<SUBMISSION>
<ACCESSION-NUMBER>0001179110-07-014572
<TYPE>4
<PUBLIC-DOCUMENT-COUNT>1
<PERIOD>20070703
<FILING-DATE>20070706
<DATE-OF-FILING-DATE-CHANGE>20070706
<ISSUER>
<COMPANY-DATA>
<CONFORMED-NAME>PROS Holdings, Inc.
<CIK>0001392972
<ASSIGNED-SIC>7371
<IRS-NUMBER>760168604
<STATE-OF-INCORPORATION>DE
<FISCAL-YEAR-END>1231
</COMPANY-DATA>
<BUSINESS-ADDRESS>
<STREET1>3100 MAIN STREET
<STREET2>SUITE 900
<CITY>HOUSTON
<STATE>TX
<ZIP>77002
<PHONE>713-335-5151
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>3100 MAIN STREET
<STREET2>SUITE 900
<CITY>HOUSTON
<STATE>TX
<ZIP>77002
</MAIL-ADDRESS>
</ISSUER>
<REPORTING-OWNER>
<OWNER-DATA>
<CONFORMED-NAME>Jaggers Kurt R
<CIK>0001292149
</OWNER-DATA>
<FILING-VALUES>
<FORM-TYPE>4
<ACT>34
<FILE-NUMBER>001-33554
<FILM-NUMBER>07966792
</FILING-VALUES>
<BUSINESS-ADDRESS>
<PHONE>617-574-6700
</BUSINESS-ADDRESS>
<MAIL-ADDRESS>
<STREET1>125 HIGH STREET
<STREET2>SUITE 2500
<CITY>BOSTON
<STATE>MA
<ZIP>02110
</MAIL-ADDRESS>
</REPORTING-OWNER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>edgar.xml
<DESCRIPTION>FORM 4 -
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2007-07-03</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001392972</issuerCik>
        <issuerName>PROS Holdings, Inc.</issuerName>
        <issuerTradingSymbol>PRO</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001292149</rptOwnerCik>
            <rptOwnerName>Jaggers Kurt R</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>JOHN HANCOCK TOWER</rptOwnerStreet1>
            <rptOwnerStreet2>200 CLARENDON STREET, 56TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>BOSTON</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>21210</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2007-07-03</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>4441</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>10.23</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>21467</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F1"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">Kurt R. Jaggers may be deemed to have a beneficial interest in 99,350 shares of common stock of the issuer held of record by TA Investors LLC, of which he is a member.  Mr. Jaggers disclaims beneficial ownership of such shares, except to the extent of 21,467 shares of common stock as to which he holds a pecuniary interest.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>Kurt R. Jaggers</signatureName>
        <signatureDate>2007-07-06</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SUBMISSION>
