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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2025 | Sep. 30, 2024
Cash flows from operating activities: |  |  |
Net loss | $ (127,997) | $ (126,222) |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Non-cash royalty revenue related to the sales of future royalties | (33,125) | (48,029) |
Non-cash interest expense on liabilities related to the sales of future royalties | 16,415 | 17,959 | [1]
Loss from equity method investment | 7,381 | 0 | [1]
Stock-based compensation | 10,456 | 16,809 |
Depreciation and amortization expense | 836 | 4,059 |
Impairment of right-of-use assets and property and equipment | 0 | 8,329 |
Provision for net realizable value of inventory | 0 | 20 |
Amortization of premiums (discounts), net | (3,626) | (7,711) |
Changes in operating assets and liabilities: |  |  |
Accounts receivable | 0 | (841) |
Inventory | 0 | (808) |
Operating leases, net | (9,407) | (7,620) |
Other assets | (5,591) | (1,761) |
Accounts payable | 4,168 | (1,023) |
Accrued expenses | (3,062) | 17,317 |
Net cash used in operating activities | (143,552) | (129,522) |
Cash flows from investing activities: |  |  |
Purchases of investments | (193,410) | (191,882) |
Maturities of investments | 192,691 | 275,247 |
Purchases of property and equipment | (153) | (1,009) |
Payment of transaction costs and working capital adjustment from the sale of the Huntsville manufacturing facility | (697) | 0 |
Net cash provided by (used in) investing activities | (1,569) | 82,356 |
Cash flows from financing activities: |  |  |
Proceeds from shares issued under equity compensation plans and other | 456 | 35 |
Payments of offering costs associated with issuance of common stock | (1,150) | 0 |
Proceeds from issuance of pre-funded warrant | 0 | 30,000 |
Proceeds from sale of future royalties | 0 | 15,000 |
Repurchase of common stock from Bristol-Myers Squibb | 0 | (3,000) |
Net cash provided by financing activities | 141,895 | 42,035 |
Effect of foreign exchange rates on cash and cash equivalents | 6 | (37) |
Net decrease in cash and cash equivalents | (3,220) | (5,168) |
Cash and cash equivalents at beginning of period | 44,252 | 35,277 |
Cash and cash equivalents at end of period | 41,032 | 30,109 |
2025 Secondary Public Offering |  |  |
Cash flows from financing activities: |  |  |
Proceeds from offering, net | 108,100 | 0 |
At-the-Market Offering |  |  |
Cash flows from financing activities: |  |  |
Proceeds from offering, net | $ 34,489 | $ 0 |
[1] | All share and per share amounts have been retrospectively adjusted to reflect a one-for-fifteen reverse stock split (see Note 6).

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