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Condensed Consolidated Statements of Stockholders’ Equity (Unaudited) - USD ($)
$ in Thousands
Total
Follow-On Offering
At-The-Market Offering
License And Collaboration Agreement
Common Stock
Common Stock
Follow-On Offering
Common Stock
At-The-Market Offering
Common Stock
License And Collaboration Agreement
Additional Paid-In Capital
Additional Paid-In Capital
Follow-On Offering
Additional Paid-In Capital
At-The-Market Offering
Additional Paid-In Capital
License And Collaboration Agreement
Accumulated Deficit
Accumulated Other Comprehensive Income (Loss)
Beginning balance (in shares) at Dec. 31, 2022 [1]         3,292,163                  
Beginning balance at Dec. 31, 2022 $ 76,106       $ 5 [1]       $ 606,918       $ (530,644) $ (173)
Increase (Decrease) in Stockholders' Equity [Roll Forward]                            
Stock-based compensation expense 7,593               7,593          
Issuance of common stock (in shares) [1]         560,253                  
Issuance of common stock 18,096       $ 1 [1]       18,095          
Vesting of restricted stock awards (in shares) [1]         11,516                  
Shares withheld for taxes for vesting of restricted stock units (in shares) [1]         (2,875)                  
Shares withheld for taxes for vesting of restricted stock units (127)               (127)          
Issuance of common stock upon exercise of stock options (in shares) [1]         2,970                  
Issuance of common stock upon exercise of stock options 101               101          
Change in unrealized gain on marketable securities, net of tax 154                         154
Net loss (37,455)                       (37,455)  
Ending balance (in shares) at Mar. 31, 2023 [1]         3,864,027                  
Ending balance at Mar. 31, 2023 64,468       $ 6 [1]       632,580       (568,099) (19)
Beginning balance (in shares) at Dec. 31, 2022 [1]         3,292,163                  
Beginning balance at Dec. 31, 2022 76,106       $ 5 [1]       606,918       (530,644) (173)
Increase (Decrease) in Stockholders' Equity [Roll Forward]                            
Change in unrealized gain on marketable securities, net of tax 173                          
Net loss (96,399)                          
Ending balance (in shares) at Sep. 30, 2023 [1]         8,569,822                  
Ending balance at Sep. 30, 2023 86,756       $ 13 [1]       713,786       (627,043) 0
Beginning balance (in shares) at Mar. 31, 2023 [1]         3,864,027                  
Beginning balance at Mar. 31, 2023 64,468       $ 6 [1]       632,580       (568,099) (19)
Increase (Decrease) in Stockholders' Equity [Roll Forward]                            
Stock-based compensation expense 5,775               5,775          
Issuance of common stock (in shares) [1]           4,296,646 392,541              
Issuance of common stock   $ 63,439 $ 6,032     $ 6 [1] $ 1 [1]     $ 63,433 $ 6,031      
Issuance of common stock under employee stock purchase plan (in shares) [1]         15,663                  
Issuance of common stock under employee stock purchase plan 208               208          
Vesting of restricted stock awards (in shares) [1]         720                  
Shares withheld for taxes for vesting of restricted stock units (in shares) [1]         (249)                  
Shares withheld for taxes for vesting of restricted stock units (4)               (4)          
Change in unrealized gain on marketable securities, net of tax 19                         19
Net loss (34,312)                       (34,312)  
Ending balance (in shares) at Jun. 30, 2023 [1]         8,569,348                  
Ending balance at Jun. 30, 2023 105,625       $ 13 [1]       708,023       (602,411) 0
Increase (Decrease) in Stockholders' Equity [Roll Forward]                            
Stock-based compensation expense 5,763               5,763          
Vesting of restricted stock awards (in shares) [1]         233                  
Shares withheld for taxes for vesting of restricted stock units (in shares) [1]         (70)                  
Shares withheld for taxes for vesting of restricted stock units (1)               (1)          
Issuance of common stock upon exercise of stock options (in shares) [1]         311                  
Issuance of common stock upon exercise of stock options 1               1          
Change in unrealized gain on marketable securities, net of tax 0                          
Net loss (24,632)                       (24,632)  
Ending balance (in shares) at Sep. 30, 2023 [1]         8,569,822                  
Ending balance at Sep. 30, 2023 $ 86,756       $ 13 [1]       713,786       (627,043) 0
