<SEC-DOCUMENT>0000899140-23-000377.txt : 20230214
<SEC-HEADER>0000899140-23-000377.hdr.sgml : 20230214
<ACCEPTANCE-DATETIME>20230214160905
ACCESSION NUMBER:		0000899140-23-000377
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20230214
DATE AS OF CHANGE:		20230214
GROUP MEMBERS:		72 INVESTMENT HOLDINGS, LLC
GROUP MEMBERS:		CUBIST SYSTEMATIC STRATEGIES, LLC
GROUP MEMBERS:		DIFFERENTIATED VENTURES INVESTMENTS, LLC
GROUP MEMBERS:		POINT72 BIOTECH PRIVATE INVESTMENTS, LLC
GROUP MEMBERS:		POINT72 CAPITAL ADVISORS, INC.
GROUP MEMBERS:		POINT72 HONG KONG LTD
GROUP MEMBERS:		POINT72 MIDDLE EAST FZE
GROUP MEMBERS:		STEVEN A. COHEN

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Praxis Precision Medicines, Inc.
		CENTRAL INDEX KEY:			0001689548
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-92098
		FILM NUMBER:		23629176

	BUSINESS ADDRESS:	
		STREET 1:		99 HIGH STREET, 30TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110
		BUSINESS PHONE:		617-300-8460

	MAIL ADDRESS:	
		STREET 1:		99 HIGH STREET, 30TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Point72 Asset Management, L.P.
		CENTRAL INDEX KEY:			0001603466
		IRS NUMBER:				465064661
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		72 CUMMINGS POINT ROAD
		CITY:			STAMFORD
		STATE:			CT
		ZIP:			06902
		BUSINESS PHONE:		203-890-2000

	MAIL ADDRESS:	
		STREET 1:		72 CUMMINGS POINT ROAD
		CITY:			STAMFORD
		STATE:			CT
		ZIP:			06902
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>pt7213gaa.htm
<DESCRIPTION>SCHEDULE 13G/A, AMENDMENT #2
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: Willkie Farr & Gallagher
         Document created using Broadridge PROfile 23.1.1.5115
         Copyright 1995 - 2023 Broadridge -->
  </head>
<body bgcolor="#ffffff" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;">
  <div>
    <div style="font-size: 12pt; font-weight: bold;">240.13d-102 Schedule 13G - Information to be included in statements filed</div>
    <div style="font-size: 12pt; font-weight: bold;">pursuant to 240.13d-1(b), (c), and (d) and amendments thereto</div>
    <div style="font-size: 12pt; font-weight: bold;">filed pursuant to 240.13d-2.</div>
    <div><br>
    </div>
    <div>
      <div style="text-indent: -24pt; margin-left: 24pt; font-size: 12pt;">Securities and Exchange Commission, Washington, D.C. 20549</div>
      <div><br>
      </div>
    </div>
    <div>
      <div style="font-size: 12pt;">Schedule 13G</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">Under the Securities Exchange Act of 1934</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">(Amendment No. 2)*</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">(Name of Issuer)</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">Praxis Precision Medicines, Inc.</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">(Title of Class of Securities)</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">Common Stock, par value $0.0001 per share</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">(CUSIP Number)</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">74006W108</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">(Date of Event Which Requires Filing of this Statement)</div>
    </div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">December 31, 2022</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">Check the appropriate box to designate the rule pursuant to which this</div>
    <div style="font-size: 12pt;">Schedule is filed:</div>
    <div><br>
    </div>
    <div>
      <div style="text-indent: -24pt; margin-left: 24pt; font-size: 12pt;">[&#160; ] Rule 13d-1(b)</div>
      <div><br>
      </div>
      <div style="text-indent: -24pt; margin-left: 24pt; font-size: 12pt;">[ x ] Rule 13d-1(c)</div>
      <div><br>
      </div>
      <div style="text-indent: -24pt; margin-left: 24pt; font-size: 12pt;">[&#160; ] Rule 13d-1(d)</div>
      <div><br>
      </div>
    </div>
    <div>
      <div style="font-size: 12pt;">*The remainder of this cover page shall be filled out for a reporting person's<br>
        initial filing on this form with respect to the subject class of securities, and<br>
        for any subsequent amendment containing information which would alter the<br>
        disclosures provided in a prior cover page.</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">The information required in the remainder of this cover page shall not be<br>
        deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the Securities Exchange<br>
        Act of 1934 (&#8220;Act&#8221;) or otherwise subject to the liabilities of that section of the<br>
        Act but shall be subject to all other provisions of the Act (however, see<br>
        the Notes).</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div class="BRPFPageBreak" style="page-break-after:always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <div><br>
      </div>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z51277caaa1d84f448664f34bfdddeefc">

