<SEC-DOCUMENT>0001415889-25-004233.txt : 20250214
<SEC-HEADER>0001415889-25-004233.hdr.sgml : 20250214
<ACCEPTANCE-DATETIME>20250214180838
ACCESSION NUMBER:		0001415889-25-004233
CONFORMED SUBMISSION TYPE:	SCHEDULE 13G/A
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20250214
DATE AS OF CHANGE:		20250214

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Praxis Precision Medicines, Inc.
		CENTRAL INDEX KEY:			0001689548
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-92098
		FILM NUMBER:		25631555

	BUSINESS ADDRESS:	
		STREET 1:		99 HIGH STREET, 30TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110
		BUSINESS PHONE:		617-300-8460

	MAIL ADDRESS:	
		STREET 1:		99 HIGH STREET, 30TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02110

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Venrock Healthcare Capital Partners III, L.P.
		CENTRAL INDEX KEY:			0001738048
		ORGANIZATION NAME:           	
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		530 FIFTH AVENUE, 22ND FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10036
		BUSINESS PHONE:		212-444-4100

	MAIL ADDRESS:	
		STREET 1:		530 FIFTH AVENUE, 22ND FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10036
</SEC-HEADER>
<DOCUMENT>
<TYPE>SCHEDULE 13G/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
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		<previousAccessionNumber>0001104659-23-077120</previousAccessionNumber>
	    <filerInfo>
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    <coverPageHeader>
		<amendmentNo>3</amendmentNo>
	      <securitiesClassTitle>Common Stock, par value $0.0001 per share </securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>12/31/2024</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001689548</issuerCik>        <issuerName>Praxis Precision Medicines, Inc. </issuerName>        <issuerCusip>74006W207</issuerCusip>
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          <com:street1>99 High Street, 30th Floor</com:street1>
                    <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02110</com:zipCode>
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	   				        <designateRulePursuantThisScheduleFiled>Rule 13d-1(c)</designateRulePursuantThisScheduleFiled>
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                         <sharedDispositivePower>1190340.00</sharedDispositivePower>
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    <reportingPersonName>VHCP Co-Investment Holdings III, LLC</reportingPersonName>

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	    <coverPageHeaderReportingPersonDetails>




    <reportingPersonName>Venrock Healthcare Capital Partners EG, L.P.</reportingPersonName>

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		 <citizenshipOrOrganization>DE</citizenshipOrOrganization>

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                <soleVotingPower>0.00</soleVotingPower>
                          <sharedVotingPower>1190340.00</sharedVotingPower>
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                         <sharedDispositivePower>1190340.00</sharedDispositivePower>
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    <reportingPersonName>VHCP Management III, LLC</reportingPersonName>

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		 <citizenshipOrOrganization>DE</citizenshipOrOrganization>

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                          <sharedVotingPower>1190340.00</sharedVotingPower>
                          <soleDispositivePower>0.00</soleDispositivePower>
                         <sharedDispositivePower>1190340.00</sharedDispositivePower>
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	        <typeOfReportingPerson>OO</typeOfReportingPerson>



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	    <coverPageHeaderReportingPersonDetails>




    <reportingPersonName>VHCP Management EG, LLC</reportingPersonName>

	  		<memberGroup>a</memberGroup>


		 <citizenshipOrOrganization>DE</citizenshipOrOrganization>

      <reportingPersonBeneficiallyOwnedNumberOfShares>
                <soleVotingPower>0.00</soleVotingPower>
                          <sharedVotingPower>1190340.00</sharedVotingPower>
                          <soleDispositivePower>0.00</soleDispositivePower>
                         <sharedDispositivePower>1190340.00</sharedDispositivePower>
             </reportingPersonBeneficiallyOwnedNumberOfShares>

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	    <coverPageHeaderReportingPersonDetails>




