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CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (DEFICIT) - USD ($) $ in Thousands | Total | Secondary Offering | At-the-Market Offering | Common Shares | Common Shares Secondary Offering | Common Shares At-the-Market Offering | Treasury Stock | Treasury Stock Secondary Offering | Capital in Excess of Par Value | Capital in Excess of Par Value Secondary Offering | [2] | Capital in Excess of Par Value At-the-Market Offering | [2] | Accumulated Other Comprehensive Income/(Loss) | Accumulated Deficit
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Beginning balance (in shares) at Dec. 31, 2023 | [1] |  |  |  |  | 12,757,984 |  |  |  |  |  |  |  |  |  |  |  |  |
Beginning balance at Dec. 31, 2023 |  | $ 130,987 |  |  |  | $ 1 | [1] |  |  |  |  |  |  | $ 3,608,155 | [1] |  |  | $ 80 | $ (3,477,249)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued under equity compensation plans (in shares) | [1] |  |  |  |  | 35,131 |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued under equity compensation plans |  | 3 |  |  |  |  |  |  |  |  |  |  |  | 3 | [1] |  |  |  |
Stock-based compensation |  | 6,000 |  |  |  |  |  |  |  |  |  |  |  | 6,000 | [1] |  |  |  |
Repurchase of common stock from Bristol-Myers Squibb (in shares) | [1] |  |  |  |  | (552,307) |  |  |  |  | 552,307 |  |  |  |  |  |  |  |
Repurchase of common stock from Bristol-Myers Squibb |  | (3,000) |  |  |  |  |  |  |  |  | $ (3,000) |  |  |  |  |  |  |  |
Issuance of prefunded warrant |  | 30,000 |  |  |  |  |  |  |  |  |  |  |  | 30,000 | [1] |  |  |  |
Comprehensive income (loss) |  | (37,285) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (483) | (36,802)
Ending balance (in shares) at Mar. 31, 2024 | [1] |  |  |  |  | 12,240,808 |  |  |  |  |  |  |  |  |  |  |  |  |
Ending balance at Mar. 31, 2024 |  | 126,705 |  |  |  | $ 1 | [1] |  |  |  | $ (3,000) |  |  | 3,644,158 | [1] |  |  | (403) | (3,514,051)
Ending balance (in shares) at Mar. 31, 2024 | [1] |  |  |  |  |  |  |  |  |  | 552,307 |  |  |  |  |  |  |  |
Beginning balance (in shares) at Dec. 31, 2023 | [1] |  |  |  |  | 12,757,984 |  |  |  |  |  |  |  |  |  |  |  |  |
Beginning balance at Dec. 31, 2023 |  | 130,987 |  |  |  | $ 1 | [1] |  |  |  |  |  |  | 3,608,155 | [1] |  |  | 80 | (3,477,249)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Comprehensive income (loss) |  | (125,947) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending balance (in shares) at Sep. 30, 2024 | [1] |  |  |  |  | 12,296,312 |  |  |  |  |  |  |  |  |  |  |  |  |
Ending balance at Sep. 30, 2024 |  | 48,884 |  |  |  | $ 1 | [1] |  |  |  | $ (3,000) |  |  | 3,654,999 | [1] |  |  | 355 | (3,603,471)
Ending balance (in shares) at Sep. 30, 2024 | [1] |  |  |  |  |  |  |  |  |  | 552,307 |  |  |  |  |  |  |  |
Beginning balance (in shares) at Mar. 31, 2024 | [1] |  |  |  |  | 12,240,808 |  |  |  |  |  |  |  |  |  |  |  |  |
Beginning balance at Mar. 31, 2024 |  | 126,705 |  |  |  | $ 1 | [1] |  |  |  | $ (3,000) |  |  | 3,644,158 | [1] |  |  | (403) | (3,514,051)
Beginning balance (in shares) at Mar. 31, 2024 | [1] |  |  |  |  |  |  |  |  |  | 552,307 |  |  |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued under equity compensation plans (in shares) | [1] |  |  |  |  | 29,095 |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued under equity compensation plans |  | 19 |  |  |  |  |  |  |  |  |  |  |  | 19 | [1] |  |  |  |
