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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2024 | Sep. 30, 2023
Cash flows from operating activities: |  |
Net loss | $ (126,222) | $ (233,977)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Non-cash royalty revenue related to the sales of future royalties | (48,029) | (50,860)
Non-cash interest expense on liabilities related to the sales of future royalties | 17,959 | 18,467
Stock-based compensation | 16,809 | 26,134
Depreciation and amortization | 4,059 | 6,163
Deferred income tax expense | (12) | (1,854)
Impairment of right-of-use assets and property, plant and equipment | 8,329 | 36,628
Impairment of goodwill | 0 | 76,501
Provision for net realizable value of inventory | 20 | 4,444
Amortization of premiums (discounts), net and other non-cash transactions | (7,711) | (12,137)
Changes in operating assets and liabilities: |  |
Accounts receivable | (841) | 3,777
Inventory | (808) | (372)
Operating leases, net | (7,620) | (6,078)
Other assets | (1,761) | 4,450
Accounts payable | (1,023) | (9,328)
Accrued expenses | 17,329 | (7,517)
Net cash used in operating activities | (129,522) | (145,559)
Cash flows from investing activities: |  |
Purchases of investments | (191,882) | (372,821)
Maturities of investments | 275,247 | 494,385
Purchases of property, plant and equipment | (1,009) | (628)
Sale of property, plant and equipment |  | 1,245
Net cash provided by investing activities | 82,356 | 122,181
Cash flows from financing activities: |  |
Proceeds from shares issued under equity compensation plans | 35 | 18
Proceeds from issuance of pre-funded warrant | 30,000 | 0
Proceeds from sale of future royalties | 15,000 | 0
Repurchase of common stock from Bristol-Myers Squibb | (3,000) | 0
Net cash provided by financing activities | 42,035 | 18
Effect of foreign exchange rates on cash and cash equivalents | (37) | 54
Net increase (decrease) in cash and cash equivalents | (5,168) | (23,306)
Cash and cash equivalents at beginning of period | 35,277 | 88,227
Cash and cash equivalents at end of period | $ 30,109 | 64,921
Supplemental disclosure of cash flow information: |  |
Cash paid for income taxes |  | $ 2,656

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