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STOCK-BASED COMPENSATION (Tables)

9 Months Ended

12 Months Ended

Sep. 30, 2015

Dec. 31, 2014

STOCK BASED COMPENSATION

Summary of stock option activity

		Shares			Weighted- average exercise price per share			Weighted- average remaining contractual term (years)			Aggregate Intrinsic Value
Outstanding at December 31, 2014			281,029		$	0.69
Granted			1,197,452			10.47
Exercised			(121,729	)		3.89
Cancelled			(506	)		2.06
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Outstanding at September 30, 2015			1,356,246		$	9.04			9.2		$	17,722
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Exercisable at September 30, 2015			208,438		$	2.65			7.9		$	4,056
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Vested and expected to vest at September 30, 2015			1,341,543		$	9.13			9.2		$	18,595
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		Number of Options			Weighted- Average Exercise Price			Weighted- Average Remaining Contractual Term (in years)			Aggregate Intrinsic Value
Outstanding at December 31, 2012			323,488		$	1.73			6.94		$	8
Granted			146,730			0.48
Exercised			(1,077	)		0.62
Cancelled			(9,559	)		2.76
Modification			(229,791	)		1.17
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Outstanding at December 31, 2013			229,791			1.17			7.02			117
Granted			89,641			0.28
Exercised			(32,390	)		2.21						—
Cancelled			(6,013	)		4.42
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Outstanding at December 31, 2014			281,029		$	0.69			7.49		$	1,505
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Vested and expected to vest at December 31, 2014			247,139		$	0.83			4.31		$	1,293
Exercisable at December 31, 2014			121,304		$	1.38			4.31		$	570

Schedule of additional information about stock option activity

		As of December 31,
		2013			2014
Weighted-average grant date fair value per share of employee option grants		$	0.28		$	0.76

Summary of restricted stock awards

		Shares			Weighted average purchase price per share
Unvested at December 31, 2014			15,387		$	0.69
Granted			194,694			5.73
Vested			(128,955	)		5.13
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Unvested at September 30, 2015(1)			81,126		$	5.73
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(1)

Excludes 72,463 shares of unvested restricted stock remaining from the early exercise of stock options as of September 30, 2015.

		Number of Shares			Weighted-Average Grant Date Fair Value
Unvested at December 31, 2012			203,342		$	0.62
Vesting of restricted stock			(89,308	)		0.55
Performance Adjustment			(58,736	)		0.62
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Unvested at December 31, 2013			55,298			0.69
Grant of restricted stock			10,869			1.24
Vesting of restricted stock			(50,780	)		0.62
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Unvested at December 31, 2014			15,387		$	0.69
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Schedule of stock-based compensation for all stock options and restricted stock awards

		Years Ended December 31,
		2013			2014
Research and development		$	24		$	12
General and administrative			38			10
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Total stock-based compensation expense		$	62		$	22
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Schedule of weighted-average assumptions used in Black-Scholes option-pricing model

		Nine months ended September 30,
		2014			2015
Risk-free interest rate			1.8	%		1.7	%
Dividend yield			—			—
Volatility			77	%		77	%
Expected term (years)			6.25			6.21

		Years Ended December 31,
		2013		2014
Risk-free interest rate		1.09% – 1.22%			1.80	%
Expected volatility		87.8%			77.1	%
Expected term (in years)		6.25			6.25
Expected dividend yield		0.0%			0.0	%

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