Stock-based compensation |  | 5,418 |  |  |  |  |  |  |  |  |  |  |  | 5,418 | [1] |  |  |  |
Comprehensive income (loss) |  | (52,454) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (91) | (52,363)
Ending balance (in shares) at Jun. 30, 2024 | [1] |  |  |  |  | 12,269,903 |  |  |  |  |  |  |  |  |  |  |  |  |
Ending balance at Jun. 30, 2024 |  | 79,688 |  |  |  | $ 1 | [1] |  |  |  | $ (3,000) |  |  | 3,649,595 | [1] |  |  | (494) | (3,566,414)
Ending balance (in shares) at Jun. 30, 2024 | [1] |  |  |  |  |  |  |  |  |  | 552,307 |  |  |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued under equity compensation plans (in shares) | [1] |  |  |  |  | 26,409 |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued under equity compensation plans |  | 13 |  |  |  |  |  |  |  |  |  |  |  | 13 | [1] |  |  |  |
Stock-based compensation |  | 5,391 |  |  |  |  |  |  |  |  |  |  |  | 5,391 | [1] |  |  |  |
Comprehensive income (loss) |  | (36,208) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 849 | (37,057)
Ending balance (in shares) at Sep. 30, 2024 | [1] |  |  |  |  | 12,296,312 |  |  |  |  |  |  |  |  |  |  |  |  |
Ending balance at Sep. 30, 2024 |  | $ 48,884 |  |  |  | $ 1 | [1] |  |  |  | $ (3,000) |  |  | 3,654,999 | [1] |  |  | 355 | (3,603,471)
Ending balance (in shares) at Sep. 30, 2024 | [1] |  |  |  |  |  |  |  |  |  | 552,307 |  |  |  |  |  |  |  |
Beginning balance (in shares) at Dec. 31, 2024 |  | 12,385,001 |  |  |  | 12,385,001 | [2] |  |  |  |  |  |  |  |  |  |  |  |
Beginning balance at Dec. 31, 2024 |  | $ 60,737 | [3] |  |  | $ 1 | [2] |  |  |  | $ (3,000) |  |  | 3,659,885 | [2] |  |  | 61 | (3,596,210)
Beginning balance (in shares) at Dec. 31, 2024 |  | 552,307 |  |  |  |  |  |  |  |  | 552,307 | [2] |  |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued under equity compensation plans (in shares) | [2] |  |  |  |  | 21,709 |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued under equity compensation plans |  | $ 7 |  |  |  |  |  |  |  |  |  |  |  | 7 | [2] |  |  |  |
Stock-based compensation |  | 3,898 |  |  |  |  |  |  |  |  |  |  |  | 3,898 | [2] |  |  |  |
Comprehensive income (loss) |  | (50,904) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (22) | (50,882)
Ending balance (in shares) at Mar. 31, 2025 | [2] |  |  |  |  | 12,406,710 |  |  |  |  |  |  |  |  |  |  |  |  |
Ending balance at Mar. 31, 2025 |  | $ 13,738 |  |  |  | $ 1 | [2] |  |  |  | $ (3,000) |  |  | 3,663,790 | [2] |  |  | 39 | (3,647,092)
Ending balance (in shares) at Mar. 31, 2025 | [2] |  |  |  |  |  |  |  |  |  | 552,307 |  |  |  |  |  |  |  |
Beginning balance (in shares) at Dec. 31, 2024 |  | 12,385,001 |  |  |  | 12,385,001 | [2] |  |  |  |  |  |  |  |  |  |  |  |
Beginning balance at Dec. 31, 2024 |  | $ 60,737 | [3] |  |  | $ 1 | [2] |  |  |  | $ (3,000) |  |  | 3,659,885 | [2] |  |  | 61 | (3,596,210)
Beginning balance (in shares) at Dec. 31, 2024 |  | 552,307 |  |  |  |  |  |  |  |  | 552,307 | [2] |  |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Comprehensive income (loss) |  | $ (128,002) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Ending balance (in shares) at Sep. 30, 2025 |  | 19,652,513 |  |  |  | 19,652,513 | [2] |  |  |  |  |  |  |  |  |  |  |  |
