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Liabilities Related to the Sales of Future Royalties - Schedule of Liability Related to Potential Future Royalties (Detail) - USD ($)
$ in Thousands
 12 Months Ended 48 Months Ended 154 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2024
Dec. 31, 2024
Liability Related To Sale Of Future Royalties [Roll Forward]        
Liabilities related to the sales of future royalties—beginning balance $ 113,874     $ 0
Royalty monetization proceeds 15,000     289,000
Non-cash royalty revenue (64,267) $ (68,921)   (536,433)
Non-cash interest expense 28,112 25,334   326,630
Payments to RPI 0     (10,000)
Loss on revaluation of liability related to the sale of future royalties 0     23,522
Liabilities related to the sales of future royalties – ending balance 92,719 113,874 $ 92,719 92,719
Less: unamortized transaction costs (943)   (943) (943)
Liabilities related to the sales of future royalties, net 91,776 112,625 91,776 91,776
2012 Purchase and Sale Agreement        
Liability Related To Sale Of Future Royalties [Roll Forward]        
Liabilities related to the sales of future royalties—beginning balance 24,217     0
Royalty monetization proceeds 0     124,000
Non-cash royalty revenue (26,881)     (380,728)
Non-cash interest expense 9,861     250,403
Payments to RPI 0     (10,000)
Loss on revaluation of liability related to the sale of future royalties 0     23,522
Liabilities related to the sales of future royalties – ending balance 7,197 24,217 7,197 7,197
Less: unamortized transaction costs 0   0 0
Liabilities related to the sales of future royalties, net 7,197   7,197 7,197
2020 Purchase and Sale Agreement        
Liability Related To Sale Of Future Royalties [Roll Forward]        
Liabilities related to the sales of future royalties—beginning balance 89,657   0  
Royalty monetization proceeds 15,000   165,000  
Non-cash royalty revenue (37,386)   (155,705)  
Non-cash interest expense 18,251   76,227  
Payments to RPI 0   0  
Loss on revaluation of liability related to the sale of future royalties 0   0  
Liabilities related to the sales of future royalties – ending balance 85,522 $ 89,657 85,522 85,522
Less: unamortized transaction costs (943)   (943) (943)
Liabilities related to the sales of future royalties, net $ 84,579   $ 84,579 $ 84,579