipment [Line Items] |  |
Depreciable property, plant and equipment at cost | 24,243 | 42,704
Computer equipment and software |  |
Property, Plant and Equipment [Line Items] |  |
Depreciable property, plant and equipment at cost | 26,205 | 28,829
Manufacturing equipment |  |
Property, Plant and Equipment [Line Items] |  |
Depreciable property, plant and equipment at cost | 25,052 | 22,374
Furniture, fixtures, and other |  |
Property, Plant and Equipment [Line Items] |  |
Depreciable property, plant and equipment at cost | $ 4,263 | $ 10,094

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