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Condensed Consolidated Financial Statement Details (Tables) | 6 Months Ended
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Jun. 30, 2023
Inventory Disclosure [Abstract] |
Schedule of Inventory | Inventory consists of the following (in thousands):
| June 30, 2023 |  | December 31, 2022
Raw materials | $ | 2,045 |  |  | $ | 2,575 |
Work-in-process | 12,879 |  |  | 10,749 |
Finished goods | 5,765 |  |  | 5,878 |
Total inventory | $ | 20,689 |  |  | $ | 19,202 |
Schedule of Other Current Assets | Other current assets consist of the following (in thousands):
| June 30, 2023 |  | December 31, 2022
Prepaid research and development expenses | $ | 3,265 |  |  | $ | 7,398 |
Other prepaid expenses | 3,804 |  |  | 5,987 |
Non-trade receivables and other | 2,533 |  |  | 2,423 |
Total other current assets | $ | 9,602 |  |  | $ | 15,808 |
Schedule of Property, Plant and Equipment | Property, plant and equipment consists of the following (in thousands):
| June 30, 2023 |  | December 31, 2022
Building and leasehold improvements | $ | 62,526 |  |  | $ | 74,889 |
Computer equipment and computer software | 24,623 |  |  | 26,205 |
Manufacturing equipment | 25,404 |  |  | 25,052 |
Laboratory equipment | 13,109 |  |  | 24,243 |
Furniture, fixtures and other | 4,068 |  |  | 4,263 |
Depreciable property, plant and equipment at cost | 129,730 |  |  | 154,652 |
Less: accumulated depreciation | (107,637) |  |  | (124,731) |
Depreciable property, plant and equipment, net | 22,093 |  |  | 29,921 |
Construction in process | 461 |  |  | 2,530 |
Property, plant and equipment, net | $ | 22,554 |  |  | $ | 32,451 |
Schedule of Goodwill | The following is a reconciliation of the changes in our goodwill for the six months ended June 30, 2023 (in thousands):
|  | Six months ended June 30, 2023
Goodwill – beginning balance |  | $ | 76,501 |
Impairment of goodwill |  | (76,501) |
Goodwill – ending balance |  | $ | — |
Schedule of Accrued Expenses | Accrued Expenses Accrued expenses consist of the following (in thousands):
| June 30, 2023 |  | December 31, 2022
Accrued compensation | $ | 10,670 |  |  | $ | 9,582 |
Accrued clinical trial expenses | 5,517 |  |  | 12,262 |
Liability to collaboration partners | 4,472 |  |  | 3,808 |
Accrued contract termination costs | 3,084 |  |  | 3,902 |
Other accrued expenses | 5,399 |  |  | 7,003 |
Total accrued expenses | $ | 29,142 |  |  | $ | 36,557 |
Schedule of Liability Related to Sale of Potential Future Royalties | The following is a reconciliation of the changes in our liabilities related to the sales of future royalties for the six months ended June 30, 2023 (in thousands):
| Six Months Ended June 30, 2023
| 2012 Purchase and Sale Agreement |  | 2020 Purchase and Sale Agreement |  | Total
Liabilities related to the sales of future royalties, net – beginning balance | $ | 55,167 |  |  | $ | 100,211 |  |  | $ | 155,378 |
Non-cash royalty revenue | (17,496) |  |  | (15,197) |  |  | (32,693) |
Non-cash interest expense | 2,538 |  |  | 10,019 |  |  | 12,557 |
Amortization of transaction costs | — |  |  | 417 |  |  | 417 |
Liabilities related to the sales of future royalties, net – ending balance | $ | 40,209 |  |  | $ | 95,450 |  |  | $ | 135,659 |
Schedule of Accumulated Other Comprehensive Income (Loss) | The following table summarizes the changes in accumulated other comprehensive income (loss) by component (in thousands):
| Foreign currency translation |  |  | Available-for-sale securities |  |  | Accumulated Other Comprehensive Income
Balance at December 31, 2022 | $ | (5,131) |  |  |  | $ | (1,776) |  |  |  | $ | (6,907) |
Foreign currency translation adjustments | 139 |  |  |  | — |  |  |  | 139 |
Unrealized gain on available-for-sale securities | — |  |  |  | 1,087 |  |  |  | 1,087 |
Balance at March 31, 2023 | $ | (4,992) |  |  |  | $ | (689) |  |  |  | $ | (5,681) |
Foreign currency translation adjustments | 13 |  |  |  | — |  |  |  | 13 |
Unrealized gain on available-for-sale securities | — |  |  |  | 244 |  |  |  | 244 |
Reclassification adjustments to income | (1,026) |  |  |  | — |  |  |  | (1,026) |
Balance at June 30, 2023 | $ | (6,005) |  |  |  | $ | (445) |  |  |  | $ | (6,450) |

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