        <tr>
          <td colspan="2" style="width: 100%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-size: 12pt;">CUSIP No. 74006W108</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(1) Names of reporting persons&#160; &#160; Point72 Asset Management, L.P.</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(2) Check the appropriate box if a member of a group</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(a)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-indent: 176.2pt; font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(b)X</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(3) SEC use only</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(4) Citizenship or place of organization Delaware</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">Number of shares beneficially owned by each reporting person with:</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(5) Sole voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 0</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(6) Shared voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; 100,000</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(7) Sole dispositive power&#160; &#160; &#160; &#160; &#160;&#160; 0</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(8) Shared dispositive power&#160; &#160; &#160;&#160; 100,000</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(9) Aggregate amount beneficially owned by each reporting person</div>
            <div style="margin-left: 21.6pt; font-size: 12pt;">100,000</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(10) Check if the aggregate amount in Row (9) excludes certain shares</div>
            <div style="font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(11) Percent of class represented by amount in Row (9) 0.2%</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(12) Type of reporting person (see instructions) PN</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>

    </table>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="margin-bottom: 10pt;"><br>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zda8a13d791b14f5994ec573315cf90c9">

        <tr>
          <td colspan="2" style="width: 100%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-size: 12pt;">CUSIP No. 74006W108</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(1) Names of reporting persons&#160; &#160; Point72 Capital Advisors, Inc.</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(2) Check the appropriate box if a member of a group</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(a)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-indent: 176.2pt; font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(b)X</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(3) SEC use only</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(4) Citizenship or place of organization Delaware</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">Number of shares beneficially owned by each reporting person with:</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(5) Sole voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 0</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(6) Shared voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; 100,000</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(7) Sole dispositive power&#160; &#160; &#160; &#160; &#160;&#160; 0</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(8) Shared dispositive power&#160; &#160; &#160;&#160; 100,000</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(9) Aggregate amount beneficially owned by each reporting person</div>
            <div style="margin-left: 21.6pt; font-size: 12pt;">100,000</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(10) Check if the aggregate amount in Row (9) excludes certain shares</div>
            <div style="font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(11) Percent of class represented by amount in Row (9) 0.2%</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(12) Type of reporting person (see instructions) CO</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>

    </table>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="margin-bottom: 10pt;"><br>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z3a79669964cc4221bd501156240e4fde">

        <tr>
          <td colspan="2" style="width: 100%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-size: 12pt;">CUSIP No. 74006W108</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(1) Names of reporting persons&#160; &#160; Cubist Systematic Strategies, LLC</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(2) Check the appropriate box if a member of a group</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(a)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-indent: 176.2pt; font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(b)X</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(3) SEC use only</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(4) Citizenship or place of organization Delaware</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">Number of shares beneficially owned by each reporting person with:</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(5) Sole voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 0</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(6) Shared voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; 17,920</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(7) Sole dispositive power&#160; &#160; &#160; &#160; &#160;&#160; 0</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(8) Shared dispositive power&#160; &#160; &#160;&#160; 17,920</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(9) Aggregate amount beneficially owned by each reporting person</div>
            <div style="margin-left: 21.6pt; font-size: 12pt;">17,920</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(10) Check if the aggregate amount in Row (9) excludes certain shares</div>
            <div style="font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(11) Percent of class represented by amount in Row (9) &lt;0.1%</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(12) Type of reporting person (see instructions) OO</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>

