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Accrued Expenses
6 Months Ended
Jun. 30, 2023
Payables and Accruals [Abstract]  
Accrued Expenses Accrued ExpensesAccrued expenses consisted of the following (in thousands):
June 30, 2023December 31, 2022
Accrued external research and development expenses$3,972 $10,734 
Accrued milestone expense6,937 — 
Accrued personnel-related expenses1,617 2,803 
Accrued other expenses791 2,313 
Total accrued expenses$13,317 $15,850 
At June 30, 2023, accrued expenses included $6.9 million of milestone expense related to the Research Collaboration, Option and License Agreement between the Company and Ionis Pharmaceuticals, Inc., earned upon initiation of the Company's PRAX-222 EMBRAVE study in the second quarter of 2023. The milestone was paid in July 2023.