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Commitments and Contingencies | 12 Months Ended
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Dec. 31, 2022
Commitments and Contingencies Disclosure [Abstract] |
Commitments and Contingencies | Commitments and Contingencies Leases In May 2021, the Company entered into a sublease agreement for office space located in Boston, Massachusetts. The sublease expires on January 31, 2026, with no option to renew or terminate early. The base rent increases by approximately 2% annually. The Company issued a letter of credit to the landlord related to the security deposit, secured by restricted cash (Note 3). This lease qualifies as an operating lease. At inception, the Company recorded an operating lease right-of-use asset and operating lease liability of $4.1 million. In October 2018, the Company entered into a sublease agreement for office space located in Cambridge, Massachusetts which expired on December 31, 2021. The base rent increased by approximately 1% annually. The Company issued a letter of credit to the landlord related to the security deposit, secured by restricted cash (Note 3). This lease qualified as an operating lease. The following table summarizes the presentation of the operating leases in the Company’s consolidated balance sheets (in thousands):
| As of December 31,
| 2022 |  | 2021
Assets: |  |  |
Operating lease right-of-use assets | $ | 2,901 |  |  | $ | 3,653 |
Liabilities: |  |  |
Current operating lease liabilities | $ | 1,005 |  |  | $ | 810 |
Non-current portion of operating lease liabilities | 2,495 |  |  | 3,501 |
Total lease liabilities | $ | 3,500 |  |  | $ | 4,311 |
The following table summarizes total lease costs recognized in the Company’s consolidated statements of operations (in thousands):
| For the year ended December 31,
| 2022 |  | 2021
Operating lease cost | $ | 1,102 |  |  | $ | 1,412 |
Variable lease costs | 37 |  |  | 34 |
Total lease costs | $ | 1,139 |  |  | $ | 1,446 |
Variable lease costs were primarily related to operating expenses, taxes and insurance associated with the operating leases, which were assessed based on the Company’s proportionate share of such costs for the leased premises. As these costs are generally variable in nature, they were not included in the measurement of the operating lease right-of-use asset and related lease liability. Total lease costs are included as operating expenses in the Company’s consolidated statements of operations and comprehensive loss. Future lease payments under non-cancelable lease agreements as of December 31, 2022 were as follows (in thousands):
Year Ended December 31, | Future Lease Payments
2023 | $ | 1,270 |
2024 | 1,296 |
2025 | 1,321 |
2026 | 110 |
Total future lease payments | $ | 3,997 |
Less: interest | (497) |
Present value of operating lease liabilities | $ | 3,500 |
The weighted average remaining lease term and weighted average incremental borrowing rate of the Company’s operating lease were as follows:
| As of December 31,
| 2022 |  | 2021
Weighted average remaining lease term (in years) | 3.1 |  | 4.1
Weighted average incremental borrowing rate | 9.0 | % |  | 9.0 | %
Legal Proceedings The Company, from time to time, may be party to litigation arising in the ordinary course of business. The Company was not subject to any material legal proceedings during the years ended December 31, 2022 and 2021, and no material legal proceedings are currently pending or threatened. Purchase Orders The Company has agreements with third parties for various services, including services related to research, preclinical and clinical operations and support, for which the Company is not contractually able to terminate for convenience to avoid future obligations to the vendors. Certain agreements provide for termination rights subject to termination fees or wind down costs. Under such agreements, the Company is contractually obligated to make certain payments to vendors, primarily to reimburse them for their unrecoverable outlays incurred prior to cancellation. The actual amounts the Company could pay in the future to the vendors under such agreements may differ from the purchase order amounts due to cancellation provisions. Indemnification Agreements The Company enters into indemnification agreements and agreements containing indemnification provisions in the ordinary course of business. Pursuant to these agreements, the Company agrees to indemnify, hold harmless, and to reimburse the indemnified party for losses suffered or incurred by the indemnified party, generally the Company’s business partners, in connection with any U.S. patent or any copyright or other intellectual property infringement claim by any third party with respect to the Company’s products. The term of these indemnification agreements is generally perpetual upon execution of the agreement. The maximum potential amount of future payments the Company could be required to make under these indemnification agreements is unlimited. The Company has never incurred costs to defend lawsuits or settle claims related to these indemnification agreements. Agreements The Company has entered into multiple agreements with third parties under which it may be obligated to make future development, regulatory and commercial milestone payments and royalty payments on future sales of specified product candidates. Payments under these agreements generally become due and payable upon achievement of such milestones and sales. When the achievement of these milestones or sales have not occurred, such contingencies are not recorded in the Company's financial statements.

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