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Stockholders' Equity - Additional Information (Details) - USD ($) | Apr. 03, 2018 | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
--- | --- | --- | --- | --- | ---
Class of Stock [Line Items] |  |  |  |  |
Stock issued during period subject to lock-up and stand-still provisions period | 5 years |  |  |  |
Aggregate offering price |  | $ 300,000,000 |  |  |
Losses recorded in AOCI |  | (366,638,000) | $ (679,508,000) | $ (1,077,295,000) | $ (1,405,391,000)
Common Stock |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |
Sale of stock to Bristol-Myers Squibb (in shares) | 8,284,600 |  |  |  |
Losses recorded in AOCI |  | (19,000) | $ (19,000) | $ (18,000) | $ (17,000)
AOCI, Accumulated Gain (Loss), Debt Securities, Available-for-Sale, Parent |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |
Losses recorded in AOCI |  | 1,800,000 |  |  |
Accumulated Foreign Currency Adjustment Attributable to Parent |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |
Losses recorded in AOCI |  | $ 5,100,000 |  |  |

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