    </table>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="margin-bottom: 10pt;"><br>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z02635ea11cb84725a6dad8ec720bca1f">

        <tr>
          <td style="width: 93.14%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-size: 12pt;">CUSIP No. 74006W108</div>
          </td>
          <td style="width: 6.86%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.14%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(1) Names of reporting persons&#160; &#160; Point72 Hong Kong Limited</div>
          </td>
          <td style="width: 6.86%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.14%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(2) Check the appropriate box if a member of a group</div>
          </td>
          <td style="width: 6.86%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(a)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.14%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-indent: 176.2pt; font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 6.86%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(b)X</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.14%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(3) SEC use only</div>
          </td>
          <td style="width: 6.86%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.14%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(4) Citizenship or place of organization Hong Kong</div>
          </td>
          <td style="width: 6.86%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.14%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">Number of shares beneficially owned by each reporting person with:</div>
          </td>
          <td style="width: 6.86%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.14%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(5) Sole voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 0</div>
          </td>
          <td style="width: 6.86%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.14%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(6) Shared voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; 0</div>
          </td>
          <td style="width: 6.86%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.14%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(7) Sole dispositive power&#160; &#160; &#160; &#160; &#160;&#160; 0</div>
          </td>
          <td style="width: 6.86%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.14%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(8) Shared dispositive power&#160; &#160; &#160;&#160; 0</div>
          </td>
          <td style="width: 6.86%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.14%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(9) Aggregate amount beneficially owned by each reporting person</div>
            <div style="margin-left: 21.6pt; font-size: 12pt;">0</div>
          </td>
          <td style="width: 6.86%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.14%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(10) Check if the aggregate amount in Row (9) excludes certain shares</div>
            <div style="font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 6.86%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.14%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(11) Percent of class represented by amount in Row (9) 0%</div>
          </td>
          <td style="width: 6.86%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.14%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(12) Type of reporting person (see instructions) OO</div>
          </td>
          <td style="width: 6.86%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>

    </table>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="margin-bottom: 10pt;"><br>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="ze902030b16f54fd3b6d991a34d379d5a">

        <tr>
          <td colspan="2" style="width: 100%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-size: 12pt;">CUSIP No. 74006W108</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(1) Names of reporting persons&#160; &#160; Point72 Middle East FZE</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(2) Check the appropriate box if a member of a group</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(a)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-indent: 176.2pt; font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(b)X</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(3) SEC use only</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(4) Citizenship or place of organization United Arab Emirates</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">Number of shares beneficially owned by each reporting person with:</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(5) Sole voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 0</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(6) Shared voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; 2,269</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(7) Sole dispositive power&#160; &#160; &#160; &#160; &#160;&#160; 0</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(8) Shared dispositive power&#160; &#160; &#160;&#160; 2,269</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(9) Aggregate amount beneficially owned by each reporting person</div>
            <div style="margin-left: 21.6pt; font-size: 12pt;">2,269</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(10) Check if the aggregate amount in Row (9) excludes certain shares</div>
            <div style="font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(11) Percent of class represented by amount in Row (9) &lt;0.1%</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(12) Type of reporting person (see instructions) OO</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>

    </table>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="margin-bottom: 10pt;"><br>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z3a208c0326d3400a9aa848028ead4942">

        <tr>
          <td colspan="2" style="width: 100%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-size: 12pt;">CUSIP No. 74006W108</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(1) Names of reporting persons&#160; &#160; Point72 Biotech Private Investments, LLC</div>
          </td>
          <td style="width: 6.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(2) Check the appropriate box if a member of a group</div>
          </td>
          <td style="width: 6.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(a)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-indent: 176.2pt; font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 6.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(b)X</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(3) SEC use only</div>
          </td>
          <td style="width: 6.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(4) Citizenship or place of organization United States</div>
          </td>
          <td style="width: 6.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">Number of shares beneficially owned by each reporting person with:</div>
          </td>
          <td style="width: 6.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(5) Sole voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 0</div>
          </td>
          <td style="width: 6.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(6) Shared voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; 988,995</div>
          </td>
          <td style="width: 6.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(7) Sole dispositive power&#160; &#160; &#160; &#160; &#160;&#160; 0</div>
          </td>
          <td style="width: 6.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(8) Shared dispositive power&#160; &#160; &#160;&#160; 988,995</div>
          </td>
          <td style="width: 6.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(9) Aggregate amount beneficially owned by each reporting person</div>
            <div style="margin-left: 21.6pt; font-size: 12pt;">988,995</div>
          </td>
          <td style="width: 6.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(10) Check if the aggregate amount in Row (9) excludes certain shares</div>
            <div style="font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 6.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(11) Percent of class represented by amount in Row (9) 2.0%</div>
          </td>
          <td style="width: 6.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.82%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(12) Type of reporting person (see instructions) OO</div>
          </td>
          <td style="width: 6.18%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>

