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CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY - USD ($) shares in Thousands, $ in Thousands | Total | Common Shares | Treasury Stock | Capital in Excess of Par Value | Accumulated Other Comprehensive Income (Loss) | Accumulated Deficit
--- | --- | --- | --- | --- | --- | ---
Beginning balance (in shares) at Dec. 31, 2022 |  | 188,560 |  |  |  |
Beginning balance at Dec. 31, 2022 | $ 366,638 | $ 19 |  | $ 3,574,719 | $ (6,907) | $ (3,201,193)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Shares issued under equity compensation plans (in shares) |  | 675 |  |  |  |
Stock-based compensation | 10,019 |  |  | 10,019 |  |
Comprehensive income (loss) | (135,792) |  |  |  | 1,226 | (137,018)
Ending balance (in shares) at Mar. 31, 2023 |  | 189,235 |  |  |  |
Ending balance at Mar. 31, 2023 | 240,865 | $ 19 |  | 3,584,738 | (5,681) | (3,338,211)
Beginning balance (in shares) at Dec. 31, 2022 |  | 188,560 |  |  |  |
Beginning balance at Dec. 31, 2022 | 366,638 | $ 19 |  | 3,574,719 | (6,907) | (3,201,193)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Comprehensive income (loss) | (187,683) |  |  |  |  |
Ending balance (in shares) at Jun. 30, 2023 |  | 190,119 |  |  |  |
Ending balance at Jun. 30, 2023 | 196,958 | $ 19 |  | 3,592,722 | (6,450) | (3,389,333)
Beginning balance (in shares) at Mar. 31, 2023 |  | 189,235 |  |  |  |
Beginning balance at Mar. 31, 2023 | 240,865 | $ 19 |  | 3,584,738 | (5,681) | (3,338,211)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Shares issued under equity compensation plans (in shares) |  | 884 |  |  |  |
Shares issued under equity compensation plans | 18 |  |  | 18 |  |
Stock-based compensation | 7,966 |  |  | 7,966 |  |
Comprehensive income (loss) | (51,891) |  |  |  | (769) | (51,122)
Ending balance (in shares) at Jun. 30, 2023 |  | 190,119 |  |  |  |
Ending balance at Jun. 30, 2023 | $ 196,958 | $ 19 |  | 3,592,722 | (6,450) | (3,389,333)
Beginning balance (in shares) at Dec. 31, 2023 | 191,384 | 191,384 |  |  |  |
Beginning balance at Dec. 31, 2023 | $ 130,987 | $ 19 |  | 3,608,137 | 80 | (3,477,249)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Shares issued under equity compensation plans (in shares) |  | 525 |  |  |  |
Shares issued under equity compensation plans | 3 |  |  | 3 |  |
Stock-based compensation | 6,000 |  |  | 6,000 |  |
Repurchase of common stock from Bristol-Myers Squibb (in shares) |  | (8,285) | 8,285 |  |  |
Repurchase of common stock from Bristol-Myers Squibb | (3,000) |  | $ (3,000) |  |  |
Issuance of prefunded warrant | 30,000 |  |  | 30,000 |  |
Comprehensive income (loss) | (37,285) |  |  |  | (483) | (36,802)
Ending balance (in shares) at Mar. 31, 2024 |  | 183,624 | 8,285 |  |  |
Ending balance at Mar. 31, 2024 | $ 126,705 | $ 19 | $ (3,000) | 3,644,140 | (403) | (3,514,051)
Beginning balance (in shares) at Dec. 31, 2023 | 191,384 | 191,384 |  |  |  |
Beginning balance at Dec. 31, 2023 | $ 130,987 | $ 19 |  | 3,608,137 | 80 | (3,477,249)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Comprehensive income (loss) | $ (89,739) |  |  |  |  |
Ending balance (in shares) at Jun. 30, 2024 | 184,061 | 184,061 | 8,285 |  |  |
Ending balance at Jun. 30, 2024 | $ 79,688 | $ 19 | $ (3,000) | 3,649,577 | (494) | (3,566,414)
Beginning balance (in shares) at Mar. 31, 2024 |  | 183,624 | 8,285 |  |  |
Beginning balance at Mar. 31, 2024 | 126,705 | $ 19 | $ (3,000) | 3,644,140 | (403) | (3,514,051)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |
Shares issued under equity compensation plans (in shares) |  | 437 |  |  |  |
Shares issued under equity compensation plans | 19 |  |  | 19 |  |
Stock-based compensation | 5,418 |  |  | 5,418 |  |
Comprehensive income (loss) | $ (52,454) |  |  |  | (91) | (52,363)
Ending balance (in shares) at Jun. 30, 2024 | 184,061 | 184,061 | 8,285 |  |  |
Ending balance at Jun. 30, 2024 | $ 79,688 | $ 19 | $ (3,000) | $ 3,649,577 | $ (494) | $ (3,566,414)

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