    <reportingPersonName>Nimish Shah</reportingPersonName>

	  		<memberGroup>a</memberGroup>


		 <citizenshipOrOrganization>X1</citizenshipOrOrganization>

      <reportingPersonBeneficiallyOwnedNumberOfShares>
                <soleVotingPower>0.00</soleVotingPower>
                          <sharedVotingPower>1190340.00</sharedVotingPower>
                          <soleDispositivePower>0.00</soleDispositivePower>
                         <sharedDispositivePower>1190340.00</sharedDispositivePower>
             </reportingPersonBeneficiallyOwnedNumberOfShares>

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	        <typeOfReportingPerson>IN</typeOfReportingPerson>




    </coverPageHeaderReportingPersonDetails>
	    <coverPageHeaderReportingPersonDetails>




    <reportingPersonName>Bong Y Koh</reportingPersonName>

	  		<memberGroup>a</memberGroup>


		 <citizenshipOrOrganization>X1</citizenshipOrOrganization>

      <reportingPersonBeneficiallyOwnedNumberOfShares>
                <soleVotingPower>0.00</soleVotingPower>
                          <sharedVotingPower>1190340.00</sharedVotingPower>
                          <soleDispositivePower>0.00</soleDispositivePower>
                         <sharedDispositivePower>1190340.00</sharedDispositivePower>
             </reportingPersonBeneficiallyOwnedNumberOfShares>

              <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>1190340.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>


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	        <typeOfReportingPerson>IN</typeOfReportingPerson>




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    <items>
      <item1>
        <issuerName>Praxis Precision Medicines, Inc. </issuerName>
        <issuerPrincipalExecutiveOfficeAddress>99 High Street, 30th Floor, Boston, MA, 02110.</issuerPrincipalExecutiveOfficeAddress>
      </item1>

      <item2>
        <filingPersonName>The names of the persons filing this report (collectively, the "Reporting Persons") are:

Venrock Healthcare Capital Partners III, L.P. ("VHCP III")
VHCP Co-Investment Holdings III, LLC ("VHCP Co-Investment III")
Venrock Healthcare Capital Partners EG, L.P. ("VHCP EG")
VHCP Management III, LLC ("VHCP Management III")
VHCP Management EG, LLC ("VHCP Management EG")
Nimish Shah ("Shah")
Bong Koh ("Koh")

The Reporting Persons are members of a group for the purposes of this Schedule 13G.
</filingPersonName>        <principalBusinessOfficeOrResidenceAddress>New York Office:
7 Bryant Park, 23rd Floor
New York, NY 10018

Palo Alto Office:
3340 Hillview Avenue
Palo Alto, CA 94304
</principalBusinessOfficeOrResidenceAddress>        <citizenship>All of the entities were organized in Delaware. Shah and Koh are both United States citizens.</citizenship>      </item2>

        <item3>
		        <notApplicableFlag>Y</notApplicableFlag>

      </item3>



    <item4>
    <amountBeneficiallyOwned>Row 9 of each Reporting Person's cover page to this Schedule 13G sets forth the aggregate number of shares of securities of the Issuer beneficially owned by such Reporting Person as of December 31, 2024 and is incorporated by reference.

The Reporting Persons' ownership of the Issuer's securities consists of (i) 241,337 shares of Common stock and warrants (the "Warrants") exercisable for up to 52,670 shares of Common Stock held by VHCP III, (ii) 24,132 shares of Common Stock and Warrants exercisable for up to 5,270 shares of Common Stock held by VHCP Co-Investment III, and (iii) 724,516 shares of Common Stock and Warrants exercisable for up to 142,415 shares of Common Stock held by VHCP EG.