    </table>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="margin-bottom: 10pt;"><br>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z46771699957349b7ae8f67afd7345268">

        <tr>
          <td colspan="2" style="width: 100%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-size: 12pt;">CUSIP No. 74006W108</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.81%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(1) Names of reporting persons&#160; &#160; Differentiated Ventures Investments, LLC</div>
          </td>
          <td style="width: 6.19%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.81%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(2) Check the appropriate box if a member of a group</div>
          </td>
          <td style="width: 6.19%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(a)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.81%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-indent: 176.2pt; font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 6.19%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(b)X</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.81%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(3) SEC use only</div>
          </td>
          <td style="width: 6.19%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.81%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(4) Citizenship or place of organization Delaware</div>
          </td>
          <td style="width: 6.19%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.81%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">Number of shares beneficially owned by each reporting person with:</div>
          </td>
          <td style="width: 6.19%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.81%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(5) Sole voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 0</div>
          </td>
          <td style="width: 6.19%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.81%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(6) Shared voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; 988,995</div>
          </td>
          <td style="width: 6.19%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.81%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(7) Sole dispositive power&#160; &#160; &#160; &#160; &#160;&#160; 0</div>
          </td>
          <td style="width: 6.19%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.81%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(8) Shared dispositive power&#160; &#160; &#160;&#160; 988,995</div>
          </td>
          <td style="width: 6.19%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.81%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(9) Aggregate amount beneficially owned by each reporting person</div>
            <div style="margin-left: 21.6pt; font-size: 12pt;">988,995</div>
          </td>
          <td style="width: 6.19%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.81%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(10) Check if the aggregate amount in Row (9) excludes certain shares</div>
            <div style="font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 6.19%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.81%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(11) Percent of class represented by amount in Row (9) 2.0%</div>
          </td>
          <td style="width: 6.19%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.81%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(12) Type of reporting person (see instructions) OO</div>
          </td>
          <td style="width: 6.19%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>

    </table>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="margin-bottom: 10pt;"><br>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z773d789ee0a1449e818855e7508fb2bb">

        <tr>
          <td colspan="2" style="width: 100%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-size: 12pt;">CUSIP No. 74006W108</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(1) Names of reporting persons&#160; &#160; 72 Investment Holdings, LLC</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(2) Check the appropriate box if a member of a group</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(a)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-indent: 176.2pt; font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(b)X</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(3) SEC use only</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(4) Citizenship or place of organization Delaware</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">Number of shares beneficially owned by each reporting person with:</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(5) Sole voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 0</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(6) Shared voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; 988,995</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(7) Sole dispositive power&#160; &#160; &#160; &#160; &#160;&#160; 0</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(8) Shared dispositive power&#160; &#160; &#160;&#160; 988,995</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(9) Aggregate amount beneficially owned by each reporting person</div>
            <div style="margin-left: 21.6pt; font-size: 12pt;">988,995</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(10) Check if the aggregate amount in Row (9) excludes certain shares</div>
            <div style="font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(11) Percent of class represented by amount in Row (9) 2.0%</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(12) Type of reporting person (see instructions) OO</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>

    </table>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="margin-bottom: 10pt;"><br>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z32586fe0217d4737912c204fc16f06e1">

