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Pay vs Performance Disclosure - USD ($) | 12 Months Ended
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Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Pay vs Performance Disclosure |  |  |  |  |
Pay vs Performance Disclosure, Table | PAY VERSUS PERFORMANCE In accordance with rules adopted by the Securities and Exchange Commission pursuant to the Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010, we provide the following disclosure regarding executive compensation for our principal executive officer (“PEO”) and Non-PEO NEOs and Company performance for the fiscal years listed below. The Compensation Committee did not consider the pay versus performance disclosure below in making its pay decisions for any of the years shown.
| Year |  |  | Summary Compensation Table Total for PEO1 ($) |  |  | Compensation Actually Paid to PEO1, 2, 3 ($) |  |  | Average Summary Compensation Table Total for Non-PEO NEOs1 ($) |  |  | Average Compensation Actually Paid to Non-PEO NEOs1,2,3 ($) |  |  | Value of Initial Fixed $100 Investment based on:4 |  |  | Net Income ($ Millions) |
| TSR ($) |  |  | Peer Group TSR ($) |
| 2024 |  |  | 3,762,693 |  |  | 5,354,245 |  |  | 1,123,266 |  |  | 1,427,279 |  |  | 4.31 |  |  | 118.20 |  |  | (119) |
| 2023 |  |  | 3,135,576 |  |  | (773,200) |  |  | 1,122,330 |  |  | (2,644) |  |  | 2.62 |  |  | 118.87 |  |  | (276) |
| 2022 |  |  | 11,275,830 |  |  | (8,738,814) |  |  | 3,091,330 |  |  | (3,426,582) |  |  | 10.47 |  |  | 113.65 |  |  | (368) |
| 2021 |  |  | 11,153,616 |  |  | 8,032,023 |  |  | 4,377,734 |  |  | 3,290,039 |  |  | 62.59 |  |  | 126.45 |  |  | (524) |
| 2020 |  |  | 11,241,149 |  |  | 6,456,336 |  |  | 4,379,031 |  |  | 2,020,372 |  |  | 78.76 |  |  | 126.42 |  |  | (444) |
1. | Howard Robin was our PEO for each year presented. The individuals comprising the Non-PEO NEOs for each year presented are listed below.
| 2020-2021 |  |  | 2022 |  |  | 2023 |  |  | 2024 |
| Gil M. Labrucherie |  |  | Gil M. Labrucherie |  |  | Jillian B. Thomsen |  |  | Sandra Gardiner |
| Mark A. Wilson |  |  | Jillian Thomsen |  |  | Sandra Gardiner |  |  | Mark A. Wilson |
| Jonathan Zalevsky |  |  | Mark A. Wilson |  |  | Mark A. Wilson |  |  | Jonathan Zalevsky |
| John Northcott |  |  | Jonathan Zalevsky |  |  | Jonathan Zalevsky |  |  |  |
|  |  |  | John Northcott |  |  |  |  |  |  |
2. | The amounts shown for Compensation Actually Paid have been calculated in accordance with Item 402(v) of Regulation S-K and do not reflect compensation actually earned, realized, or received by the Company’s NEOs. These amounts reflect the Summary Compensation Table Total with certain adjustments as described in footnote 3 below.
3. | Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEO and the Non-PEO NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Exclusion of Stock Awards column are the totals from the Stock Awards column set forth in the Summary Compensation Table.
| Year |  |  | Summary Compensation Table Total for PEO ($) |  |  | Exclusion of Stock Awards for PEO ($) |  |  | Inclusion of Equity Values for PEO ($) |  |  | Compensation Actually Paid to PEO ($) |
| 2024 |  |  | 3,762,693 |  |  | (1,596,122) |  |  | 3,187,674 |  |  | 5,354,245 |
| Year |  |  | Average Summary Compensation Table Total for Non-PEO NEOs ($) |  |  | Average Exclusion of Stock Awards for Non-PEO NEOs ($) |  |  | Average Inclusion of Equity Values for Non-PEO NEOs ($) |  |  | Average Compensation Actually Paid to Non-PEO NEOs ($) |
| 2024 |  |  | 1,123,266 |  |  | (286,483) |  |  | 590,496 |  |  | 1,427,279 |
The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables:
| Year |  |  | Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for First PEO ($) |  |  | Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for First PEO ($) |  |  | Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year for First PEO ($) |  |  | Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for First PEO ($) |  |  | Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for First PEO ($) |  |  | Total - Inclusion of Equity Values for First PEO ($) |
| 2024 |  |  | 1,495,265 |  |  | 917,377 |  |  | 0 |  |  | 775,032 |  |  | 0 |  |  | 3,187,674 |
| Year |  |  | Average Year- End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for Non- PEO NEOs ($) |  |  | Average Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for Non-PEO NEOs ($) |  |  | Average Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year for Non- PEO NEOs ($) |  |  | Average Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for Non-PEO NEOs ($) |  |  | Average Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for Non-PEO NEOs ($) |  |  | Total - Average Inclusion of Equity Values for Non-PEO NEOs ($) |
| 2024 |  |  | 271,086 |  |  | 153,951 |  |  | 0 |  |  | 165,459 |  |  | 0 |  |  | 590,496 |
4. | The Peer Group TSR set forth in this table utilizes the NASDAQ Biotechnology Index, which we also utilize in the stock performance graph required by Item 201(e) of Regulation S-K included in our Form 10-K for the year ended December 31, 2024. The comparison assumes $100 was invested for the period starting December 31, 2019, through the end of the listed year in the Company and in the NASDAQ Biotechnology Index, respectively. Historical stock performance is not necessarily indicative of future stock performance.