VHCP Management III is the general partner of VHCP III and the manager of VHCP Co-Investment III. VHCP Management EG is the general partner of VHCP EG. Messrs. Shah and Koh are the voting members of VHCP Management III and VHCP Management EG.</amountBeneficiallyOwned>    <classPercent>Row 11 of each Reporting Person's cover page to this Schedule 13G sets forth the percentages of the shares of securities of the Issuer beneficially owned by such Reporting Person as of December 31, 2024 and is incorporated by reference. The percentage set forth in Row 11 of each Reporting Person's cover page is based upon the sum of (i) 19,248,853 shares of Common Stock outstanding as of November 30, 2024 as disclosed in the Issuer's Registration Statement on Form S-3 filed with the Securities and Exchange Commission (the "SEC") on December 23, 2024, and (ii) 200,355 shares of Common Stock issuable upon the exercise of Warrants.</classPercent>
      <numberOfSharesPersonHas>
        <solePowerOrDirectToVote>Row 5 of each Reporting Person's cover page to this Schedule 13G sets forth the sole power to vote or to direct the vote of securities of the Issuer beneficially owned by such Reporting Person as of December 31, 2024 and is incorporated by reference.</solePowerOrDirectToVote>
        <sharedPowerOrDirectToVote>Row 6 of each Reporting Person's cover page to this Schedule 13G sets forth the shared power to vote or to direct the vote of securities of the Issuer beneficially owned by such Reporting Person as of December 31, 2024 and is incorporated by reference.</sharedPowerOrDirectToVote>
        <solePowerOrDirectToDispose>Row 7 of each Reporting Person's cover page to this Schedule 13G sets forth the sole power to dispose or to direct the disposition of securities of the Issuer beneficially owned by such Reporting Person as of December 31, 2024 and is incorporated by reference.</solePowerOrDirectToDispose>
        <sharedPowerOrDirectToDispose>Row 8 of each Reporting Person's cover page to this Schedule 13G sets forth the shared power to dispose or to direct the disposition of securities of the Issuer beneficially owned by such Reporting Person as of December 31, 2024 and is incorporated by reference.</sharedPowerOrDirectToDispose>
      </numberOfSharesPersonHas>
    </item4>


        <item5>
	          <notApplicableFlag>Y</notApplicableFlag>


    </item5>


        <item6>
	  	  <notApplicableFlag>Y</notApplicableFlag>
		        </item6>


        <item7>
	  	  <notApplicableFlag>Y</notApplicableFlag>


    </item7>


          <item8>
                <notApplicableFlag>Y</notApplicableFlag>

              </item8>


            <item9>
                <notApplicableFlag>Y</notApplicableFlag>
                      </item9>


      <item10>
                <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.</certifications>

      </item10>
    </items>

		<exhibitInfo>Exhibit 24.1	Power of Attorney for Nimish Shah (incorporated by reference to Exhibit B to Schedule 13G filed on July 24, 2023)

Exhibit 24.2	Power of Attorney for Bong Koh (incorporated by reference to Exhibit C to Schedule 13G filed on July 24, 2023)

Exhibit 99.1	Joint Filing Agreement</exhibitInfo>

	    <signatureInformation>
      <reportingPersonName>Venrock Healthcare Capital Partners III, L.P.</reportingPersonName>

      <signatureDetails>
        <signature>/s/ Sherman G. Souther</signature>
        <title>By VHCP Management III, LLC, its General Partner, By Sherman G. Souther, Authorized Signatory</title>
        <date>02/14/2025</date>
      </signatureDetails>

    </signatureInformation>
	     <signatureInformation>
      <reportingPersonName>VHCP Co-Investment Holdings III, LLC</reportingPersonName>

      <signatureDetails>
        <signature>/s/ Sherman G. Souther</signature>
        <title>By VHCP Management III, LLC, its Manager, By Sherman G. Souther, Authorized Signatory</title>
        <date>02/14/2025</date>
      </signatureDetails>

    </signatureInformation>
	     <signatureInformation>
      <reportingPersonName>Venrock Healthcare Capital Partners EG, L.P.</reportingPersonName>

      <signatureDetails>
        <signature>/s/ Sherman G. Souther</signature>
        <title>By VHCP Management EG, LLC, its General Partner, By Sherman G. Souther, Authorized Signatory</title>
        <date>02/14/2025</date>
      </signatureDetails>

    </signatureInformation>
	     <signatureInformation>
      <reportingPersonName>VHCP Management III, LLC</reportingPersonName>