        <tr>
          <td colspan="2" style="width: 100%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-align: center; font-size: 12pt;">CUSIP No. 74006W108</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(1) Names of reporting persons&#160; &#160; Steven A. Cohen</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(2) Check the appropriate box if a member of a group</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(a)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="text-indent: 176.2pt; font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(b)X</div>
          </td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(3) SEC use only</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(4) Citizenship or place of organization United States</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">Number of shares beneficially owned by each reporting person with:</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(5) Sole voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 0</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(6) Shared voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; 1,109,184</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(7) Sole dispositive power&#160; &#160; &#160; &#160; &#160;&#160; 0</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(8) Shared dispositive power&#160; &#160; &#160;&#160; 1,109,184</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(9) Aggregate amount beneficially owned by each reporting person</div>
            <div style="margin-left: 21.6pt; font-size: 12pt;">1,109,184</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(10) Check if the aggregate amount in Row (9) excludes certain shares</div>
            <div style="font-size: 12pt;">(see instructions)</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(11) Percent of class represented by amount in Row (9) 2.2%</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 93.37%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">
            <div style="font-size: 12pt;">(12) Type of reporting person (see instructions) IN</div>
          </td>
          <td style="width: 6.63%; vertical-align: top; border-left: #000000 2px solid; border-right: #000000 2px solid; border-top: #000000 2px solid; border-bottom: #000000 2px solid;">&#160;</td>
        </tr>

