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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 3 Months Ended | 12 Months Ended | 154 Months Ended
--- | --- | --- | ---
Mar. 31, 2023 | Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2024
Cash flows from operating activities: |  |  |  |
Net loss |  | $ (118,961) | $ (276,056) |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |
Non-cash royalty revenue related to the sales of future royalties |  | (64,267) | (68,921) | $ (536,433)
Non-cash interest expense on liabilities related to sales of future royalties |  | 28,112 | 25,334 | 326,630
Stock-based compensation |  | 21,612 | 33,388 |
Depreciation and amortization |  | 4,391 | 7,815 |
Impairment of right-of-use assets and property, plant and equipment |  | 8,329 | 35,328 |
Impairment of goodwill | $ 76,500 | 0 | 76,501 |
Gain on sale of the Huntsville manufacturing facility |  | (40,390) | 0 |
(Gain) loss on sale or disposal of property, plant and equipment, net |  | 0 | 1,300 |
Provision for net realizable value of inventory |  | 949 | 2,402 |
Foreign currency translation adjustment |  | 0 | 5,099 |
Amortization of premiums (discounts), net |  | (9,245) | (14,856) |
Changes in operating assets and liabilities: |  |  |  |
Accounts receivable |  | (3,045) | 4,776 |
Inventory |  | 497 | 699 |
Operating leases, net |  | (12,905) | (8,850) |
Other assets |  | (4,187) | 3,583 |
Accounts payable |  | 2,668 | (2,884) |
Accrued expenses |  | 10,733 | (17,264) |
Net cash used in operating activities |  | (175,709) | (192,606) |
Cash flows from investing activities: |  |  |  |
Purchases of investments |  | (261,709) | (511,699) |
Maturities of investments |  | 340,361 | 650,883 |
Proceeds from sale of the Huntsville manufacturing facility, net |  | 65,386 | 0 |
Sales of investments |  | 0 | 0 |
Purchases of property, plant and equipment |  | (1,468) | (865) |
Sales of property, plant and equipment |  | 0 | 1,245 |
Net cash provided by investing activities |  | 142,570 | 139,564 |
Cash flows from financing activities: |  |  |  |
Proceeds from shares issued under equity compensation plans |  | 118 | 30 |
Proceeds from issuance of pre-funded warrant |  | 30,000 | 0 |
Proceeds from sale of future royalties |  | 15,000 | 0 |
Repurchase of common stock from Bristol-Myers Squibb |  | (3,000) | 0 |
Net cash provided by financing activities |  | 42,118 | 30 |
Effect of foreign exchange rates on cash and cash equivalents |  | (4) | 62 |
Net increase (decrease) in cash and cash equivalents |  | 8,975 | (52,950) |
Cash and cash equivalents at beginning of year | $ 88,227 | 35,277 | 88,227 |
Cash and cash equivalents at end of year |  | 44,252 | 35,277 | $ 44,252
Non-cash investing and financing activities: |  |  |  |
Fair value of equity method investment in Gannet BioChem received in exchange for sale of Huntsville manufacturing facility |  | 12,218 | 0 |
Transaction costs and net working capital adjustment for sale of Huntsville manufacturing facility included in accounts payable and accrued expenses |  | 697 | 0 |
Supplemental disclosure of cash flow information: |  |  |  |
Cash paid for income taxes |  | $ 76 | $ 2,656 |

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