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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2024 | Jun. 30, 2023
Cash flows from operating activities: |  |
Net loss | $ (89,165) | $ (188,140)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Non-cash royalty revenue related to the sales of future royalties | (32,298) | (32,693)
Non-cash interest expense on liabilities related to the sales of future royalties | 11,939 | 12,557
Stock-based compensation | 11,418 | 17,985
Depreciation and amortization | 3,066 | 4,468
Deferred income tax expense | 19 | (1,839)
Impairment of right-of-use assets and property, plant and equipment | 8,329 | 26,455
Impairment of goodwill | 0 | 76,501
Provision for net realizable value of inventory | 2,567 | 1,252
Amortization of premiums (discounts), net and other non-cash transactions | (5,647) | (8,150)
Changes in operating assets and liabilities: |  |
Accounts receivable | 9 | 4,646
Inventory | (931) | (2,739)
Operating leases, net | (4,196) | (3,717)
Other assets | 1,817 | 7,902
Accounts payable | (3,266) | (9,997)
Accrued expenses | 10,749 | (7,929)
Net cash used in operating activities | (85,590) | (103,438)
Cash flows from investing activities: |  |
Purchases of investments | (173,504) | (249,724)
Maturities of investments | 210,087 | 316,088
Purchases of property, plant and equipment | (343) | (595)
Net cash provided by investing activities | 36,240 | 65,769
Cash flows from financing activities: |  |
Proceeds from shares issued under equity compensation plans | 22 | 18
Proceeds from issuance of pre-funded warrant | 30,000 | 0
Proceeds from sale of future royalties | 15,000 | 0
Repurchase of common stock from Bristol-Myers Squibb | (3,000) | 0
Net cash provided by financing activities | 42,022 | 18
Effect of foreign exchange rates on cash and cash equivalents | (9) | 152
Net increase (decrease) in cash and cash equivalents | (7,337) | (37,499)
Cash and cash equivalents at beginning of period | 35,277 | 88,227
Cash and cash equivalents at end of period | $ 27,940 | $ 50,728

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