      <signatureDetails>
        <signature>/s/ Sherman G. Souther</signature>
        <title>By Sherman G. Souther, Authorized Signatory</title>
        <date>02/14/2025</date>
      </signatureDetails>

    </signatureInformation>
	     <signatureInformation>
      <reportingPersonName>VHCP Management EG, LLC</reportingPersonName>

      <signatureDetails>
        <signature>/s/ Sherman G. Souther</signature>
        <title>By Sherman G. Souther, Authorized Signatory</title>
        <date>02/14/2025</date>
      </signatureDetails>

    </signatureInformation>
	     <signatureInformation>
      <reportingPersonName>Nimish Shah</reportingPersonName>

      <signatureDetails>
        <signature>/s/ Sherman G. Souther</signature>
        <title>By Sherman G. Souther, Attorney-in-fact</title>
        <date>02/14/2025</date>
      </signatureDetails>

    </signatureInformation>
	     <signatureInformation>
      <reportingPersonName>Bong Y Koh</reportingPersonName>

      <signatureDetails>
        <signature>/s/ Sherman G. Souther</signature>
        <title>By Sherman G. Souther, Attorney-in-fact</title>
        <date>02/14/2025</date>
      </signatureDetails>

    </signatureInformation>



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<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>ex-99-02142025_110241.htm
<DESCRIPTION>JOINT FILING AGREEMENT
<TEXT>
<!DOCTYPE html PUBLIC "-//IETF//DTD HTML//EN">
<html><head><title>ex-99-02142025_110241.htm</title></head><body style="margin-top:0;font-family:Times New Roman; font-size:10pt; color:#000000">
<p style="margin-top:0px; margin-bottom:16px" align="center"><b>EXHIBIT 99.1 </b></p>
<p style="margin-top:0px; margin-bottom:16px" align="center">JOINT FILING AGREEMENT</p>
<p style="margin-top:0px; margin-bottom:16px" align="justify">In accordance with Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, the undersigned agree to the joint filing on behalf of each of them of a statement on Schedule 13G (including amendments thereto) with respect to the Common Stock of Praxis Precision Medicines, Inc. and further agree that this agreement be included as an exhibit to such filing. Each party to the agreement expressly authorizes each other party to file on its behalf any and all amendments to such statement. Each party to this agreement agrees that this joint filing agreement may be signed in counterparts.</p>
<p style="margin-top:0px; margin-bottom:16px" align="justify">In evidence whereof, the undersigned have caused this Agreement to be executed on their behalf this 14<sup>th</sup> day of February, 2025.</p>
<table style="margin-top:0px; font-size:10pt" cellpadding="0" cellspacing="0" align="center"><tr style="font-size:0"><td width="314.667"></td><td width="309.333"></td></tr><tr><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="314.667" height="123"><p style="margin:0px"><b>Venrock Healthcare Capital Partners III, L.P.</b></p>
<p style="margin:0px"><br></p>
<p style="margin-top:0px; margin-bottom:-2px; width:36px; float:left">By:</p>
<p style="margin:0px; text-indent:-2px">VHCP Management III, LLC</p>
<p style="margin-top:0px; margin-bottom:-2px; width:36px; clear:left; float:left">Its:</p>
<p style="margin:0px; text-indent:-2px">General Partner</p>
<p style="margin:0px; clear:left"><br></p>
<p style="margin-top:0px; margin-bottom:-2px; width:36px; float:left">By:</p>
<p style="margin:0px; text-indent:-2px"><u>/s/ Sherman G. Souther</u></p>
<p style="margin:0px; text-indent:36px; clear:left">Name: Sherman G. Souther</p>
<p style="margin:0px; text-indent:36px">Its: Authorized Signatory</p>
<p style="margin:0px"><br></p>
<p style="margin:0px"><br></p>
