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Restructuring, Impairment and Costs of Terminated Program - Sublease Information (Details) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Restructuring Cost and Reserve [Line Items] |  |  |
Book value in excess of fair value | $ 36,962 | $ 67,875 |
Less: Amounts recorded as amortization for Third St. facility and Mission Bay facility | (1,634) | (2,114) |
Total impairment of sublease assets |  | 65,761 |
Total impairment of right-of-use assets and property, plant and equipment | 35,328 | 65,761 | $ 0
Reported Value Measurement |  |  |
Restructuring Cost and Reserve [Line Items] |  |  |
Property, plant and equipment and operating lease right-of-use assets | 53,498 | 88,829 |
Property, Plant and Equipment |  |  |
Restructuring Cost and Reserve [Line Items] |  |  |
Book value in excess of fair value | 5,034 | 11,568 |
Less: Amounts recorded as amortization for Third St. facility and Mission Bay facility | (263) | (397) |
Total impairment of sublease assets | 30,600 | 11,171 |
Total impairment of right-of-use assets and property, plant and equipment | 4,771 |  |
Property, Plant and Equipment | Reported Value Measurement |  |  |
Restructuring Cost and Reserve [Line Items] |  |  |
Property, plant and equipment and operating lease right-of-use assets | 7,206 | 16,348 |
Operating Lease Right-of-Use Assets |  |  |
Restructuring Cost and Reserve [Line Items] |  |  |
Book value in excess of fair value | 31,928 | 56,307 |
Less: Amounts recorded as amortization for Third St. facility and Mission Bay facility | (1,371) | (1,717) |
Total impairment of sublease assets |  | 54,590 |
Total impairment of right-of-use assets and property, plant and equipment | 30,557 |  |
Operating Lease Right-of-Use Assets | Reported Value Measurement |  |  |
Restructuring Cost and Reserve [Line Items] |  |  |
Property, plant and equipment and operating lease right-of-use assets | 46,292 | 72,481 |
Level 3 | Estimate of Fair Value Measurement |  |  |
Restructuring Cost and Reserve [Line Items] |  |  |
Property, plant and equipment and operating lease right-of-use assets | (16,536) | (20,954) |
Level 3 | Property, Plant and Equipment | Estimate of Fair Value Measurement |  |  |
Restructuring Cost and Reserve [Line Items] |  |  |
Property, plant and equipment and operating lease right-of-use assets | (2,172) | (4,780) |
Level 3 | Operating Lease Right-of-Use Assets | Estimate of Fair Value Measurement |  |  |
Restructuring Cost and Reserve [Line Items] |  |  |
Property, plant and equipment and operating lease right-of-use assets | $ (14,364) | $ (16,174) |

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