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v3.23.1

Condensed Consolidated Financial Statement Details (Tables) | 3 Months Ended
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Mar. 31, 2023
Inventory Disclosure [Abstract] |
Schedule of Inventory | Inventory consists of the following (in thousands):
| March 31, 2023 |  | December 31, 2022
Raw materials | $ | 2,234 |  |  | $ | 2,575 |
Work-in-process | 13,167 |  |  | 10,749 |
Finished goods | 4,834 |  |  | 5,878 |
Total inventory | $ | 20,235 |  |  | $ | 19,202 |
Schedule of Property, Plant and Equipment | Property, plant and equipment consists of the following (in thousands):
| March 31, 2023 |  | December 31, 2022
Building and leasehold improvements | $ | 69,137 |  |  | $ | 74,889 |
Computer equipment and computer software | 24,894 |  |  | 26,205 |
Manufacturing equipment | 25,339 |  |  | 25,052 |
Laboratory equipment | 13,566 |  |  | 24,243 |
Furniture, fixtures and other | 3,990 |  |  | 4,263 |
Depreciable property, plant and equipment at cost | 136,926 |  |  | 154,652 |
Less: accumulated depreciation | (110,653) |  |  | (124,731) |
Depreciable property, plant and equipment, net | 26,273 |  |  | 29,921 |
Construction in process | 811 |  |  | 2,530 |
Property, plant and equipment, net | $ | 27,084 |  |  | $ | 32,451 |
Schedule of Goodwill | The following is a reconciliation of the changes in our goodwill for the three months ended March 31, 2023 (in thousands):
|  | Three months ended March 31, 2023
Goodwill – beginning balance |  | $ | 76,501 |
Impairment of goodwill |  | (76,501) |
Goodwill – ending balance |  | $ | — |
Schedule of Liability Related to Sale of Potential Future Royalties | The following is a reconciliation of the changes in our liabilities related to the sales of future royalties for the three months ended March 31, 2023 (in thousands):
| Three Months Ended March 31, 2023
| 2012 Purchase and Sale Agreement |  | 2020 Purchase and Sale Agreement |  | Total
Liabilities related to the sales of future royalties, net – beginning balance | $ | 55,167 |  |  | $ | 100,211 |  |  | $ | 155,378 |
Non-cash royalty revenue | (9,303) |  |  | (7,558) |  |  | (16,861) |
Non-cash interest expense | 1,360 |  |  | 5,045 |  |  | 6,405 |
Amortization of transaction costs | — |  |  | 209 |  |  | 209 |
Liabilities related to the sales of future royalties, net – ending balance | $ | 47,224 |  |  | $ | 97,907 |  |  | $ | 145,131 |
Schedule of Accrued Expenses | Accrued Expenses Accrued expenses consist of the following (in thousands):
| March 31, 2023 |  | December 31, 2022
Accrued compensation | $ | 14,888 |  |  | $ | 9,582 |
Accrued clinical trial expenses | 7,739 |  |  | 12,262 |
Liability to collaboration partners | 3,495 |  |  | 3,808 |
Accrued contract termination costs | 3,461 |  |  | 3,902 |
Other accrued expenses | 7,827 |  |  | 7,003 |
Total accrued expenses | $ | 37,410 |  |  | $ | 36,557 |

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