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STATEMENTS OF OPERATIONS - USD ($) | 9 Months Ended | 12 Months Ended
--- | --- | ---
Sep. 30, 2015 | Sep. 30, 2014 | Dec. 31, 2014 | Dec. 31, 2013
Operating expenses: |  |  |  |
Research and development | $ 6,444,000 | $ 12,652,000 | $ 12,652,000 | $ 14,157,000
General and administrative | 11,027,000 | 1,686,000 | 1,686,000 | 1,885,000
Total operating expenses | 17,471,000 |  | 14,338,000 | 16,042,000
Loss from operations | (17,471,000) | (14,338,000) | (14,338,000) | (16,042,000)
Other expense: |  |  |  |
Interest expense, net | 350,000 | 110,000 | 110,000 | 76,000
Change in fair value of derivative liability |  |  |  | 79,000
Total other expense, net | 259,000 | 110,000 | 110,000 | 155,000
Net loss | $ (17,730,000) | $ (14,448,000) | $ (14,448,000) | $ (16,197,000)
Net loss per share - basic and diluted (in dollars per share) | $ (0.94) | $ (18.26) | $ (18.26) | $ (4.06)
Weighted-average number of common shares used in net loss per share-basic and diluted (in shares) | 11,179,756 | 926,597 | 926,597 | 1,697,044
Pro Forma |  |  |  |
Other expense: |  |  |  |
Net loss per share - basic and diluted (in dollars per share) |  |  | $ (2.84) |
Weighted-average number of common shares used in net loss per share-basic and diluted (in shares) |  |  | 7,471,303 |

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