Named Executive Officers, Footnote |
1. | Howard Robin was our PEO for each year presented. The individuals comprising the Non-PEO NEOs for each year presented are listed below.
| 2020-2021 |  |  | 2022 |  |  | 2023 |  |  | 2024 |
| Gil M. Labrucherie |  |  | Gil M. Labrucherie |  |  | Jillian B. Thomsen |  |  | Sandra Gardiner |
| Mark A. Wilson |  |  | Jillian Thomsen |  |  | Sandra Gardiner |  |  | Mark A. Wilson |
| Jonathan Zalevsky |  |  | Mark A. Wilson |  |  | Mark A. Wilson |  |  | Jonathan Zalevsky |
| John Northcott |  |  | Jonathan Zalevsky |  |  | Jonathan Zalevsky |  |  |  |
|  |  |  | John Northcott |  |  |  |  |  |  |
Peer Group Issuers, Footnote |
4. | The Peer Group TSR set forth in this table utilizes the NASDAQ Biotechnology Index, which we also utilize in the stock performance graph required by Item 201(e) of Regulation S-K included in our Form 10-K for the year ended December 31, 2024. The comparison assumes $100 was invested for the period starting December 31, 2019, through the end of the listed year in the Company and in the NASDAQ Biotechnology Index, respectively. Historical stock performance is not necessarily indicative of future stock performance.
PEO Total Compensation Amount | $ 3,762,693 | $ 3,135,576 | $ 11,275,830 | $ 11,153,616 | $ 11,241,149
PEO Actually Paid Compensation Amount | $ 5,354,245 | (773,200) | (8,738,814) | 8,032,023 | 6,456,336
Adjustment To PEO Compensation, Footnote |
3. | Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEO and the Non-PEO NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Exclusion of Stock Awards column are the totals from the Stock Awards column set forth in the Summary Compensation Table.
| Year |  |  | Summary Compensation Table Total for PEO ($) |  |  | Exclusion of Stock Awards for PEO ($) |  |  | Inclusion of Equity Values for PEO ($) |  |  | Compensation Actually Paid to PEO ($) |
| 2024 |  |  | 3,762,693 |  |  | (1,596,122) |  |  | 3,187,674 |  |  | 5,354,245 |
The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables:
| Year |  |  | Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for First PEO ($) |  |  | Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for First PEO ($) |  |  | Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year for First PEO ($) |  |  | Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for First PEO ($) |  |  | Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for First PEO ($) |  |  | Total - Inclusion of Equity Values for First PEO ($) |
| 2024 |  |  | 1,495,265 |  |  | 917,377 |  |  | 0 |  |  | 775,032 |  |  | 0 |  |  | 3,187,674 |
Non-PEO NEO Average Total Compensation Amount | $ 1,123,266 | 1,122,330 | 3,091,330 | 4,377,734 | 4,379,031
Non-PEO NEO Average Compensation Actually Paid Amount | $ 1,427,279 | (2,644) | (3,426,582) | 3,290,039 | 2,020,372
Adjustment to Non-PEO NEO Compensation Footnote |
3. | Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEO and the Non-PEO NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Exclusion of Stock Awards column are the totals from the Stock Awards column set forth in the Summary Compensation Table.