    </table>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="margin-bottom: 10pt;"><br>
    </div>
    <div>
      <div style="font-size: 12pt;">Item 1(a) Name of issuer:</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">Praxis Precision Medicines, Inc.</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">Item 1(b) Address of issuer's principal executive offices:</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">99 High Street, 30<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> Floor, Boston, MA 02110</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">2(a) Name of persons filing (the &#8220;Reporting Persons&#8221;):</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">This statement is filed by: (i) Point72 Asset Management, L.P. (&#8220;Point72 Asset Management&#8221;)<br>
        with respect to 100,000 shares of common stock, par value $0.0001 per share (&#8220;Common<br>
        Stock&#8221;), of the Issuer held by an investment fund it manages; (ii) Point72 Capital Advisors, Inc.<br>
        (&#8220;Point72 Capital Advisors Inc.&#8221;) with respect to shares of Common Stock held by an investment<br>
        fund managed by Point72 Asset Management; (iii) Cubist Systematic Strategies, LLC (&#8220;Cubist<br>
        Systematic Strategies&#8221;) with respect to 17,920 shares of Common Stock held by an investment<br>
        fund it manages; (iv) Point72 Middle East FZE (&#8220;Point72 Middle East&#8221;) with respect to 2,269<br>
        shares of Common Stock held by an investment fund it manages; (v) Point72 Biotech Private<br>
        Investments, LLC (&#8220;Point72 Biotech&#8221;) with respect to 988,995 shares of Common Stock of<br>
        which it is the holder; (vi) Differentiated Ventures Investments, LLC (&#8220;Differentiated<br>
        Ventures&#8221;), the managing member of Point72 Biotech, with respect to the shares of Common<br>
        Stock held by Point72 Biotech; (vii) 72 Investment Holdings, LLC (&#8220;72 Investment Holdings&#8221;),<br>
        the sole member of Differentiated Ventures, with respect to the shares of Common Stock held by<br>
        Point72 Biotech, and (viii) Steven A. Cohen (&#8220;Mr. Cohen&#8221;) the sole member of 72 Investment<br>
        Holdings and sole shareholder of Point72 Capital Advisors Inc., with respect to: (A) the 100,000<br>
        shares of Common Stock beneficially owned by Point72 Asset Management and Point72 Capital<br>
        Advisors Inc., (B) the 17,920 shares of Common Stock beneficially owned by Cubist System<br>
        Strategies, (C) the 2,269 shares of Common Stock beneficially owned by Point72 Middle East<br>
        and (D) the 988,995 shares of Common Stock beneficially owned Point72 Biotech,<br>
        Differentiated Ventures, and 72 Investment Holdings.</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">Point72 Asset Management, Point72 Capital Advisors Inc., Cubist Systematic Strategies, Point72<br>
        Hong Kong, Point72 Middle East, Point72 Biotech, Differentiated Investors, 72 Investment<br>
        Holdings, and Mr. Cohen have entered into a Joint Filing Agreement, a copy of which is filed<br>
        with this Schedule 13G as Exhibit 99.1, pursuant to which they have agreed to file this Schedule<br>
        13G jointly in accordance with the provisions of Rule 13d-1(k) of the Act.</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">2(b) Address or principal business office or, if none, residence:</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">The address of the principal business office of (i) Point72 Asset Management, Point72 Capital<br>
        Advisors Inc., Point72 Biotech, Differentiated Ventures, 72 Investment Holdings, and Mr. Cohen<br>
        is 72 Cummings Point Road, Stamford, CT 06902; (ii) Cubist Systematic Strategies is 55 Hudson<br>
        Yards, New York, NY 10001; (iii) Point72 Hong Kong is Suites 1102 -1110, 11th Floor and 12th<br>
        Floor, Chater House, 8 Connaught Road Central, Hong Kong; and (iv) Point72 Middle East is<br>
        EO3, 04, Sheikh Rashid Tower, Dubai World Trade Centre, Dubai, United Arab Emirates.</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div class="BRPFPageBreak" style="page-break-after:always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">2(c) Citizenship:</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">Point72 Asset Management is a Delaware limited partnership. Point72 Capital Advisors Inc. is a<br>
        Delaware corporation. Cubist Systematic Strategies, Point72 Biotech, Differentiated Ventures,<br>
        and 72 Investment Holdings are Delaware limited liability companies. Point72 Hong Kong is a<br>
        Hong Kong limited liability company. Point72 Middle East is a limited liability free zone<br>
        establishment.&#160;&#160; Mr. Cohen is a United States citizen.</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">2(d) Title of class of securities:</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">Common Stock, par value $0.0001 per share</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">2(e) CUSIP Number:</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">74006W108</div>
    </div>
    <div>
      <div><br>
      </div>
    </div>
    <div style="font-size: 12pt; font-style: italic;">Item 3.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">Not applicable</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;"><font style="font-style: italic;">Item 4. </font>Ownership</div>
    <div><br>
    </div>
    <div>
      <div style="font-size: 12pt;">The information required by Items 4(a) &#8211; (c) is set forth in Rows (5) &#8211; (11) of the cover page for<br>
        each Reporting Person hereto and is incorporated herein by reference for each Reporting Person.<br>
        Such information is as of the close of business on December 31, 2022.</div>
    </div>
    <div><br>
    </div>
    <div>