</td><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="309.333" height="123"><p style="margin:0px"><b>Venrock Healthcare Capital Partners EG, L.P.</b></p>
<p style="margin:0px"><br></p>
<p style="margin-top:0px; margin-bottom:-2px; width:36px; float:left">By:</p>
<p style="margin:0px; text-indent:-2px">VHCP Management EG, LLC</p>
<p style="margin-top:0px; margin-bottom:-2px; width:36px; clear:left; float:left">Its:</p>
<p style="margin:0px; text-indent:-2px">General Partner</p>
<p style="margin:0px; clear:left"><br></p>
<p style="margin-top:0px; margin-bottom:-2px; width:36px; float:left">By: </p>
<p style="margin:0px; text-indent:-2px"><u>/s/ Sherman G. Souther</u></p>
<p style="margin:0px; text-indent:36px; clear:left">Name: Sherman G. Souther</p>
<p style="margin:0px; text-indent:36px">Its: Authorized Signatory</p>
<p style="margin:0px"><br></p>
</td></tr><tr><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="314.667"><p style="margin:0px"><b>VHCP Co-Investment Holdings III, LLC</b></p>
<p style="margin:0px"><br></p>
<p style="margin-top:0px; margin-bottom:-2px; width:36px; float:left">By:</p>
<p style="margin:0px; text-indent:-2px">VHCP Management III, LLC</p>
<p style="margin-top:0px; margin-bottom:-2px; width:36px; clear:left; float:left">Its:</p>
<p style="margin:0px; text-indent:-2px">Manager</p>
<p style="margin:0px; clear:left"><br></p>
<p style="margin-top:0px; margin-bottom:-2px; width:36px; float:left">By: </p>
<p style="margin:0px; text-indent:-2px"><u>/s/ Sherman G. Souther</u></p>
<p style="margin:0px; text-indent:36px; clear:left">Name: Sherman G. Souther</p>
<p style="margin:0px; text-indent:36px">Its: Authorized Signatory</p>
<p style="margin:0px"><br></p>
<p style="margin:0px"><br></p>
</td><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="309.333"><p style="margin:0px"><br></p>
</td></tr><tr><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="314.667"><p style="margin:0px"><b>VHCP Management III, LLC</b></p>
<p style="margin:0px"><br></p>
<p style="margin-top:0px; margin-bottom:-2px; width:36px; float:left">By: </p>
<p style="margin:0px; text-indent:-2px"><u>/s/ Sherman G. Souther</u></p>
<p style="margin:0px; text-indent:36px; clear:left">Name: Sherman G. Souther</p>
<p style="margin:0px; text-indent:36px">Its: Authorized Signatory</p>
<p style="margin:0px"><br></p>
<p style="margin:0px"><br></p>
</td><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="309.333"><p style="margin:0px"><b>VHCP Management EG, LLC</b></p>
<p style="margin:0px"><br></p>
<p style="margin-top:0px; margin-bottom:-2px; width:36px; float:left">By: </p>
<p style="margin:0px; text-indent:-2px"><u>/s/ Sherman G. Souther</u></p>
<p style="margin:0px; text-indent:36px; clear:left">Name: Sherman G. Souther</p>
<p style="margin:0px; text-indent:36px">Its: Authorized Signatory</p>
<p style="margin:0px"><br></p>
</td></tr><tr><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="314.667"><p style="margin:0px"><b>Nimish Shah</b></p>
<p style="margin:0px"><br></p>
<p style="margin:0px"><u>/s/ Sherman G. Souther</u></p>
<p style="margin:0px">Sherman G. Souther, Attorney-in-fact</p>
<p style="margin:0px"><br></p>
<p style="margin:0px"><br></p>
<p style="margin:0px"><b>Bong Koh</b></p>
<p style="margin:0px"><br></p>
<p style="margin:0px"><u>/s/ Sherman G. Souther</u></p>
<p style="margin:0px">Sherman G. Souther, Attorney-in-fact</p>
<p style="margin:0px"><br></p>
<p style="margin:0px"><br></p>
</td><td style="margin-top:0px; padding-left:4px; padding-top:0px; padding-right:4px; padding-bottom:0px" valign="top" width="309.333"><p style="margin:0px"><br></p>
</td></tr></table><p style="margin-top:0px; margin-bottom:16px"><br></p>
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