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v3.23.2

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2023 | Jun. 30, 2022
Cash flows from operating activities: |  |
Net loss | $ (188,140) | $ (249,461)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Non-cash royalty revenue related to the sales of future royalties | (32,693) | (33,825)
Non-cash interest expense on liabilities related to the sales of future royalties | 12,557 | 14,757
Change in fair value of development derivative liability | 0 | (33,427)
Non-cash research and development expense | 0 | 4,951
Stock-based compensation | 17,985 | 32,064
Depreciation and amortization | 4,468 | 7,171
Deferred income tax expense | (1,839) | 0
Impairment of right-of-use assets and property, plant and equipment | 26,455 | 57,321
Impairment of goodwill | 76,501 | 0
Amortization of premiums (discounts), net and other non-cash transactions | (8,150) | 700
Changes in operating assets and liabilities: |  |
Accounts receivable | 4,646 | 12,486
Inventory | (1,487) | (1,168)
Operating leases, net | (3,717) | 1,486
Other assets | 7,902 | 7,627
Accounts payable | (9,997) | 2,833
Accrued expenses | (7,929) | 13,068
Net cash used in operating activities | (103,438) | (163,417)
Cash flows from investing activities: |  |
Purchases of investments | (249,724) | (247,014)
Maturities of investments | 316,088 | 466,423
Purchases of property, plant and equipment | (595) | (4,983)
Net cash provided by investing activities | 65,769 | 214,426
Cash flows from financing activities: |  |
Proceeds from shares issued under equity compensation plans | 18 | 655
Cash receipts from development derivative liability | 0 | 750
Net cash provided by financing activities | 18 | 1,405
Effect of foreign exchange rates on cash and cash equivalents | 152 | (87)
Net increase (decrease) in cash and cash equivalents | (37,499) | 52,327
Cash and cash equivalents at beginning of period | 88,227 | 25,218
Cash and cash equivalents at end of period | 50,728 | 77,545
Supplemental disclosures of cash flow information: |  |
Cash paid for income taxes | $ 2,656 | $ 85

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