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v3.25.0.1

Segment Reporting - Summary of Significant Expense Categories and Consolidated Net Loss (Details) - USD ($) $ in Thousands | 12 Months Ended | 154 Months Ended
--- | --- | ---
Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2024
Segment Reporting Information [Line Items] |  |  |
Revenue | $ 98,427 | $ 90,122 |
Operating costs and expenses: |  |  |
Cost of goods sold | 30,686 | 33,768 |
Clinical development, contract manufacturing and other third party costs | 76,850 | 57,249 |
Employee costs | 40,204 | 55,572 |
Facilities costs | 16,821 | 20,832 |
Other operating costs | 42,047 | 37,048 |
Other segment expenses | 37,407 | 149,337 |
Gain on sale of the Huntsville manufacturing facility | (40,390) |  |
Total operating costs and expenses | 203,625 | 353,806 |
Loss from operations | (105,198) | (263,684) |
Non-operating income (expense): |  |  |
Non-cash interest expense on liabilities related to the sales of future royalties | (28,112) | (25,334) | $ (326,630)
Interest income | 14,500 | 19,009 |
Other income (expense), net | (390) | (6,247) |
Total non-operating income (expense), net | (14,002) | (12,572) |
Loss before provision for income taxes | (119,200) | (276,256) |
Rezpegaldesleukin (cytokine Treg stimulant) |  |  |
Operating costs and expenses: |  |  |
Clinical development, contract manufacturing and other third party costs | 49,382 | 14,554 |
NKTR-255 (IL-15 receptor agonist) |  |  |
Operating costs and expenses: |  |  |
Clinical development, contract manufacturing and other third party costs | 15,795 | 26,132 |
NKTR-0165 (tumor necrosis factor receptor type II agonist) |  |  |
Operating costs and expenses: |  |  |
Clinical development, contract manufacturing and other third party costs | 9,339 | 9,345 |
Discovery Research and Other Programs |  |  |
Operating costs and expenses: |  |  |
Clinical development, contract manufacturing and other third party costs | $ 2,334 | $ 7,218 |

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