| Year |  |  | Average Summary Compensation Table Total for Non-PEO NEOs ($) |  |  | Average Exclusion of Stock Awards for Non-PEO NEOs ($) |  |  | Average Inclusion of Equity Values for Non-PEO NEOs ($) |  |  | Average Compensation Actually Paid to Non-PEO NEOs ($) |
| 2024 |  |  | 1,123,266 |  |  | (286,483) |  |  | 590,496 |  |  | 1,427,279 |
The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables:
| Year |  |  | Average Year- End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for Non- PEO NEOs ($) |  |  | Average Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for Non-PEO NEOs ($) |  |  | Average Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year for Non- PEO NEOs ($) |  |  | Average Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for Non-PEO NEOs ($) |  |  | Average Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for Non-PEO NEOs ($) |  |  | Total - Average Inclusion of Equity Values for Non-PEO NEOs ($) |
| 2024 |  |  | 271,086 |  |  | 153,951 |  |  | 0 |  |  | 165,459 |  |  | 0 |  |  | 590,496 |
Compensation Actually Paid vs. Total Shareholder Return | Relationship Between PEO and Non-PEO NEO Compensation Actually Paid and Total Shareholder Return (“TSR”) The following chart sets forth the relationship between Compensation Actually Paid to our PEO, the average of Compensation Actually Paid to our Non-PEO NEOs, and the cumulative TSR over the five most recently completed fiscal years for the Company and the Peer Group TSR. |  |  |  |
Compensation Actually Paid vs. Net Income | Relationship Between PEO and Non-PEO NEO Compensation Actually Paid and Net Income The following chart sets forth the relationship between Compensation Actually Paid to our PEO, the average of Compensation Actually Paid to our Non-PEO NEOs, and our net income during the five most recently completed fiscal years. |  |  |  |
Total Shareholder Return Vs Peer Group | Relationship Between PEO and Non-PEO NEO Compensation Actually Paid and Total Shareholder Return (“TSR”) The following chart sets forth the relationship between Compensation Actually Paid to our PEO, the average of Compensation Actually Paid to our Non-PEO NEOs, and the cumulative TSR over the five most recently completed fiscal years for the Company and the Peer Group TSR. |  |  |  |
Total Shareholder Return Amount | $ 4.31 | 2.62 | 10.47 | 62.59 | 78.76
Peer Group Total Shareholder Return Amount | 118.2 | 118.87 | 113.65 | 126.45 | 126.42
Net Income (Loss) | $ (119,000,000) | $ (276,000,000) | $ (368,000,000) | $ (524,000,000) | $ (444,000,000)
PEO Name | Howard Robin | Howard Robin | Howard Robin | Howard Robin | Howard Robin
Additional 402(v) Disclosure | We believe that our compensation structure supports our business strategy while successfully aligning executive focus and interests with those of the Company and our stockholders. We seek to incentivize long-term performance and achievement of milestones that are important to building sustained success for the Company. Our compensation structure includes several elements that collectively provide an effective compensation strategy that supports our philosophy of pay for performance. As discussed in the Compensation Discussion and Analysis section, the performance-based component of our NEO’s compensation is tied to the achievement of critical objective, performance milestones and annual corporate goals, which we believe provides strong performance incentives to our executives. |  |  |  |
Equity Awards Adjustments, Footnote | The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables:
| Year |  |  | Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for First PEO ($) |  |  | Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for First PEO ($) |  |  | Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year for First PEO ($) |  |  | Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for First PEO ($) |  |  | Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for First PEO ($) |  |  | Total - Inclusion of Equity Values for First PEO ($) |
| 2024 |  |  | 1,495,265 |  |  | 917,377 |  |  | 0 |  |  | 775,032 |  |  | 0 |  |  | 3,187,674 |
| Year |  |  | Average Year- End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for Non- PEO NEOs ($) |  |  | Average Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for Non-PEO NEOs ($) |  |  | Average Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year for Non- PEO NEOs ($) |  |  | Average Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for Non-PEO NEOs ($) |  |  | Average Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for Non-PEO NEOs ($) |  |  | Total - Average Inclusion of Equity Values for Non-PEO NEOs ($) |
| 2024 |  |  | 271,086 |  |  | 153,951 |  |  | 0 |  |  | 165,459 |  |  | 0 |  |  | 590,496 |
PEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | $ (1,596,122) |  |  |  |
PEO | Equity Awards Adjustments, Excluding Value Reported in Compensation Table |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 3,187,674 |  |  |  |
PEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 1,495,265 |  |  |  |
PEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 917,377 |  |  |  |
PEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 0 |  |  |  |
PEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 775,032 |  |  |  |
PEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 0 |  |  |  |
Non-PEO NEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | (286,483) |  |  |  |
Non-PEO NEO | Equity Awards Adjustments, Excluding Value Reported in Compensation Table |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 590,496 |  |  |  |
Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 271,086 |  |  |  |
Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 153,951 |  |  |  |
Non-PEO NEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 0 |  |  |  |
Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 165,459 |  |  |  |
Non-PEO NEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | $ 0 |  |  |  |

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