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v3.25.2

Segment Reporting - Summary of Significant Expense Categories and Consolidated Net Loss (Details) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2025 | Jun. 30, 2024 | Jun. 30, 2025 | Jun. 30, 2024
Segment Reporting Information [Line Items] |  |  |  |  |  |
Revenue | $ 11,175 | $ 23,489 | [1] | $ 21,635 | $ 45,128 | [1]
Operating costs and expenses: |  |  |  |  |  |
Cost of goods sold | 0 | 9,740 | [1] | 0 | 18,274 | [1]
Clinical development, contract manufacturing and other third party costs | 19,079 | 19,301 |  | 37,021 | 34,756 |
Employee costs | 10,920 | 10,054 |  | 22,894 | 20,371 |
Facilities costs | 2,968 | 4,106 |  | 6,326 | 8,638 |
Other operating costs | 10,324 | 11,224 |  | 27,584 | 22,429 |
Other segment expenses | 4,114 | 18,838 |  | 8,575 | 25,861 |
Total operating costs and expenses | 47,405 | 73,263 | [1] | 102,400 | 130,329 | [1]
Loss from operations | (36,230) | (49,774) | [1] | (80,765) | (85,201) | [1]
Non-operating income (expense): |  |  |  |  |  |
Non-cash interest expense on liabilities related to the sales of future royalties | (5,394) | (6,408) | [1] | (10,368) | (11,939) | [1]
Interest income | 1,969 | 3,901 | [1] | 4,843 | 8,121 | [1]
Other income (expense), net | 260 | (36) | [1] | 526 | (135) | [1]
Total non-operating income (expense), net | (3,165) | (2,543) | [1] | (4,999) | (3,953) | [1]
Loss before provision (benefit) for income taxes and equity method investment | (39,395) | (52,317) | [1] | (85,764) | (89,154) | [1]
Provision (benefit) for income taxes | (188) | 46 | [1] | (136) | 11 | [1]
Loss before equity method investment | (39,207) | (52,363) | [1] | (85,628) | (89,165) | [1]
Loss from equity method investment | (2,386) | 0 | [1] | (6,847) | 0 | [1]
Net loss | (41,593) | (52,363) | [1] | (92,475) | (89,165) | [1]
Rezpegaldesleukin (cytokine Treg stimulant) |  |  |  |  |  |
Operating costs and expenses: |  |  |  |  |  |
Clinical development, contract manufacturing and other third party costs | 12,930 | 12,099 |  | 26,733 | 20,983 |
NKTR-255 (IL-15 receptor agonist) |  |  |  |  |  |
Operating costs and expenses: |  |  |  |  |  |
Clinical development, contract manufacturing and other third party costs | 2,232 | 4,196 |  | 3,621 | 7,682 |
NKTR-0165 (tumor necrosis factor receptor type II agonist) |  |  |  |  |  |
Operating costs and expenses: |  |  |  |  |  |
Clinical development, contract manufacturing and other third party costs | 3,531 | 1,833 |  | 5,812 | 3,851 |
Discovery Research and Other Programs |  |  |  |  |  |
Operating costs and expenses: |  |  |  |  |  |
Clinical development, contract manufacturing and other third party costs | $ 386 | $ 1,173 |  | $ 855 | $ 2,240 |
[1] | All share and per share amounts have been retrospectively adjusted to reflect a one-for-fifteen reverse stock split (see Note 6).

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