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Collaboration and Out-Licensing - Additional Information (Details) $ in Thousands, € in Millions |  | 1 Months Ended | 3 Months Ended | 6 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | --- | ---
Feb. 22, 2023 EUR (€) | Mar. 31, 2021 USD ($) | Nov. 30, 2020 USD ($) | Sep. 30, 2020 USD ($) | Sep. 30, 2020 EUR (€) | Jul. 31, 2020 USD ($) | Mar. 31, 2020 USD ($) | Jun. 30, 2023 USD ($) | Jun. 30, 2022 USD ($) | Jun. 30, 2023 USD ($) | Jun. 30, 2022 USD ($) | Dec. 31, 2021 USD ($) | Dec. 31, 2020 USD ($) | Dec. 31, 2020 EUR (€) | Dec. 31, 2022 USD ($)
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contract with Customer, Liability, Revenue Recognized |  |  |  |  |  |  |  |  |  | $ (30) |  |  |  |  |
Contract with Customer, Liability |  |  |  |  |  |  |  | $ 0 |  | 0 |  |  |  |  | $ 3,137
Alfresa Agreement [Member] | License Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront Payment. |  |  |  |  |  |  | $ 2,000 |  |  |  |  |  |  |  |
Milestone Payments |  |  |  |  |  |  | 13,000 |  |  |  |  |  |  |  |
Initial Transaction Price |  |  |  |  |  |  | 7,000 |  |  |  |  |  |  |  |
Contract with Customer, Liability, Revenue Recognized |  |  |  |  |  |  |  | 100 | $ 100 | 100 | $ 100 |  |  |  |
Contract with Customer, Liability |  |  |  |  |  |  |  | 0 |  | 0 |  |  |  |  |
Alfresa Agreement [Member] | License Agreement [Member] | JAPAN |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront Payment. |  |  |  |  |  |  | $ 2,000 |  |  |  |  |  |  |  |
License Agreement Expiration Term |  |  |  |  |  |  | 10 years |  |  |  |  |  |  |  |
Milestone Payments |  |  |  |  |  | $ 5,000 |  |  |  |  |  |  |  |  |
Recordati Agreement [Member] | License Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront Payment. |  |  |  |  |  |  |  |  |  |  |  |  | $ 11,800 |  |
Initial Transaction Price |  |  |  | $ 11,800 |  |  |  |  |  |  |  |  |  |  |
Regulatory Milestone Payment |  |  | $ 6,000 |  |  |  |  |  |  |  |  |  | $ 6,000 |  |
Regulatory and Commercial Sales Milestones | € |  |  |  |  |  |  |  |  |  |  |  |  |  | € 90.0 |
Recordati Agreement [Member] | Termination Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront Payment. | € | € 3.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contract with Customer, Liability, Revenue Recognized |  |  |  |  |  |  |  | $ 0 | $ 400 | $ 0 | $ 1,100 |  |  |  |
Recordati Agreement [Member] | Research and Development Expense [Member] | Termination Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront Payment. | € |  |  |  |  | € 3.0 |  |  |  |  |  |  |  |  |  |
Contract with Customer, Liability |  |  |  | $ 3,100 |  |  |  |  |  |  |  |  |  |  |
Recordati Agreement [Member] | European Medicines Agency [Member] | Termination Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone Payments | € | 2.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Recordati Agreement [Member] | First commercial sale of Recordati Licensed Product [Member] | Termination Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone Payments | € | 5.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Recordati Agreement [Member] | Aggregate sale of Recordati Licensed Product [Member] | Termination Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Royalty payments | € | € 5.0 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Pediatrix Agreement [Member] | License Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront Payment. |  | $ 3,000 |  |  |  |  |  |  |  |  |  |  |  |  |
License Agreement Expiration Term |  | 10 years |  |  |  |  |  |  |  |  |  |  |  |  |
Initial Transaction Price |  | $ 3,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Contract with Customer, Liability, Revenue Recognized |  |  |  |  |  |  |  |  |  |  |  | $ 3,000 |  |  |
Regulatory and Commercial Sales Milestones |  | $ 84,000 |  |  |  |  |  |  |  |  |  |  |  |  |

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