<SEC-DOCUMENT>0000950170-25-068039.txt : 20250509
<SEC-HEADER>0000950170-25-068039.hdr.sgml : 20250509
<ACCEPTANCE-DATETIME>20250509161503
ACCESSION NUMBER:		0000950170-25-068039
CONFORMED SUBMISSION TYPE:	SCHEDULE 13G
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20250509
DATE AS OF CHANGE:		20250509

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Maze Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001842295
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-94841
		FILM NUMBER:		25930596

	BUSINESS ADDRESS:	
		STREET 1:		171 OYSTER POINT BOULEVARD, SUITE 300
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
		BUSINESS PHONE:		6508505070

	MAIL ADDRESS:	
		STREET 1:		171 OYSTER POINT BOULEVARD, SUITE 300
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Third Rock Ventures IV, L.P.
		CENTRAL INDEX KEY:			0001688327
		ORGANIZATION NAME:           	
		EIN:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G

	BUSINESS ADDRESS:	
		STREET 1:		29 NEWBURY STREET, 3RD FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
		BUSINESS PHONE:		617-585-2000

	MAIL ADDRESS:	
		STREET 1:		29 NEWBURY STREET, 3RD FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
</SEC-HEADER>
<DOCUMENT>
<TYPE>SCHEDULE 13G
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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    <submissionType>SCHEDULE 13G</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001688327</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
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  <formData>
    <coverPageHeader>
      <securitiesClassTitle>Common Stock, $0.001 par value per share</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>01/31/2025</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001842295</issuerCik>
        <issuerName>Maze Therapeutics, Inc.</issuerName>
        <issuerCusip>578784100</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <street1 xmlns="http://www.sec.gov/edgar/common">171 Oyster Point Boulevard</street1>
          <street2 xmlns="http://www.sec.gov/edgar/common">Suite 300</street2>
          <city xmlns="http://www.sec.gov/edgar/common">San Francisco</city>
          <stateOrCountry xmlns="http://www.sec.gov/edgar/common">CA</stateOrCountry>
          <zipCode xmlns="http://www.sec.gov/edgar/common">94939</zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(d)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>Third Rock Ventures IV, L.P.</reportingPersonName>
      <memberGroup>b</memberGroup>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0</soleVotingPower>
        <sharedVotingPower>6073958</sharedVotingPower>
        <soleDispositivePower>0</soleDispositivePower>
        <sharedDispositivePower>6073958</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>6073958</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>13.9</classPercent>
      <typeOfReportingPerson>PN</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>Third Rock Ventures GP IV, L.P.</reportingPersonName>
      <memberGroup>b</memberGroup>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0</soleVotingPower>
        <sharedVotingPower>6073958</sharedVotingPower>
        <soleDispositivePower>0</soleDispositivePower>
        <sharedDispositivePower>6073958</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>6073958</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>13.9</classPercent>
      <typeOfReportingPerson>PN</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>TRV GP IV, LLC</reportingPersonName>
      <memberGroup>b</memberGroup>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0</soleVotingPower>
        <sharedVotingPower>6073958</sharedVotingPower>
        <soleDispositivePower>0</soleDispositivePower>
        <sharedDispositivePower>6073958</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>6073958</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>13.9</classPercent>
      <typeOfReportingPerson>OO</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>Third Rock Ventures V, L.P.</reportingPersonName>
      <memberGroup>b</memberGroup>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0</soleVotingPower>
        <sharedVotingPower>950800</sharedVotingPower>
        <soleDispositivePower>0</soleDispositivePower>
        <sharedDispositivePower>950800</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>950800</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>2.2</classPercent>
      <typeOfReportingPerson>PN</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>Third Rock Ventures GP V, L.P.</reportingPersonName>
      <memberGroup>b</memberGroup>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0</soleVotingPower>
        <sharedVotingPower>950800</sharedVotingPower>
        <soleDispositivePower>0</soleDispositivePower>
        <sharedDispositivePower>950800</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>950800</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>2.2</classPercent>
      <typeOfReportingPerson>PN</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>TRV GP V, LLC</reportingPersonName>
      <memberGroup>b</memberGroup>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0</soleVotingPower>
        <sharedVotingPower>950800</sharedVotingPower>
        <soleDispositivePower>0</soleDispositivePower>
        <sharedDispositivePower>950800</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>950800</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>2.2</classPercent>
      <typeOfReportingPerson>OO</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>Maze Therapeutics, Inc.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>171 Oyster Point Boulevard, Suite 300, San Francisco, CA 94939</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>(i)   Third Rock Ventures IV, L.P. ("TRV IV");
(ii)  Third Rock Ventures GP IV, L.P. ("TRV GP IV"), which is the sole general partner of TRV IV;
(iii) TRV GP IV, LLC ("TRV GP IV LLC"), which is the sole general partner of TRV GP IV;
(iv) Third Rock Ventures V, L.P. ("TRV V");
(v)  Third Rock Ventures GP V, L.P. ("TRV GP V"), which is the sole general partner of TRV V; and
(vi)  TRV GP V, LLC ("TRV GP V LLC"), which is the sole general partner of TRV GP V.</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>The address of the principal business office of each of the Reporting Persons is Third Rock Ventures, LLC, 201 Brookline Ave, Suite 1401, Boston, MA 02215.</principalBusinessOfficeOrResidenceAddress>
        <citizenship>Each of TRV IV, TRV GP IV, TRV V and TRV GP V is a Delaware limited partnership. Each of TRV GP IV LLC and TRV GP V LLC is a Delaware limited liability company.</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>(i) TRV IV directly owns 6,073,958 shares of Common Stock (the "IV Shares")
(ii) TRV GP IV is the general partner of TRV IV and may be deemed to beneficially own the IV Shares.
(iii) TRV GP IV LLC is the general partner of TRV GP IV and may be deemed to beneficially own the IV Shares.
(iv) TRV V directly owns 950,800 shares of Common Stock (the "V Shares").
(v) TRV GP V is the general partner of TRV V and may be deemed to beneficially own the V Shares.
(vi)  TRV GP V LLC is the general partner of TRV GP V and may be deemed to beneficially own the V Shares.

