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Consolidated Statements of Stockholders' Equity - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-In Capital
Accumulated Deficit
Accumulated Other Comprehensive Loss
Beginning balance (in shares) at Dec. 31, 2020   38,268,543      
Beginning balance at Dec. 31, 2020 $ 287,457 $ 4 $ 437,007 $ (149,554) $ 0
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Stock-based compensation expense 4,666   4,666    
Issuance of common stock upon exercise of stock options (in shares)   352,506      
Issuance of common stock upon exercise of stock options 851   851    
Change in unrealized loss on marketable securities, net of tax (86)       (86)
Net loss (27,373)     (27,373)  
Ending balance (in shares) at Mar. 31, 2021   38,621,049      
Ending balance at Mar. 31, 2021 265,515 $ 4 442,524 (176,927) (86)
Beginning balance (in shares) at Dec. 31, 2020   38,268,543      
Beginning balance at Dec. 31, 2020 287,457 $ 4 437,007 (149,554) 0
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Net loss $ (167,061)        
Ending balance (in shares) at Dec. 31, 2021 45,300,514 45,300,514      
Ending balance at Dec. 31, 2021 $ 250,812 $ 5 567,598 (316,615) (176)
Beginning balance (in shares) at Mar. 31, 2021   38,621,049      
Beginning balance at Mar. 31, 2021 265,515 $ 4 442,524 (176,927) (86)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Stock-based compensation expense 5,400   5,400    
Issuance of common stock from at-the-market public offerings (in shares)   5,750,000      
Issuance of common stock from at-the-market public offerings 98,413 $ 1 98,412    
Issuance of common stock upon exercise of stock options (in shares)   322,113      
Issuance of common stock upon exercise of stock options 809   809    
Change in unrealized loss on marketable securities, net of tax 36       36
Net loss (36,401)     (36,401)  
Ending balance (in shares) at Jun. 30, 2021   44,693,162      
Ending balance at Jun. 30, 2021 333,772 $ 5 547,145 (213,328) (50)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Stock-based compensation expense 6,521   6,521    
Issuance of common stock upon exercise of stock options (in shares)   90,909      
Issuance of common stock upon exercise of stock options 309   309    
Change in unrealized loss on marketable securities, net of tax 25       25
Net loss (44,705)     (44,705)  
Ending balance (in shares) at Sep. 30, 2021   44,784,071      
Ending balance at Sep. 30, 2021 295,922 $ 5 553,975 (258,033) (25)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Stock-based compensation expense 6,106   6,106    
Issuance of common stock from at-the-market public offerings (in shares)   391,997      
Issuance of common stock from at-the-market public offerings 7,039   7,039    
Issuance of common stock upon exercise of stock options (in shares)   124,446      
Issuance of common stock upon exercise of stock options 478   478    
Change in unrealized loss on marketable securities, net of tax (151)       (151)
Net loss $ (58,582)     (58,582)  
Ending balance (in shares) at Dec. 31, 2021 45,300,514 45,300,514      
Ending balance at Dec. 31, 2021 $ 250,812 $ 5 567,598 (316,615) (176)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Stock-based compensation expense 7,886   7,886    
Issuance of common stock from at-the-market public offerings (in shares)   70,410      
Issuance of common stock from at-the-market public offerings 1,368   1,368    
Vesting of restricted stock units (in shares)   81,130      
Shares witheld for taxes for vesting of restricted stock units (in shares)   (17,850)      
Shares withheld for taxes for vesting of restricted stock units (230)   (230)    
Issuance of common stock upon exercise of stock options (in shares)   72,278      
Issuance of common stock upon exercise of stock options 333   333    
Change in unrealized loss on marketable securities, net of tax (430)       (430)
Net loss (68,717)     (68,717)  
Ending balance (in shares) at Mar. 31, 2022   45,506,482      
Ending balance at Mar. 31, 2022 $ 191,022 $ 5 576,955 (385,332) (606)
Beginning balance (in shares) at Dec. 31, 2021 45,300,514 45,300,514      
Beginning balance at Dec. 31, 2021 $ 250,812 $ 5 567,598 (316,615) (176)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Issuance of common stock upon exercise of stock options (in shares) 265,662        
Net loss $ (214,029)        
Ending balance (in shares) at Dec. 31, 2022 49,382,453 49,382,453      
Ending balance at Dec. 31, 2022 $ 76,106 $ 5 606,918 (530,644) (173)
Beginning balance (in shares) at Mar. 31, 2022   45,506,482      
Beginning balance at Mar. 31, 2022 191,022 $ 5 576,955 (385,332) (606)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Stock-based compensation expense 7,611   7,611    
Issuance of common stock under employee stock purchase plan (in shares)   51,645      
Issuance of common stock under employee stock purchase plan 454   454    
Vesting of restricted stock units (in shares)   6,361      
Shares witheld for taxes for vesting of restricted stock units (in shares)   (2,225)      
Shares withheld for taxes for vesting of restricted stock units (17)   (17)    
Issuance of common stock upon exercise of stock options (in shares)   13,143      
Issuance of common stock upon exercise of stock options 67   67    
Change in unrealized loss on marketable securities, net of tax (74)       (74)
Net loss (60,194)     (60,194)  
Ending balance (in shares) at Jun. 30, 2022   45,575,406      
Ending balance at Jun. 30, 2022 138,869 $ 5 585,070 (445,526) (680)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Stock-based compensation expense 6,730   6,730    
Issuance of common stock from at-the-market public offerings (in shares)   1,105,006      
Issuance of common stock from at-the-market public offerings 2,962   2,962    
Vesting of restricted stock units (in shares)   5,312      
Shares witheld for taxes for vesting of restricted stock units (in shares)   (1,638)      
Shares withheld for taxes for vesting of restricted stock units (6)   (6)    
Issuance of common stock upon exercise of stock options (in shares)   180,241      
Issuance of common stock upon exercise of stock options 409   409    
Change in unrealized loss on marketable securities, net of tax 144       144
Net loss (43,945)     (43,945)  
Ending balance (in shares) at Sep. 30, 2022   46,864,327      
Ending balance at Sep. 30, 2022 105,163 $ 5 595,165 (489,471) (536)
Increase (Decrease) in Stockholders' Equity [Roll Forward]          
Stock-based compensation expense 6,366   6,366    
Issuance of common stock under employee stock purchase plan (in shares)   89,739      
Issuance of common stock under employee stock purchase plan 163   163    
Issuance of common stock from at-the-market public offerings (in shares)   2,419,857      
Issuance of common stock from at-the-market public offerings 5,231   5,231    
Vesting of restricted stock units (in shares)   12,000      
Shares witheld for taxes for vesting of restricted stock units (in shares)   (3,470)      
Shares withheld for taxes for vesting of restricted stock units (7)   (7)    
Change in unrealized loss on marketable securities, net of tax 363       363
Net loss $ (41,173)     (41,173)  
Ending balance (in shares) at Dec. 31, 2022 49,382,453 49,382,453      
Ending balance at Dec. 31, 2022 $ 76,106 $ 5 $ 606,918 $ (530,644) $ (173)