      <div style="font-size: 12pt;">Point72 Asset Management is the manager to a private investment fund that is the holder of<br>
        100,000 shares of Common Stock.&#160; Pursuant to an investment management agreement, Point72<br>
        Asset Management maintains investment and voting power with respect to securities held by<br>
        such private investment fund and, as a result, may be deemed to share beneficial ownership over<br>
        the 100,000 shares of Common Stock held by such fund.&#160; Point72 Capital Advisors, Inc. is the<br>
        general partner of Point72 Asset Management and may be deemed to share beneficial ownership<br>
        of the shares of Common Stock of which Point72 Asset Management may be deemed the<br>
        beneficial owner.</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">Cubist Systematic Strategies is the manager to a private investment fund that is the holder of<br>
        17,920 shares of Common Stock.&#160;&#160; Pursuant to an investment management agreement, Cubist<br>
        Systematic Strategies maintains investment and voting power with respect to securities held by<br>
        such private investment fund and, as a result, may be deemed to share beneficial ownership over<br>
        the 17,920 shares of Common Stock held by such fund.</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">Point72 Middle East is the manager to a private investment fund that is the holder of 2,269<br>
        shares of Common Stock.&#160;&#160; Pursuant to an investment management agreement, Point72 Middle<br>
        East maintains investment and voting power with respect to securities held by such private<br>
        investment fund and, as a result, may be deemed to share beneficial ownership over the 2,269<br>
        shares of Common Stock held by such fund.</div>
      <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
        <div class="BRPFPageBreak" style="page-break-after:always;">
          <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
      </div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">Point72 Biotech is the holder of 988,995 shares of Common Stock.&#160; Differentiated Ventures is<br>
        the managing member of Point72 Biotech and may be deemed to share beneficial ownership over<br>
        the shares of Common Stock held by Point72 Biotech.&#160; 72 Investment Holdings is the sole<br>
        member of Differentiated Ventures and may be deemed to share beneficial ownership of the<br>
        shares of Common Stock of which Differentiated Ventures may be deemed the beneficial owner.</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">Mr. Cohen is the sole member of 72 Investment Holdings and sole shareholder of Point72<br>
        Capital Advisors Inc. and may be deemed to beneficially own both the 988,995 shares of<br>
        Common Stock of which 72 Investment Holdings may be deemed the beneficial owner and the<br>
        100,000 shares of Common Stock of which Point72 Capital Advisors Inc. may be deemed the<br>
        beneficial owner.</div>
      <div><br>
      </div>
      <div style="font-size: 12pt;">The filing of this statement should not be construed as an admission that any of the foregoing<br>
        persons or any reporting person is, for the purposes of Section 13 of the Act, the beneficial<br>
        owner of the Common Stock reported herein.</div>
      <div><br>
      </div>
    </div>
    <div style="font-size: 12pt;"><font style="font-style: italic;">Item 5.&#160; </font>Ownership of 5 Percent or Less of a Class.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">If this statement is being filed to report the fact that as of the date hereof the reporting person has<br>
      ceased to be the beneficial owner of more than 5 percent of the class of securities, check the<br>
      following [X].</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;"><font style="font-style: italic;">Item 6.</font>&#160; Ownership of More than 5 Percent on Behalf of Another Person.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">See Item 2(a)</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;"><font style="font-style: italic;">Item 7.</font>&#160; Identification and Classification of the Subsidiary Which Acquired the Security Being<br>
      Reporting on by the Parent Holding Company or Control Person.</div>
    <div>
      <div style="font-size: 12pt;">Not applicable</div>
      <div style="font-size: 12pt;"><font style="font-style: italic;">Item 8. </font>Identification and Classification of Members of the Group</div>
    </div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">Not applicable</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;"><font style="font-style: italic;">Item 9.</font>&#160; Notice of Dissolution of Group.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">Not applicable</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;"><font style="font-style: italic;">Item 10. </font>Certifications</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">By signing below I certify that, to the best of my knowledge and belief, the securities referred to </div>
    <div style="font-size: 12pt;">above were not acquired and are not held for the purpose of or with the effect of changing or </div>
    <div style="font-size: 12pt;">influencing the control of the issuer of the securities and were not acquired and are not held in </div>
    <div style="font-size: 12pt;">connection with or as a participant in any transaction having that purpose or effect.</div>
    <div class="BRPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div class="BRPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div><br>
    </div>
    <div style="font-size: 12pt;"><font style="font-style: italic;">Signature.</font>&#160; After reasonable inquiry and to the best of my knowledge and belief, I certify </div>