Each of TRV IV, TRV GP IV, and TRV GP IV LLC, on the one hand, and TRV V, TRV GP V and TRV GP V LLC, on the other hand, disclaim the existence of a "group" for purposes of Rule 13d-5 of the Securities Exchange Act of 1934, as amended, and nothing contained in this report shall be deemed an admission that any such group exists or may exist.</amountBeneficiallyOwned>
        <classPercent>The IV shares represent approximately 13.9% of the outstanding shares of Common Stock.
The V shares represent approximately 2.2% of the outstanding shares of Common Stock.
The percent of class was calculated based on 43,796,057 shares of common stock issued and outstanding as of March 25, 2025, as disclosed in the Issuer's 10-K filed with the Securities and Exchange Commission on March 31, 2025.</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>TRV IV - 0
TRV GP IV - 0
TRV GP IV LLC - 0
TRV V	 - 0
TRV GP V - 0
TRV GP V LLC - 0</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>TRV IV - 6,073,958 shares
TRV GP IV - 6,073,958 shares
TRV GP IV LLC - 6,073,958 shares
TRV V	 - 950,800 shares
TRV GP V - 950,800 shares
TRV GP V LLC - 950,800 shares</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>TRV IV - 0
TRV GP IV - 0
TRV GP IV LLC - 0
TRV V	 - 0
TRV GP V - 0
TRV GP V LLC - 0</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>TRV IV - 6,073,958 shares
TRV GP IV - 6,073,958 shares
TRV GP IV LLC - 6,073,958 shares
TRV V	 - 950,800 shares
TRV GP V - 950,800 shares
TRV GP V LLC - 950,800 shares</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>Y</notApplicableFlag>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>Third Rock Ventures IV, L.P.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Kevin Gillis</signature>
        <title>Kevin Gillis, Chief Operating Officer of TRV GP IV, LLC, gen. partner of Third Rock Ventures GP IV, L.P., gen. partner of Third Rock Ventures IV, L.P.</title>
        <date>05/09/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Third Rock Ventures GP IV, L.P.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Kevin Gillis</signature>
        <title>Kevin Gillis, Chief Operating Officer of TRV GP IV, LLC, general partner of Third Rock Ventures GP IV, L.P</title>
        <date>05/09/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>TRV GP IV, LLC</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Kevin Gillis</signature>
        <title>Kevin Gillis, Chief Operating Officer of TRV GP IV, LLC</title>
        <date>05/09/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Third Rock Ventures V, L.P.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Kevin Gillis</signature>
        <title>Kevin Gillis, Chief Operating Officer of TRV GP V, LLC, gen. partner of Third Rock Ventures GP V, L.P., gen. partner of Third Rock Ventures V, L.P.</title>
        <date>05/09/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Third Rock Ventures GP V, L.P.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Kevin Gillis</signature>
        <title>Kevin Gillis, Chief Operating Officer of TRV GP V, LLC, general partner of Third Rock Ventures GP V, L.P.</title>
        <date>05/09/2025</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>TRV GP V, LLC</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Kevin Gillis</signature>
        <title>Kevin Gillis, Chief Operating Officer of TRV GP V, LLC</title>
        <date>05/09/2025</date>
      </signatureDetails>
    </signatureInformation>
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