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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Cash flows from operating activities:    
Net loss $ (214,029) $ (167,061)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation expense 419 182
Stock-based compensation expense 28,593 22,693
Non-cash operating lease expense 752 1,412
Amortization of premiums and discounts on marketable securities, net 1,003 2,087
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 547 (5,780)
Accounts payable 3,892 7,267
Accrued expenses (10,465) 15,450
Operating lease liabilities (811) (763)
Deferred revenue 5,000 0
Other 56 (41)
Net cash used in operating activities (185,043) (124,554)
Cash flows from investing activities:    
Purchases of property and equipment (444) (1,050)
Purchases of marketable securities (83,022) (164,170)
Maturities of marketable securities 180,355 24,700
Net cash provided by (used in) investing activities 96,889 (140,520)
Cash flows from financing activities:    
Proceeds from at-the-market offerings, net of issuance costs 9,561 7,301
Proceeds from follow-on public offering, net of issuance costs 0 98,413
Payment of issuance costs for at-the-market offerings and initial public offering (262) (575)
Payments of tax withholdings related to vesting of restricted stock units (260) 0
Proceeds from exercise of options and employee stock purchase plan contributions 1,426 2,447
Net cash provided by financing activities 10,465 107,586
Decrease in cash, cash equivalents and restricted cash (77,689) (157,488)
Cash, cash equivalents and restricted cash, beginning of period 139,720 297,208
Cash, cash equivalents and restricted cash, end of period 62,031 139,720
Reconciliation of cash, cash equivalents and restricted cash:    
Cash and cash equivalents 61,615 138,704
Restricted cash 416 1,016
Total cash, cash equivalents and restricted cash 62,031 139,720
Supplemental disclosures of non-cash activities:    
Operating lease right-of-use assets obtained in exchange for operating lease liabilities 0 4,068
Offering costs included in accrued expenses 0 262
Purchases of property and equipment included in accrued expenses $ 0 $ 267