    <div style="font-size: 12pt;">that the information set forth in this statement is true, complete and correct.</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div>
      <div style="font-size: 12pt;">Dated: <u>February 14, 2023</u></div>
      <div><br>
      </div>
      <div><br>
      </div>
    </div>
    <div style="font-size: 12pt;">POINT72 ASSET MANAGEMENT, L.P.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">By: <u>/s/ Jason M. Colombo</u><br>
      Name: Jason M. Colombo<br>
      Title: Authorized Person</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">POINT72 CAPITAL ADVISORS, INC.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">By: <u>/s/ Jason M. Colombo</u><br>
      Name: Jason M. Colombo<br>
      Title: Authorized Person</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">CUBIST SYSTEMATIC STRATEGIES, LLC</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">By: <u>/s/ Jason M. Colombo</u><br>
      Name: Jason M. Colombo<br>
      Title: Authorized Person</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">POINT72 HONG KONG LIMITED</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">By: <u>/s/ Jason M. Colombo</u><br>
      Name: Jason M. Colombo<br>
      Title: Authorized Person</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">POINT72 MIDDLE EAST FZE</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">By: <u>/s/ Rafael Lopez Espinosa</u><br>
      Name: Rafael Lopez Espinosa<br>
      Title: Authorized Person</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">POINT72 BIOTECH PRIVATE INVESTMENTS, LLC</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">By: <u>/s/ Vincent Tortorella</u><br>
      Name: Vincent Tortorella<br>
      Title: Authorized Person</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">DIFFERENTIATED VENTURES INVESTMENTS, LLC</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">By: <u>/s/ Vincent Tortorella</u><br>
      Name: Vincent Tortorella<br>
      Title: Authorized Person</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">72 INVESTMENT HOLDINGS, LLC</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">By: <u>/s/ Jason M. Colombo</u><br>
      Name: Jason M. Colombo<br>
      Title: Authorized Person</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">STEVEN A. COHEN</div>
    <div><br>
    </div>
    <div style="margin-bottom: 10pt; font-size: 12pt;">By: <u>/s/ Jason M. Colombo</u><br>
      Name: Jason M. Colombo<br>
      Title: Authorized Person</div>
  </div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>pt7213gab.htm
<DESCRIPTION>JOINT FILING AGREEMENT
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: Willkie Farr & Gallagher
         Document created using Broadridge PROfile 23.1.1.5115
         Copyright 1995 - 2023 Broadridge -->
  </head>
<body bgcolor="#ffffff" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;">
  <div>
    <div style="font-size: 12pt;">Exhibit 99.1</div>
    <div style="text-align: center; font-size: 12pt;">JOINT FILING AGREEMENT</div>
    <div style="margin-bottom: 10pt;"><br>
    </div>
    <div style="margin-bottom: 10pt; font-size: 12pt;">The undersigned hereby agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned in accordance
      with the provisions of Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, and that all subsequent amendments to this statement on Schedule 13G may be filed on behalf of each of the undersigned without the necessity of filing
      additional joint filing agreements. &#160;</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div>
      <div style="font-size: 12pt;">Dated: <u>February 14, 2023</u></div>
      <div><br>
      </div>
      <div><br>
      </div>
    </div>
    <div style="font-size: 12pt;">POINT72 ASSET MANAGEMENT, L.P.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">By: <u>/s/ Jason M. Colombo</u><br>
      Name: Jason M. Colombo<br>
      Title: Authorized Person</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">POINT72 CAPITAL ADVISORS, INC.</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">By: <u>/s/ Jason M. Colombo</u><br>
      Name: Jason M. Colombo<br>
      Title: Authorized Person</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">CUBIST SYSTEMATIC STRATEGIES, LLC</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">By: <u>/s/ Jason M. Colombo</u><br>
      Name: Jason M. Colombo<br>
      Title: Authorized Person</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">POINT72 HONG KONG LIMITED</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">By: <u>/s/ Jason M. Colombo</u><br>
      Name: Jason M. Colombo<br>
      Title: Authorized Person</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">POINT72 MIDDLE EAST FZE</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">By: <u>/s/ Rafael Lopez Espinosa</u><br>
      Name: Rafael Lopez Espinosa<br>
      Title: Authorized Person</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">POINT72 BIOTECH PRIVATE INVESTMENTS, LLC</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">By: <u>/s/ Vincent Tortorella</u><br>
      Name: Vincent Tortorella<br>
      Title: Authorized Person</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">DIFFERENTIATED VENTURES INVESTMENTS, LLC</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">By: <u>/s/ Vincent Tortorella</u><br>
      Name: Vincent Tortorella<br>
      Title: Authorized Person</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">72 INVESTMENT HOLDINGS, LLC</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">By: <u>/s/ Jason M. Colombo</u><br>
      Name: Jason M. Colombo<br>
      Title: Authorized Person</div>
    <div><br>
    </div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">STEVEN A. COHEN</div>
    <div><br>
    </div>
    <div>
      <div style="font-size: 12pt;">By: <u>/s/ Jason M. Colombo</u><br>
        Name: Jason M. Colombo<br>
        Title: Authorized Person</div>
    </div>
  </div>
</body>
</html>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
