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Liabilities Related to the Sales of Future Royalties (Tables) | 12 Months Ended
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Dec. 31, 2022
Liability Related To Sale Of Potential Future Royalties [Abstract] |
Schedule of Liability Related to Potential Future Royalties | The following table shows the activity within the liability account of each arrangement (in thousands):
| Year-Ended December 31, 2022 |  | Period from inception to December 31, 2022
| 2012 Purchase and Sale Agreement |  | 2020 Purchase and Sale Agreement |  | Total |  | 2012 Purchase and Sale Agreement |  | 2020 Purchase and Sale Agreement |  | Total
Liabilities related to the sales of future royalties—beginning balance | $ | 78,282 |  |  | $ | 120,062 |  |  | $ | 198,344 |  |  | $ | — |  |  | $ | — |  |  | $ | — |
Royalty monetization proceeds | — |  |  | — |  |  | — |  |  | 124,000 |  |  | 150,000 |  |  | 274,000 |
Non-cash royalty revenue | (33,865) |  |  | (35,929) |  |  | (69,794) |  |  | (316,523) |  |  | (86,722) |  |  | (403,245) |
Non-cash interest expense | 10,750 |  |  | 18,161 |  |  | 28,911 |  |  | 234,168 |  |  | 39,016 |  |  | 273,184 |
Payments to RPI | — |  |  | — |  |  | — |  |  | (10,000) |  |  | — |  |  | (10,000) |
Loss on revaluation of liability related to the sale of future royalties | — |  |  |  |  | — |  |  | 23,522 |  |  | — |  |  | 23,522 |
Liabilities related to the sales of future royalties – ending balance | 55,167 |  |  | 102,294 |  |  | 157,461 |  |  | 55,167 |  |  | 102,294 |  |  | 157,461 |
Less: unamortized transaction costs | — |  |  | (2,083) |  |  | (2,083) |  |  | — |  |  | (2,083) |  |  | (2,083) |
Liabilities related to the sales of future royalties, net | $ | 55,167 |  |  | $ | 100,211 |  |  | $ | 155,378 |  |  | $ | 55,167 |  |  | $ | 100,211 |  |  | $ | 155,378 |

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