Ending balance at Sep. 30, 2025 |  | $ 85,086 |  |  |  | $ 2 | [2] |  |  |  |  |  |  | 3,809,235 | [2] |  |  | 56 | (3,724,207)
Ending balance (in shares) at Sep. 30, 2025 |  | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Beginning balance (in shares) at Mar. 31, 2025 | [2] |  |  |  |  | 12,406,710 |  |  |  |  |  |  |  |  |  |  |  |  |
Beginning balance at Mar. 31, 2025 |  | $ 13,738 |  |  |  | $ 1 | [2] |  |  |  | $ (3,000) |  |  | 3,663,790 | [2] |  |  | 39 | (3,647,092)
Beginning balance (in shares) at Mar. 31, 2025 | [2] |  |  |  |  |  |  |  |  |  | 552,307 |  |  |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued under equity compensation plans (in shares) | [2] |  |  |  |  | 50,542 |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued under equity compensation plans |  | 211 |  |  |  |  |  |  |  |  |  |  |  | 211 | [2] |  |  |  |
Stock-based compensation |  | 3,486 |  |  |  |  |  |  |  |  |  |  |  | 3,486 | [2] |  |  |  |
Comprehensive income (loss) |  | (41,646) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (53) | (41,593)
Ending balance (in shares) at Jun. 30, 2025 | [2] |  |  |  |  | 12,457,252 |  |  |  |  |  |  |  |  |  |  |  |  |
Ending balance at Jun. 30, 2025 |  | (24,211) |  |  |  | $ 1 | [2] |  |  |  | $ (3,000) |  |  | 3,667,487 | [2] |  |  | (14) | (3,688,685)
Ending balance (in shares) at Jun. 30, 2025 | [2] |  |  |  |  |  |  |  |  |  | 552,307 |  |  |  |  |  |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued under equity compensation plans (in shares) | [2] |  |  |  |  | 34,778 |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued under equity compensation plans |  | 236 |  |  |  |  |  |  |  |  |  |  |  | 236 | [2] |  |  |  |
Stock-based compensation |  | 3,072 |  |  |  |  |  |  |  |  |  |  |  | 3,072 | [2] |  |  |  |
Shares issued under offering, net of underwriting discounts and offering costs (in shares) | [2] |  |  |  |  |  |  | 4,893,618 |  | 600,198 |  |  | (552,307) |  |  |  |  |  |
Shares issued under offering, net of underwriting discounts and offering costs |  |  |  | $ 107,160 | $ 34,279 |  |  | $ 1 | [2] |  |  |  | $ 3,000 |  |  | $ 104,159 | $ 34,279 |  |
Shares issued under prefunded warrant exercise (in shares) | [2] |  |  |  |  | 1,666,667 |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of prefunded warrant |  | 2 |  |  |  |  |  |  |  |  |  |  |  | 2 | [2] |  |  |  |
Comprehensive income (loss) |  | $ (35,452) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 70 | (35,522)
Ending balance (in shares) at Sep. 30, 2025 |  | 19,652,513 |  |  |  | 19,652,513 | [2] |  |  |  |  |  |  |  |  |  |  |  |
Ending balance at Sep. 30, 2025 |  | $ 85,086 |  |  |  | $ 2 | [2] |  |  |  |  |  |  | $ 3,809,235 | [2] |  |  | $ 56 | $ (3,724,207)
Ending balance (in shares) at Sep. 30, 2025 |  | 0 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
[1] | All share amounts have been retrospectively adjusted to reflect a one-for-fifteen reverse stock split (see Note 6).
[2] | All share amounts have been retrospectively adjusted to reflect a one-for-fifteen reverse stock split (see Note 6).
[3] | All share and per share amounts have been retrospectively adjusted to reflect a one-for-fifteen reverse stock split (see Note 6).

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