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Income Taxes - Schedule of Significant Components of Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2023 | Dec. 31, 2022
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Deferred tax assets: |  |
Net operating loss carryforwards | $ 574,737 | $ 545,508
Research and other credits | 144,128 | 142,198
Net capital loss carryforwards | 39,655 | 38,445
Operating lease liabilities | 25,384 | 28,254
Stock-based compensation | 19,447 | 22,110
Capitalized research and development costs | 34,675 | 24,134
Liability related to the sale of future royalties | 6,729 | 13,424
Other | 13,863 | 13,935
Deferred tax assets before valuation allowance | 858,618 | 828,008
Valuation allowance for deferred tax assets | (854,528) | (816,235)
Total deferred tax assets | 4,090 | 11,773
Deferred tax liabilities: |  |
Operating lease right-of-use assets | (3,824) | (11,335)
Investment in foreign subsidiary | (521) | (2,451)
Other | (265) | (392)
Total deferred tax liabilities | (4,610) | (14,178)
Total deferred tax liabilities | $ (520) | $ (2,405)

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