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v3.23.1

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2023 | Mar. 31, 2022
Cash flows from operating activities: |  |
Net loss | $ (137,018) | $ (90,393)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Non-cash royalty revenue related to the sales of future royalties | (16,861) | (17,561)
Non-cash interest expense | 6,405 | 7,529
Change in fair value of development derivative liability | 0 | (33,427)
Non-cash research and development expense | 0 | 4,951
Stock-based compensation | 10,019 | 20,961
Depreciation and amortization | 2,302 | 3,730
Deferred income tax expense | (1,812) | 0
Impairment of other property, plant and equipment | 13,200 | 0
Impairment of goodwill | 76,501 | 0
Amortization of premiums (discounts), net and other non-cash transactions | (3,129) | 1,276
Changes in operating assets and liabilities: |  |
Accounts receivable | 2,986 | (7,728)
Inventory | (1,033) | 422
Operating leases, net | (1,786) | 1,787
Other assets | 5,591 | 2,864
Accounts payable | (8,920) | 2,998
Accrued expenses | 1,640 | 14,167
Net cash used in operating activities | (51,915) | (88,424)
Cash flows from investing activities: |  |
Purchases of investments | (107,012) | (93,493)
Maturities of investments | 148,043 | 227,974
Purchases of property, plant and equipment | (433) | (4,203)
Net cash provided by investing activities | 40,598 | 130,278
Cash flows from financing activities: |  |
Proceeds from shares issued under equity compensation plans | 0 | 188
Cash receipts from development derivative liability | 0 | 750
Net cash provided by financing activities | 0 | 938
Effect of foreign exchange rates on cash and cash equivalents | 45 | (17)
Net increase (decrease) in cash and cash equivalents | (11,272) | 42,775
Cash and cash equivalents at beginning of period | 88,227 | 25,218
Cash and cash equivalents at end of period | $ 76,955 | $ 67,993

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