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Organization and Summary of Significant Accounting Policies (Details) shares in Millions |  |  | 1 Months Ended | 3 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | --- | ---
Jan. 14, 2020 USD ($) | Jul. 23, 2017 | Apr. 30, 2022 | Sep. 30, 2022 USD ($) | Dec. 31, 2022 USD ($) reporting_unit shares | Dec. 31, 2021 USD ($) shares | Dec. 31, 2020 USD ($) shares | Mar. 31, 2022 USD ($)
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |
Cash and investments in marketable securities |  |  |  |  | $ 504,977,000 | $ 798,783,000 |  |
Net expense reimbursements from collaboration partner |  |  |  |  |  | 21,400,000 |  |
Number of reporting unit evaluated for goodwill | reporting_unit |  |  |  |  | 1 |  |  |
Total revenue |  |  |  |  | $ 92,055,000 | 101,907,000 | $ 152,915,000 |
Level 3 | Development Derivative Liability |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |
Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value |  |  |  |  | $ 0 | $ 27,726,000 | $ 0 | $ 0
Employee Severance |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |
Percent of positions eliminated |  |  | 70.00% |  |  |  |  |
Expense recognized during the period |  |  |  | $ 30,904,000 |  |  |  |
Stock Options, RSUs and PSUs |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |
Weighted average antidilutive securities excluded from computation of earnings per share (in shares) | shares |  |  |  |  | 21.2 | 18.4 | 17.4 |
BMS Collaboration Agreement |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |
Sales milestone revenue |  |  |  |  |  | $ 50,000,000 |  |
Nektar-358 | Nektar's | Eli Lilly And Company |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |
Percentage of regulatory milestones payments will be reduced if conditions occur |  | 75.00% |  |  |  |  |  |
Cash And NonCash Royalties |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |
Total revenue |  |  |  |  | $ 69,800,000 | $ 77,700,000 | $ 79,600,000 |
NKTR - 181 | Program Termination |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |
Expense recognized during the period | $ 45,200,000 |  |  |  |  |  |  |
NKTR - 181 | Program Termination, Advance Paymnt To Contract Manyfacturers |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |
Expense recognized during the period | 19,700,000 |  |  |  |  |  |  |
NKTR - 181 | Program Termination, Noncancellable Commitments |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |
Expense recognized during the period | $ 25,500,000 |  |  |  |  |  |  |
Buildings |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |
Property and equipment estimated useful lives |  |  |  |  | 20 years |  |  |
Minimum | Manufacturing equipment |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |
Property and equipment estimated useful lives |  |  |  |  | 3 years |  |  |
Maximum | Nektar-358 | Nektar's | Eli Lilly And Company |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |
Percentage of funding phase 3 development costs on an indication by indication basis borne |  | 25.00% |  |  |  |  |  |
Maximum | Manufacturing equipment |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |
Property and equipment estimated useful lives |  |  |  |  | 10 years |  |  |

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