Beginning balance (in shares) at Dec. 31, 2023 8,791,877       8,791,877                  
Beginning balance at Dec. 31, 2023 $ 69,669       $ 13       723,577       (653,921) 0
Increase (Decrease) in Stockholders' Equity [Roll Forward]                            
Stock-based compensation expense 14,475               14,475          
Issuance of common stock (in shares)           3,802,025 209,852 443,253            
Issuance of common stock   161,649 $ 6,169 $ 17,265           161,649 $ 6,169 $ 17,265    
Vesting of restricted stock awards (in shares)         11,095                  
Shares withheld for taxes for vesting of restricted stock units (in shares)         (3,689)                  
Shares withheld for taxes for vesting of restricted stock units (137)               (137)          
Issuance of common stock upon exercise of stock options (in shares)         3,634                  
Issuance of common stock upon exercise of stock options 143               143          
Change in unrealized gain on marketable securities, net of tax 3                         3
Net loss (39,553)                       (39,553)  
Ending balance (in shares) at Mar. 31, 2024         13,258,047                  
Ending balance at Mar. 31, 2024 $ 229,683       $ 13       923,141       (693,474) 3
Beginning balance (in shares) at Dec. 31, 2023 8,791,877       8,791,877                  
Beginning balance at Dec. 31, 2023 $ 69,669       $ 13       723,577       (653,921) 0
Increase (Decrease) in Stockholders' Equity [Roll Forward]                            
Issuance of common stock upon exercise of stock options (in shares) 8,753                          
Change in unrealized gain on marketable securities, net of tax $ 1,331                          
Net loss $ (124,140)                          
Ending balance (in shares) at Sep. 30, 2024 17,785,697       17,785,697                  
Ending balance at Sep. 30, 2024 $ 382,666       $ 14       1,159,382       (778,061) 1,331
Beginning balance (in shares) at Mar. 31, 2024         13,258,047                  
Beginning balance at Mar. 31, 2024 229,683       $ 13       923,141       (693,474) 3
Increase (Decrease) in Stockholders' Equity [Roll Forward]                            
Stock-based compensation expense $ 5,878               5,878          
Issuance of common stock (in shares)           3,849,558                
Issuance of common stock   215,988       $ 1       215,987        
Issuance of common stock from exercise of pre-funded warrants (in shares) 622,123                          
Issuance of common stock under employee stock purchase plan (in shares)         25,146                  
Issuance of common stock under employee stock purchase plan $ 311               311          
Vesting of restricted stock awards (in shares)         726                  
Shares withheld for taxes for vesting of restricted stock units (in shares)         (242)                  
Shares withheld for taxes for vesting of restricted stock units (13)               (13)          
Issuance of common stock upon exercise of stock options (in shares)         148                  
Issuance of common stock upon exercise of stock options 4               4          
Change in unrealized gain on marketable securities, net of tax (74)                         (74)
Net loss (32,677)                       (32,677)  
Ending balance (in shares) at Jun. 30, 2024         17,755,506                  
Ending balance at Jun. 30, 2024 419,100       $ 14       1,145,308       (726,151) (71)
Increase (Decrease) in Stockholders' Equity [Roll Forward]                            
Stock-based compensation expense 12,432               12,432          
Issuance of common stock (in shares)           25,189                
Issuance of common stock   $ 1,442               $ 1,442        
Vesting of restricted stock awards (in shares)         51                  
Shares withheld for taxes for vesting of restricted stock units (in shares)         (20)                  
Shares withheld for taxes for vesting of restricted stock units (1)               (1)          
Issuance of common stock upon exercise of stock options (in shares)         4,971                  
Issuance of common stock upon exercise of stock options 201               201          
Change in unrealized gain on marketable securities, net of tax 1,402                         1,402
Net loss $ (51,910)                       (51,910)  
Ending balance (in shares) at Sep. 30, 2024 17,785,697       17,785,697                  
Ending balance at Sep. 30, 2024 $ 382,666       $ 14       $ 1,159,382       $ (778,061) $ 1,331
[1] Results have been retroactively adjusted to reflect the 1-for-15 reverse stock split effected on November 28, 2023. See Note 2 for details.