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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2024 | Mar. 31, 2023
Cash flows from operating activities: |  |
Net loss | $ (36,802) | $ (137,018)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Non-cash royalty revenue related to the sales of future royalties | (15,508) | (16,861)
Non-cash interest expense on liabilities related to the sales of future royalties | 5,531 | 6,405
Stock-based compensation | 6,000 | 10,019
Depreciation and amortization | 1,607 | 2,302
Deferred income tax expense | (38) | (1,812)
Impairment of right-of-use assets and property, plant and equipment | 0 | 13,200
Impairment of goodwill | 0 | 76,501
Provision for net realizable value of inventory | 1,006 | 952
Amortization of premiums (discounts), net and other non-cash transactions | (3,063) | (3,129)
Changes in operating assets and liabilities: |  |
Accounts receivable | (2,412) | 2,986
Inventory | (1,143) | (1,985)
Operating leases, net | (2,958) | (1,786)
Other assets | (976) | 5,591
Accounts payable | (988) | (8,920)
Accrued expenses | 1,856 | 1,640
Net cash used in operating activities | (47,888) | (51,915)
Cash flows from investing activities: |  |
Purchases of investments | (105,059) | (107,012)
Maturities of investments | 124,474 | 148,043
Purchases of property, plant and equipment | (157) | (433)
Net cash provided by investing activities | 19,258 | 40,598
Cash flows from financing activities: |  |
Proceeds from shares issued under equity compensation plans | 3 | 0
Proceeds from issuance of pre-funded warrant | 30,000 | 0
Proceeds from sale of future royalties | 15,000 | 0
Repurchase of common stock from Bristol-Myers Squibb | (3,000) | 0
Net cash provided by financing activities | 42,003 | 0
Effect of foreign exchange rates on cash and cash equivalents | (8) | 45
Net increase (decrease) in cash and cash equivalents | 13,365 | (11,272)
Cash and cash equivalents at beginning of period | 35,277 | 88,227
Cash and cash equivalents at end of period | $ 48,642 | $ 76,955

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