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Stock-Based Compensation (Tables)
12 Months Ended
Dec. 31, 2022
Share-Based Payment Arrangement [Abstract]  
Summary of restricted stock activity
The following table summarizes the Company’s restricted stock unit activity:
SharesWeighted
Average
Grant Date
Fair Value
Unvested as of December 31, 2021440,079 $41.86 
Issued676,828 14.54 
Vested(104,803)44.89 
Forfeited(268,154)22.08 
Unvested as of December 31, 2022743,950 $23.07 
Summary of stock option activity
The following table summarizes the Company’s stock option activity:
Number of
Shares
Weighted
Average
Exercise Price
per Share
Weighted
Average
Remaining
Contractual
Term
Aggregate
Intrinsic Value
   (In years)(In thousands)
Outstanding as of December 31, 20216,468,501 $16.92 
Granted3,969,302 9.23 
Exercised(265,662)3.04 $850 
Cancelled or Forfeited(1,334,113)16.64 
Outstanding as of December 31, 20228,838,028 $13.93 8.26$514 
Exercisable as of December 31, 20223,315,240 $14.86 7.50$95 
Vested and expected to vest as of December 31, 20228,635,022 $13.90 8.30$497 
Schedule of fair value of stock option awards on the grant date using the Black-Scholes option valuation model
 Year Ended December 31,
 20222021
Risk-free interest rate2.52 %0.86 %
Expected term (in years)6.076.08
Expected volatility89.20 %85.52 %
Expected dividend yield— %— %
Weighted average grant-date fair value per share$6.65 $27.58 
Summary of stock-based compensation expense
Stock-based compensation expense was allocated as follows (in thousands):
 Year Ended December 31,
 20222021
Research and development$9,972 $9,350 
General and administrative18,621 13,343 
Total stock-based compensation expense$28,593 $22,693