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Organization and Summary of Significant Accounting Policies - Additional Information (Detail) - USD ($) |  |  | 1 Months Ended | 3 Months Ended |
--- | --- | --- | --- | --- | ---
Mar. 04, 2024 | Feb. 12, 2024 | Mar. 31, 2024 | Jun. 30, 2023 | Apr. 30, 2022 | Mar. 31, 2024 | Mar. 31, 2023 | Dec. 31, 2023
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |
Cash and investments in marketable securities |  |  | $ 326,016,000 |  |  | $ 326,016,000 |  | $ 329,441,000
Proceeds from issuance of pre-funded warrant |  |  |  |  |  | 30,000,000 | $ 0 |
Accounts receivable, credit loss expense (reversal) |  |  |  |  |  | $ 0 | $ 0 |
Bristol Myers Squibb Company |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |
Sale of stock repurchased cash consideration |  | $ 3,000,000 |  |  |  |  |  |
Sale of stock shares repurchased |  | 8,300,000 |  |  |  |  |  |
Securities Purchase Agreement | TCG Crossover Fund II, L.P. |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |
Proceeds from issuance of pre-funded warrant | $ 30,000,000 |  | $ 30,000,000 |  |  |  |  |
2020 Purchase and Sale Agreement |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |
Amount exchanged to remove cap on royalties | $ 15,000,000 |  |  |  |  |  |  |
Pre-Funded Warrant | Securities Purchase Agreement | TCG Crossover Fund II, L.P. |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |
Number of warrants issued to be purchase common shares | 25,000,000 |  | 25,000,000 |  |  | 25,000,000 |  |
Shares issued, price per share | $ 1.2 |  | $ 1.2 |  |  | $ 1.2 |  |
Employee Severance | 2022 Restructuring Plan |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |
Workforce termination, percentage |  |  |  |  | 70.00% |  |  |
Employee Severance | 2023 Restructuring Plan |  |  |  |  |  |  |  |
Organization And Summary Of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |
Workforce termination, percentage |  |  |  | 60.00% |  |  |  |

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